Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gastric motility promoting medicine as well as preparation method and application thereof

A technology of gastric motility and medicine, which is applied in the field of medicine, can solve the problems that diabetic patients cannot take it, it is not suitable to carry it, and the process is complicated, and achieve the effect of small weight of active ingredients, reduced daily dosage and high clinical value

Inactive Publication Date: 2020-12-15
贵州省生物技术研究开发基地有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the appetizing and digesting effect of this prescription, the three kinds of medicinal materials in the original process are all used as raw powder, and they must be made with honey. The whole process is complicated. In addition, the large honeyed pills are not easy for the elderly and children to swallow, and diabetics cannot take it. It is not suitable for carrying; if the preparation is made according to the standard of Dashanzha Pills, you need to take at least 1 pill each time, 9 grams per pill, as if you make chewable tablets with the same dose (without excipients), you need to take 18 tablets (0.5 grams per tablet) ; If it is made into chewable tablets according to the new technology, only 1 tablet (0.8 grams per tablet) is needed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gastric motility promoting medicine as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of a drug for promoting gastric motility, comprising the following steps:

[0031] (1) Add 1000g of hawthorn, 150g of Liushenqu (stir-fried bran) and 150g of fried malt in the prescription, add water and decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate into an extract with a density of 1.0g / cm -3 , the temperature is 60 ℃, cooling, the yield is 80%;

[0032] (2) Add 95% medical ethanol to make the alcohol content 50%, stir, stand still, filter, recover ethanol, concentrate the alcohol liquid into a thick paste, and the yield is 15%;

[0033] (3) Based on the chewable tablet containing 200mg of the active compound, take 200mg of the thick paste in step (2) and add 300mg of lactose, 150mg of starch slurry, 70mg of mannitol, 70mg of sorbitol, and 10mg of magnesium stearate, and prepare according to conventional techniques. Chewable tablets, 0.8g / piece, one piece each time, 1-3 times a day.

Embodiment 2

[0035] A preparation method of a drug for promoting gastric motility, comprising the following steps:

[0036] (1) Add 1000g of hawthorn, 150g of Liushenqu (stir-fried bran) and 150g of fried malt in the prescription, add water and decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate into an extract with a density of 1.0g / cm -3 , the temperature is 60 ℃, cooling, the yield is 65%;

[0037] (2) Add 95% medical ethanol to make the alcohol content to 75%, stir, stand still, filter, recover ethanol, concentrate the alcohol liquid into a thick paste, and the yield is 25%;

[0038] (3) Based on the granules containing 200mg of the active compound, take 200mg of the thick paste in step (2), add 1000mg of dextrin and 3800mg of sucrose respectively, and make granules according to conventional techniques; 5g / bag, one bag each time, 1-3 times a day.

Embodiment 3

[0040] A preparation method of a drug for promoting gastric motility, comprising the following steps:

[0041] (1) Add 1000g of hawthorn, 150g of Liushenqu (stir-fried bran) and 150g of fried malt in the prescription, add water and decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate into an extract with a density of 1.0g / cm -3 , the temperature is 60 ℃, cooling, the yield is 75%;

[0042] (2) Add 95% medical ethanol to make the alcohol content 85%, stir, stand still, filter, recover ethanol, concentrate the alcohol liquid into a thick paste, and the yield is 20%;

[0043] (3) Based on the tablet containing 200mg of the active compound, take 200mg of the thick paste in step (2) and add 250mg of starch, 25mg of dextrin, 5mg of magnesium stearate and 20mg of sodium carboxymethyl starch, and make it according to conventional techniques Tablet, 0.5g / piece, one piece each time, 1-3 times a day.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a gastric motility promoting medicine as well as a preparation method and application thereof. The method comprises the following steps that hawthorn, medicated leaven and roasted malt are added into water according to a mass ratio, decocting is conducted to obtain a decoction, filtering is conducted to obtain a filtrate, and the filtrate is concentrated to obtain a water extraction extract; the alcohol content of the extract is made to be 50 %-80 % through ethyl alcohol, stirring, standing and filtering are conducted, ethyl alcohol is recycled, and alcohol liquid is concentrated to obtain an alcohol extraction thick paste; and auxiliary materials are added into the thick paste, and uniformly mixing and drying are conducted to prepare a preparation to obtain a gastric motility promoting pharmaceutical preparation. According to the method, on the basis of the prescription of an existing big hawthorn pill, a technology is subjected to secondary development, innovation and promotion, the weight of retained effective components is reduced, the daily dosage of the medicine is reduced, the preparation of various preparations is facilitated, the compliance of patients is improved, and the quality of the variety can be integrally improved; and as a novel gastric motility promoting medicine, the medicine has high clinical value and provides medicine guarantee forrelated patients with gastropathy.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a drug for promoting gastric motility and its preparation method and application. Background technique [0002] Dashanzha Pill, pinyin name: Dashanzha Wan, comes from the 2020 edition of the Pharmacopoeia of the People's Republic of China, a Dashanzha Pill. Its prescription and preparation method are as follows: [0003] [Prescription]: Hawthorn 1000g, Liushenqu (bran fried) 150g, fried malt 150g. [0004] 【Preparation method】: Grind the above three flavors into fine powder, sieve, and mix well; take another 600g of sucrose, add 270ml of water and mix with 600g of refined honey, refine to a relative density of about 1.38 (70°C), filter, and mix with the above Mix the powder evenly and make big honeyed pills. [0005] Dashanzha Pills are composed of three flavors of traditional Chinese medicine hawthorn, Liushenqu (stir-fried bran) and fried malt, which has the effe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/8998A61K9/20A61K9/16A61K9/48A61P1/14
CPCA61K9/0056A61K9/1652A61K9/2059A61K9/4866A61K36/00A61K36/734A61K36/8998A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P1/14A61K2300/00
Inventor 杨迺嘉杜成兴霍昕杨熟英冯发进
Owner 贵州省生物技术研究开发基地有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com