Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A wound dressing and preparation method thereof

A technology for wounds and pastes, which is applied in the field of medical supplies, can solve the problems of collagen inactivation, porous artificial skin and human body affinity reduction, etc., and achieve improved stability, fast healing, and good breathable and moisturizing properties. Effect

Active Publication Date: 2022-02-22
苏州永沁泉智能设备有限公司
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while the electrospinning of the high-temperature molten PLLA melt, the collagen solution is electrostatically sprayed, and the process can easily lead to the inactivation of the collagen due to the high-temperature environment, resulting in a significant decrease in the affinity of the prepared porous artificial skin with the human body.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A wound dressing and preparation method thereof
  • A wound dressing and preparation method thereof
  • A wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] In step (1), N,N-dimethylacetamide and water are configured into a uniform mixed solution at a volume ratio of 50:50;

[0043] Step (2), blending L-polylactic acid, polyoxyethylene 10W, and N,N-dimethylacetamide in a mass ratio of 20:12:100, stirring at 80°C and 200r / min for 6 hours; then After vacuum defoaming, use a film applicator with a knife-edge thickness of 50 microns to evenly coat it on a polyester non-woven fabric with a thickness of 30 microns and a gram weight of 50 grams per square meter; then transfer it to step (1) to obtain in the mixed solution, and keep it for 10 seconds; finally transferred to deionized water to fully wash, and dried at a temperature of 35 ° C, the first film layer was constructed on the surface of the non-woven support layer;

[0044] Step (3), blending L-polylactic acid, D-polylactic acid and N,N-dimethylacetamide at a mass ratio of 16:9:100, stirring at 90°C and 300r / min for 8 hours; then After vacuum defoaming, use a film applica...

Embodiment 2

[0049] In step (1), N-methylpyrrolidone and water are configured into a uniform mixed solution in a volume ratio of 70:50;

[0050] Step (2), blending L-polylactic acid, polyvinylpyrrolidone K60 and N-methylpyrrolidone in a mass ratio of 25:8:100, stirring at 90°C and 250r / min for 8 hours; then vacuum defoaming Finally, use a film applicator with a knife-edge thickness of 80 microns to evenly coat it on a polyester non-woven fabric with a thickness of 10 microns and a grammage of 80 grams per square meter; then transfer it to the mixed solution obtained in step (1) , and kept for 20 seconds; finally transferred to deionized water to fully wash, and dried at a temperature of 20 ° C, the first film layer was constructed on the surface of the non-woven support layer;

[0051] Step (3), blending L-polylactic acid, D-polylactic acid and N-methylpyrrolidone at a mass ratio of 18:6:100, stirring at 85°C and 300r / min for 6 hours; then vacuum defoaming Finally, use a film applicator w...

Embodiment 3

[0055] In step (1), dimethyl sulfoxide and water are configured into a uniform mixed solution at a volume ratio of 100:50;

[0056] Step (2), blending L-polylactic acid, polyethylene glycol 3K and dimethyl sulfoxide at a mass ratio of 24:18:100, stirring at 80°C and 250r / min for 8 hours; then vacuum defoaming Finally, use a film applicator with a knife-edge thickness of 20 microns to evenly coat it on a polyolefin non-woven fabric with a thickness of 50 microns and a grammage of 50 grams per square meter; then transfer it to the mixed solution obtained in step (1) , and keep it for 5 seconds; finally transferred to deionized water to fully wash, and dried at a temperature of 50 ° C, and the first film layer was constructed on the surface of the non-woven support layer;

[0057] Step (3), blending L-polylactic acid, D-polylactic acid and dimethyl sulfoxide at a mass ratio of 14:6:100, stirring at 95°C and 200r / min for 6 hours; then vacuum defoaming , use a film applicator with...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
pore sizeaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a wound dressing, comprising: a support layer; a first film layer, a second film layer and a wound dressing layer fixed on the support layer in sequence; Automatically separates from the second film layer. The invention also discloses a preparation method of the above-mentioned wound dressing. The present invention constructs the first film layer and the second film layer with large spatial structure differences on the surface of the support layer, so that the wound dressing can be automatically shed during the use of the wound dressing. The non-woven support layer, the first film layer, the second film layer and the wound dressing layer described in the technology of the present invention are all microporous structures, have good breathable and moisturizing properties, and can effectively prevent the skin around the wound from becoming dehydrated due to hypoxia. Soft, etc. lead to further deterioration of the wound, which is conducive to the rapid healing of the wound. The wound dressing prepared by the technology of the invention has good mechanical strength, ventilation and moisture retention, good biocompatibility, in vitro degradability and automatic shedding characteristics.

Description

technical field [0001] The invention relates to a wound dressing and a preparation method thereof, in particular to the structural construction and functional design of the wound dressing, and belongs to the technical field of medical supplies. Background technique [0002] The skin is the first barrier for organisms to resist the invasion of external bacteria and viruses. Especially for the human body, the skin is the largest immune organ of the human body. Human skin includes the epidermis, dermis, and subcutaneous tissue, which play multiple functions such as protecting the body, preventing the invasion of microorganisms such as bacteria and viruses, regulating the temperature of the human body, and preventing the loss of body fluids. Damage to skin tissue will not only cause damage to the subcutaneous tissue of the human body, but also seriously affect the internal balance of the human body. With the advancement of tissue engineering to prepare biomimetic materials, re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/00A61L15/26A61L15/28A61L15/32A61L15/42A61L15/44A61L15/62
CPCA61F13/00051A61F13/00063A61F13/00987A61L15/26A61L15/325A61L15/32A61L15/28A61L15/62A61L15/44A61L15/42A61L2400/04A61F13/01029A61F13/01017A61F13/01012C08L67/04C08L89/06C08L5/08
Inventor 贺永高庆林海波
Owner 苏州永沁泉智能设备有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com