Gatifloxacin quick release tablet and preparation method thereof
A gatifloxacin and rapid technology, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of no rapid-release tablets on the market, so as to improve the dissolution rate and Bioavailability, facilitate release, improve dispersion uniformity effect
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Embodiment 1
[0026] A gatifloxacin immediate release tablet is made from the following components:
[0027] Gatifloxacin: Gatifloxacin 100mg, croscarmellose sodium 50mg, starch 20, micronized silica gel 1mg, magnesium stearate 1mg.
Embodiment 2
[0029] A preparation method of gatifloxacin quick release tablet, comprising the following steps:
[0030] a. Weigh gatifloxacin, croscarmellose sodium, starch, micronized silica gel, and magnesium stearate according to the dosage of the components:
[0031] Gatifloxacin 200mg, croscarmellose sodium 100mg, starch 150mg, micropowder silica gel 10mg, magnesium stearate 2mg;
[0032] b. Pass gatifloxacin, croscarmellose sodium, starch, micronized silica gel, and magnesium stearate through 80-120 mesh sieves;
[0033] c. Mix gatifloxacin, croscarmellose sodium and starch evenly;
[0034] d. Mix the micropowder silica gel, magnesium stearate and the mixture obtained in step c evenly, and control the mixing time should not be too long;
[0035] e. The mixture obtained in step d is compressed into tablets by powder direct compression method.
Embodiment 3
[0037] A gatifloxacin immediate release tablet is made from the following components:
[0038] Gatifloxacin 125mg, croscarmellose sodium 60mg, starch 35mg, micropowder silica gel 2mg, magnesium stearate 1mg.
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