Preparation method of metal ion coordination thin-layer boron nanosheet carrier probe with targeting, drug release and detection functions
A technology of metal ions and nanosheets, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, nanotechnology for materials and surface science, etc., can solve the problem of metal ion coordination thin layer Boron nanosheet carrier probe and other issues
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Embodiment 1
[0016] The schematic diagram of the preparation method and working principle of a metal ion-coordinated thin-layer boron nanosheet carrier probe with targeting, drug release and detection functions involved in this example is as follows figure 1 As shown, the specific preparation steps are as follows:
[0017] Under magnetic stirring, add 100 mg of boron powder and double-distilled aqueous solution in which 2 mg of magnesium nitrate was dissolved in sequence to 50 mL of isopropanol, mix well, transfer to an ultrasonic cell pulverizer, use a probe for ultrasonic treatment for 5 min, and then transfer to ultrasonic cleaning Ultrasonic treatment in a water bath for 12 hours in the device, the reaction product was centrifuged at 5000rpm for 5min, the upper layer solution was centrifuged at 10000rpm for 5min, the precipitate after centrifugation was washed three times with ethanol and double distilled water, and vacuum-dried to obtain the final product. Mg@B-nanosheets;
[0018] W...
Embodiment 2
[0022] A schematic diagram of the preparation method and principle of a metal ion-coordinated thin-layer boron nanosheet carrier probe with targeting, drug release and detection functions involved in this example is shown in figure 1 As shown, the preparation of the conjugate TPP-DOX is the same as in Example 1, and other specific preparation steps are as follows:
[0023] Under magnetic stirring, add 150 mg of boron powder and double-distilled aqueous solution in which 5 mg of calcium nitrate was dissolved into 75 mL of isopropanol in sequence, mix evenly, transfer to an ultrasonic cell pulverizer, use a probe for ultrasonic treatment for 10 min, and then transfer to ultrasonic cleaning Ultrasonic treatment in a water bath for 18 hours in the device, the reaction product was centrifuged at 5000rpm for 10min, the upper layer solution was centrifuged at 10000rpm for 10min, the precipitate after centrifugation was washed three times with ethanol and double distilled water, and va...
Embodiment 3
[0027] A schematic diagram of the preparation method and principle of a metal ion-coordinated thin-layer boron nanosheet carrier probe with targeting, drug release and detection functions involved in this example is shown in figure 1 As shown, the preparation of the conjugate TPP-DOX is the same as in Example 1, and other specific preparation steps are as follows:
[0028] Under magnetic stirring, add 200mg of boron powder and double-distilled aqueous solution in which 5mg of lithium nitrate was dissolved into 100mL of isopropanol successively, mix well, transfer to an ultrasonic cell pulverizer, use a probe to sonicate for 15min, and then transfer to an ultrasonic cleaner Ultrasonic treatment in a water bath for 24 hours, the reaction product was centrifuged at 5000rpm for 15min, the upper layer solution was centrifuged at 10000rpm for 15min, the precipitate after centrifugation was washed three times with ethanol and double distilled water, and vacuum dried to obtain the fina...
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