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Multifunctional aerogel dressing for promoting wound healing and preparation method thereof

An aerogel, multi-functional technology, applied in medical science, bandages, etc., can solve the problems of single function of wound dressings, difficult to effectively promote the healing and repair of complex wounds, etc., and achieve the effect of accelerating the healing speed and promoting cell regeneration.

Active Publication Date: 2021-01-26
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the defects in the prior art, the purpose of the present invention is to provide a multifunctional airgel wound dressing that can promote cell regeneration, prevent bacterial infection and absorb a large amount of exudate and its preparation method, so as to solve the problem of single function of the current wound dressing. , it is difficult to effectively promote the healing and repair of complex wounds

Method used

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  • Multifunctional aerogel dressing for promoting wound healing and preparation method thereof
  • Multifunctional aerogel dressing for promoting wound healing and preparation method thereof
  • Multifunctional aerogel dressing for promoting wound healing and preparation method thereof

Examples

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Effect test

Embodiment 1

[0037] Embodiment 1, the preparation of multifunctional airgel wound dressing

[0038]This embodiment relates to a multifunctional airgel dressing that promotes complex wound healing, the airgel is composed of glutamic acid derivatives, arginine-tryptophan-arginine-tryptophan-arginine - Tryptophan hexapeptide derivatives and hyaluronic acid are co-assembled through hydrogen bonding between amino acid amide bonds, and hydrogen bonding between amino acid carboxyl groups and hyaluronic acid hydroxyl groups.

[0039] Synthetic steps of glutamic acid derivatives: add L-glutamic acid methyl ester hydrochloride (2.94g, 13.9mmol) into dichloromethane (10mL) and stir, then add triethylamine (4.0mL, 29.15mmol) dropwise. Under ice bath, 1,4-phthaloyl chloride (1.30 g, 6.4 mmol) was dissolved in dichloromethane (10 mL) and added dropwise to the above solution, the ice bath was removed, the reaction was stirred at room temperature for 24 hours, and the solvent was removed by rotary evapo...

Embodiment 2

[0043] Example 2. Hyaluronic acid-based multifunctional airgel wound dressing promotes cell regeneration and wound healing

[0044] This example uses a multifunctional airgel dressing for the glutamic acid derivatives, arginine-tryptophan-arginine-tryptophan-arginine-tryptophan hexapeptide derivatives prepared in the foregoing example 1 It is co-assembled with hyaluronic acid under the hydrogen bond between the amino acid amide bond and the hydrogen bond between the amino acid carboxyl group and the hyaluronic acid hydroxyl group. Blank polystyrene culture plates were used as control materials.

[0045] Add 50 μL of the clarified solution prepared by the method in Example 1 to each well of a 96-well cell culture plate, cool to room temperature to form a hydrogel, and then dry it in a freeze dryer for 2-3 days to obtain deposited on the bottom of the 96-well plate. Multifunctional airgel dressing.

[0046] 2.1 Multifunctional airgel dressing promotes the proliferation of no...

Embodiment 3

[0058] Example 3 , Preparation of chitosan-based multifunctional airgel wound dressing

[0059] This embodiment relates to a multifunctional airgel dressing that promotes complex wound healing. The airgel is composed of phenylalanine derivatives (molecular formula see Figure 9 ), tryptophan-tryptophan-arginine-tryptophan-arginine-tryptophan hexapeptide derivatives (molecular formula see Figure 10 a) It is co-assembled with chitosan through the hydrogen bond between amino acid amide bonds, and the hydrogen bond between amino acid carboxyl and chitosan hydroxyl.

[0060] Synthetic steps of phenylalanine derivatives: L-phenylalanine methyl ester hydrochloride (3.00g, 13.9mmol) was added into dichloromethane (10mL) and stirred, then triethylamine (4.0mL, 29.15mmol) was added dropwise ). Under ice bath, dissolve 1,4-cyclohexane dichloride (1.33g, 6.4mmol) in dichloromethane (10mL) and add dropwise to the above solution, remove the ice bath, stir and react at room temperature ...

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Abstract

The invention provides a multifunctional aerogel dressing for promoting wound healing and a preparation method thereof. The preparation method of the multifunctional aerogel dressing comprises the following steps that S1, an amino acid derivative, an antibacterial polypeptide derivative and natural polysaccharide are dispersed in deionized water, and a clear solution is obtained after heating; S2,the clear solution containing the amino acid derivative, the antibacterial polypeptide derivative and the natural polysaccharide is guided into into a mold, and cooling is performed to room temperature to form hydrogel; and S3, the hydrogel is subjected to freeze drying, and the multifunctional aerogel dressing is prepared. The invention provides the multifunctional wound dressing material capable of promoting proliferation of skin fibroblasts and endothelial cells, resisting bacteria in a broad spectrum and absorbing exudate and the preparation method of the multifunctional wound dressing material. The problems that an existing wound dressing is single in function and cannot effectively promote wound healing and prevent wound infection are solved.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a multifunctional airgel dressing that promotes the healing of difficult-to-heal wounds and a preparation method thereof, in particular to a multifunctional airgel dressing that promotes the proliferation of skin fibroblasts and endothelial cells, broad-spectrum antibacterial, and absorption Exudate multifunctional wound dressing material and preparation method thereof. Background technique [0002] Due to the high incidence and prevalence of wounds (such as mechanical wounds, burns, chronic ulcer wounds, etc.) in the population, wound repair has always been one of the most important issues facing clinical medicine. quality, and even induce ulcer cancer, endangering the lives of patients. In recent years, wound repair materials have made great progress in protecting wounds, isolating bacteria, and reducing the risk of wound infection. However, the existing wound dressin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0047A61L26/0066A61L2300/214A61L2300/252A61L2300/404A61L2300/412A61L2300/45
Inventor 冯传良窦晓秋邢超
Owner SHANGHAI JIAO TONG UNIV
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