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Gatifloxacin quick release tablet and preparation method thereof

A gatifloxacin and rapid technology, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of no rapid-release tablets on the market, so as to improve the dissolution rate and Bioavailability, facilitate release, improve dispersion uniformity effect

Pending Publication Date: 2020-12-15
CHENGDU HENGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Currently, gatifloxacin preparations are available in tablets and capsules, but there is no quick-release tablet on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A gatifloxacin immediate release tablet is made from the following components:

[0027] Gatifloxacin: Gatifloxacin 100mg, croscarmellose sodium 50mg, starch 20, micronized silica gel 1mg, magnesium stearate 1mg.

Embodiment 2

[0029] A preparation method of gatifloxacin quick release tablet, comprising the following steps:

[0030] a. Weigh gatifloxacin, croscarmellose sodium, starch, micronized silica gel, and magnesium stearate according to the dosage of the components:

[0031] Gatifloxacin 200mg, croscarmellose sodium 100mg, starch 150mg, micropowder silica gel 10mg, magnesium stearate 2mg;

[0032] b. Pass gatifloxacin, croscarmellose sodium, starch, micronized silica gel, and magnesium stearate through 80-120 mesh sieves;

[0033] c. Mix gatifloxacin, croscarmellose sodium and starch evenly;

[0034] d. Mix the micropowder silica gel, magnesium stearate and the mixture obtained in step c evenly, and control the mixing time should not be too long;

[0035] e. The mixture obtained in step d is compressed into tablets by powder direct compression method.

Embodiment 3

[0037] A gatifloxacin immediate release tablet is made from the following components:

[0038] Gatifloxacin 125mg, croscarmellose sodium 60mg, starch 35mg, micropowder silica gel 2mg, magnesium stearate 1mg.

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PUM

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Abstract

The invention relates to the field of medicines and processing thereof, and discloses a gatifloxacin quick release tablet and a preparation method thereof. The gatifloxacin quick release tablet is prepared from the following components in parts by weight of 100mg to 200mg of gatifloxacin, 50mg to100mg of croscarmellose sodium, 20mg to150mg of starch, 1mg to 10mg of aerosil and 1mg to 2mg of magnesium stearate. The gatifloxacin quick release tablet is prepared by taking gatifloxacin as a main medicinal component, and then adding a rapid disintegrating agent croscarmellose sodium, a multifunctional auxiliary agent starch, a flow aid aerosil and magnesium stearate. According to the tablet, a powder direct tabletting method is adopted for tabletting, and the rapid disintegrating agent croscarmellose sodium is added, so that the disintegration performance of the tablet prepared by the invention is not reduced due to early contact with water, the medicine exists in an extremely tiny particle, microcrystal or molecular state, and the disintegrating agent promotes the disintegration of the tablet through capillary action or expansion action. Therefore, aiming at the prior art, the dissolution speed and bioavailability of the medicine can be improved, and the quick-acting and efficient effects are achieved.

Description

technical field [0001] The invention relates to the field of pharmaceutical processing, and relates to a preparation method of quinolone antibiotic preparations, in particular to a gatifloxacin quick-release tablet and a preparation method thereof. Background technique [0002] The results of in vitro tests and clinical use have shown that gatifloxacin has antibacterial activity against most strains of the following microorganisms: [0003] 1. Gram-positive bacteria: Staphylococcus aureus (limited to methicillin-sensitive strains), Streptococcus pneumoniae (penicillin-sensitive strains). [0004] 2. Gram-negative bacteria: Escherichia coli, Haemophilus influenzae and parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Neisseria gonorrhoeae, Proteus mirabilis. [0005] 3. Other microorganisms: Chlamydia pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae. [0006] The preparation process of tablets mainly includes several methods such as wet granulation, dry...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K31/496A61P31/04
CPCA61K9/2054A61K9/2095A61K31/496A61P31/04
Inventor 张宇韩朋芩刘辉肖仕远
Owner CHENGDU HENGRUI PHARMA
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