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Compositions containing bioglass ceramics and their use in scar repair

A technology of biological glass and composition, which is applied in the field of medical materials, can solve the problems of weak repair function and insignificant scar repair effect, and achieve the effects of safety and reliability of the human body, inhibition of fibroblast proliferation and differentiation, and alleviation or treatment of scars

Active Publication Date: 2021-05-28
温州医科大学慈溪生物医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, rubbing preparations for external use are popular because they are convenient to use, painless, and low in cost. However, the existing rubbing preparations for external use have the disadvantages of weak repair function and insignificant scar repair effect.

Method used

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  • Compositions containing bioglass ceramics and their use in scar repair
  • Compositions containing bioglass ceramics and their use in scar repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The composition containing biological glass-ceramics of this embodiment is made of the following raw materials in parts by weight: 20 parts of biological glass with a particle size of <5 μm, 3 parts of biological glass-ceramics with a particle size of less than 5 μm, 25 parts of organic silicon elastomers, organic 38 parts of silicone oil, 0.4 parts of collagen solution, 2.3 parts of Brucea javanica oil, 2.3 parts of peach kernel oil, 1.8 parts of natural borneol, 2 parts of ethanol, 0.5 parts of menthol, 0.8 parts of titanium dioxide, 0.3 parts of vitamin A, polyethylene glycol 400 8 parts, purified water 18 parts, cetearyl alcohol 3 parts, citric acid 1 part.

[0033] Its preparation method comprises the following steps:

[0034] 1) Raw material preparation: weigh each raw material according to the formula;

[0035] 2) Mix the silicone elastomer, silicone oil, ethanol and polyethylene glycol 400, and then add bioglass, bioglass ceramics, collagen solution, javanica o...

Embodiment 2

[0038] The composition containing biological glass ceramics of this embodiment is made from the following raw materials in parts by weight: 15 parts of biological glass with a particle size of <5 μm, 10 parts of biological glass ceramics with a particle size of <5 μm, 35 parts of organic silicon elastomers, organic 35 parts of silicone oil, 0.5 parts of collagen solution, 1.8 parts of Brucea javanica oil, 3 parts of peach kernel oil, 1.2 parts of natural borneol, 3 parts of ethanol, 0.5 parts of menthol, 0.8 parts of titanium dioxide, 0.5 parts of vitamin E, polyethylene glycol 400 6 parts, 18 parts of purified water, 3 parts of glyceryl stearate, 1.2 parts of sodium lactate.

[0039] Its preparation method is with embodiment 1.

Embodiment 3

[0041] The composition containing biological glass-ceramics of this embodiment is made from the following raw materials in parts by weight: 8 parts of biological glass with a particle size of <5 μm, 8 parts of biological glass-ceramics with a particle size of less than 5 μm, 42 parts of organic silicon elastomers, organic 20 parts of silicone oil, 0.6 parts of collagen solution, 1.8 parts of Brucea javanica oil, 5 parts of peach kernel oil, 1.2 parts of natural borneol, 3.5 parts of ethanol, 0.3 parts of menthol, 1.2 parts of titanium dioxide, 0.5 parts of vitamin E, polyethylene glycol 400 4 parts, 12 parts of purified water, 4.5 parts of sorbitan olive oil, 1.2 parts of malic acid.

[0042] Its preparation method is with embodiment 1.

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PUM

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Abstract

The embodiment of the invention discloses a composition containing biological glass ceramics and its application in scar repair, belonging to the technical field of medical materials. The composition is made of the following raw materials: biological glass, biological glass ceramics, silicone elastomer, silicone oil, collagen liquid, javanica javanica oil, peach kernel oil, natural borneol, ethanol, menthol, titanium dioxide, antioxidant, Polyethylene glycol, purified water, emulsifier, acid-base stabilizer. The composition of the invention has the functions of removing putrefaction and promoting muscle growth, reducing inflammation and swelling, and repairing tissues, and can significantly inhibit the proliferation and differentiation of fibroblasts, so as to achieve the effect of alleviating or treating scars. Moreover, it is safe and reliable to the human body without any adverse reaction, and is worthy of popularization and application.

Description

technical field [0001] The embodiments of the present invention relate to the technical field of medical materials, in particular to a composition containing biological glass ceramics and its application in scar treatment and repair. Background technique [0002] Scar is the damage of physical, biological, chemical and other factors on the human skin and soft tissue, resulting in serious damage to the skin and soft tissue, which cannot be completely repaired normally by itself, and is replaced by fibrous tissue to repair the local symptoms that affect both appearance and function. The scar tissue formed after wound healing often brings long-term psychological burden and physiological obstacles to patients. [0003] At present, there are various treatments for scars, including compression of scar tissue, drug injection, and topical rubbing preparations. Among them, rubbing preparations for external use are popular because they are convenient to use, painless, and low in cost...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/02A61L31/00A61L31/14A61L31/16
CPCA61L31/005A61L31/026A61L31/028A61L31/044A61L31/06A61L31/14A61L31/16A61L2300/216A61L2300/30A61L2300/412C08L71/02C08L83/04
Inventor 张宏宇李力群孔晓霞许可
Owner 温州医科大学慈溪生物医药研究院
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