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A method for the simultaneous detection of 33 plastic additives in food contact materials

A technology for food contact materials and additives, applied in the field of analysis and detection, can solve the problems of low detection efficiency and long detection time, and achieve the effects of high detection efficiency, short detection time and high sensitivity

Active Publication Date: 2021-03-19
NANJING INST OF PROD QUALITY INSPECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the technical problems existing in existing detection methods such as the inability to simultaneously detect multiple types of plastic additives with high throughput, long detection time, and low detection efficiency, the present invention provides a liquid chromatography-tandem mass spectrometry-based method for detecting 33 types of plastic additives in food contact materials. High-Throughput Analytical Methods for Plastic Additives

Method used

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  • A method for the simultaneous detection of 33 plastic additives in food contact materials
  • A method for the simultaneous detection of 33 plastic additives in food contact materials
  • A method for the simultaneous detection of 33 plastic additives in food contact materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A series of standard solutions with a concentration of 1ng / mL~1000ng / mL were prepared for 33 kinds of plastic additive standard products with methanol as a solvent, and they were detected by liquid chromatography-tandem mass spectrometry to establish a standard curve by the external standard method.

[0035] Chromatographic conditions:

[0036] Column: C 18 (1.8µm, 2.1×50mm);

[0037] Mobile phase: A: aqueous solution (5mM ammonium acetate); B: methanol; gradient program: 0~3.0 min, 15%~60% B; 3.0~5.0 min, 60%~75% B; 5.0~6.0 min, 75% ~85 % B; 6.0~8.0 min, 85%~92% B; 8.0~10.0min, 92%~95% B; 10.0~12.0min, 95%~95% B;

[0038] Injection volume: 2 µL; flow rate: 0.35 mL / min; column temperature: 30 o c.

[0039] Mass Spectrometry Conditions: Ionization Mode: Electrospray Dual Spray Ion Source, Positive Ion Mode + Negative Ion Mode (Dual AJSESI+, ESI-); Mass Spectrometry Scanning Mode: Multiple Reaction Monitoring-MRM Mode; Nebulizer Pressure: 35 psi; Gas Temperature: 25...

Embodiment 2

[0045] Use methanol as the low-concentration standard solution of solvent preparation 33 kinds of plastic additive standard items, detect with the liquid chromatography-tandem mass spectrometry method of the present invention, determine the detection limit according to the standard that signal-to-noise ratio S / N is greater than 3, signal-to-noise ratio S / N greater than 10 determines the limit of quantitation. Chromatographic conditions: Chromatographic column: C 18 (1.8µm, 2.1×50mm) ; Mobile phase: A: aqueous solution (5mM ammonium acetate); B: methanol; gradient program: 0~3.0 min, 15%~60% B; 3.0~5.0 min, 60%~75% B; 5.0~6.0 min, 75%~85% B; 6.0~8.0 min, 85%~92%,B; 8.0~10.0 min, 92%~95% B; 10.0~12.0min, 95%~95%B ;Injection volume: 2 µL; Flow rate: 0.35 mL / min; Column temperature: 30 o c. Mass Spectrometry Conditions: Ionization Mode: Electrospray Dual Spray Ion Source, Positive Ion Mode + Negative Ion Mode (Dual AJS ESI+, ESI-); Mass Spectrometry Scanning Mode: Multiple Re...

Embodiment 3

[0049] Take a blank PE plastic film as a sample, cut it to 5mm×5mm, weigh 0.5g as a sample, accurate to 0.1mg, put it in a stoppered test tube, add standard solutions of 33 kinds of plastic additives, the concentration is 10ng / g 10mL of methanol, sealed, after infiltrating the sample components, put it into an ultrasonic cleaner, and extract it ultrasonically for 40min under the condition of 40°C±3°C. After the stoppered test tube was cooled to room temperature, the extract was completely transferred to a volumetric flask, and the stoppered test tube was washed with suitable methanol for the second time, the combined extract was concentrated to 1 mL by nitrogen purging on a nitrogen blowing instrument, and then washed with methanol. Dilute to 5.00mL, pass through a 0.22µm filter membrane, and the filtrate is detected by liquid chromatography-tandem mass spectrometry.

[0050] The detection method is:

[0051] Chromatographic conditions: Chromatographic column: C 18 (1.8µm, ...

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Abstract

The invention discloses a high-throughput analysis method for simultaneously detecting 33 kinds of plastic additives in food contact materials based on liquid chromatography-tandem mass spectrometry, and belongs to the technical field of analysis and detection. Aiming at the technical problems existing in existing detection methods such as the inability to simultaneously detect multiple types of plastic additives with high throughput, long detection time, and low detection efficiency, the method of the present invention can detect and analyze 33 kinds of plastic additives within 12 minutes, with high sensitivity , good separation, short detection time, high detection efficiency, can meet the high-throughput detection requirements of various plastic additives in food contact materials, and provide theoretical guidance and technical support for the monitoring of various types of plastic additives in food safety supervision , to protect the health and life safety of the people, and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, and in particular relates to a high-throughput analysis method for simultaneously detecting 33 kinds of plastic additives in food contact materials based on liquid chromatography-tandem mass spectrometry. Background technique [0002] In recent years, food safety issues have occurred frequently, which has aroused great concern from the society. Food safety not only refers to the safety of the food itself, but also includes the safety of food contact materials. Safety incidents caused by harmful substances in food contact materials have repeatedly hit the sensitive nerves of the public. Plastic additives refer to processing aids added in the process of plastic production and processing to improve their performance. According to different functions, they are mainly divided into antioxidants, plasticizers, ultraviolet absorbers, colorants, fillers, foaming agents, etc. Although these...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/72
CPCG01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/72G01N2030/324
Inventor 梅秀明张驰吴肖肖蒋迪尧乔玲纪晗旭杨淼徐婧婧李雨枫强雨薇
Owner NANJING INST OF PROD QUALITY INSPECTION
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