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A kind of polymer brush with bacterial response and preparation method thereof

A technology of polymer brushes and responsiveness, which is applied in the field of polymer brushes with bacterial responsiveness and its preparation, can solve the problems that the surface antibacterial performance is difficult to effectively exert, affect the surface antibacterial performance, and the accumulation of dead bacteria, etc., to reduce bacterial adhesion The probability of attachment, the effect of excellent hemocompatibility and cytocompatibility

Active Publication Date: 2021-09-21
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in this patent, UV-induced transfer-terminated polymerization (SI-PIMP) is used to construct the double-layer antibacterial surface. The thickness of the polymer brush is only a dozen to tens of nanometers, and it is difficult to effectively exert the antibacterial performance of the surface.
In addition, the double-layer surface adopts a structure in which the upper layer is sterilizing and the lower layer is anti-adhesive, while the process of bacterial infection is to adhere first and then grow, which will easily lead to bacterial adhesion and accumulation of dead bacteria, thereby affecting the antibacterial performance of the surface

Method used

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  • A kind of polymer brush with bacterial response and preparation method thereof
  • A kind of polymer brush with bacterial response and preparation method thereof
  • A kind of polymer brush with bacterial response and preparation method thereof

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preparation example Construction

[0042] The invention provides a method for preparing a polymer brush with bacteria responsiveness, comprising:

[0043] S1) Grafting a photoinitiator on the surface of the polymer substrate to obtain a photoinitiator-modified polymer substrate;

[0044] S2) placing the photoinitiator-modified polymer substrate in a responsive monomer solution, and ultraviolet light triggers graft polymerization to obtain a responsive precursor-modified polymer substrate;

[0045] S3) placing the responsive precursor-modified polymer substrate in an anti-adhesion monomer solution, and ultraviolet light triggers graft polymerization to obtain a responsive precursor-modified polymer substrate with anti-adhesion;

[0046] S4) Place the responsive precursor and the anti-adhesion co-modified polymer substrate in a carboxyl activator solution for activation, then place it in a diamine solution for reaction, and then put it in an acid anhydride solution for reaction, to obtain Polymer substrates co-m...

Embodiment 1

[0068] Plasma pretreatment was carried out on the low-density polyethylene film, and its working parameters were: power 100W, pressure 20Pa, gas flow rate 20cc / min, temperature 25°C, time 3min; then the pretreated sample was placed in 10.0wt% 2- In the isopropylthioxanthone acetone solution, 200W high-pressure mercury lamp was irradiated for 20min, and then the sample was washed with ethanol and deionized water for 20min successively under the condition of oscillating in a water bath at 100Hz, and then the sample was placed in 5.0wt% 2-carboxylate Ethacrylate aqueous solution, 200W high-pressure mercury lamp irradiation for 6 minutes, the sample was washed as above, placed in 10.0wt% hydroxyethyl methacrylate aqueous solution, 200W high-pressure mercury lamp irradiation for 6 minutes, the sample was washed as above, placed in 2.5wt% 2-morpholineethanesulfonic acid, 6.0wt% 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 3.0wt% N-hydroxysuccinimide (the three Rat...

Embodiment 2

[0078] Plasma pretreatment was carried out on the high-density polyethylene film, and its working parameters were: power 110W, pressure 30Pa, gas flow rate 30cc / min, temperature 27°C, time 4min; then the sample was placed in acetone with 11.0wt% thioxanthone In the solution, a 210W high-pressure mercury lamp was irradiated for 21 minutes, and then the sample was washed with ethanol and deionized water for 20 minutes successively under the condition of 110 Hz water bath oscillation, and then the sample was placed in 6.0wt% acrylic acid aqueous solution, and a 210W high-pressure mercury lamp was irradiated for 7 minutes. After cleaning as above, place in 11.0wt% acryloyloxyphosphorylcholine aqueous solution, 210W high-pressure mercury lamp irradiation for 7min, after cleaning the sample as above, place in (3-(benzo[d][1,3]dioxa -5-yl)-2-iodo-5-methoxyphenyl)boronic acid (concentration 12wt%) aqueous solution, reacted for 1.1h at a reaction temperature of 5°C, and then placed the ...

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Abstract

The invention provides a preparation method of a polymer brush with bacteria responsiveness. Compared with the prior art, the present invention uses ultraviolet light to initiate active polymerization to construct a double-layer surface, so that the polymer brush has a double-layer structure with an antibacterial adhesion layer on top and an antibacterial brush layer on the bottom, which not only endows the surface with excellent blood Compatibility and cytocompatibility, but also anti-bacterial adhesion properties, effectively reducing the probability of bacterial adhesion; at the same time, the anion-cation charge reversal mechanism adopted in the present invention has high stability under physiological conditions, no The leaching of antibacterial substances can prevent bacteria from developing drug resistance. Under the condition of bacterial acidification, it has higher sensitivity than the traditional charge neutralization mechanism. It can efficiently release the loaded antibacterial agents and achieve a rapid bactericidal effect.

Description

technical field [0001] The invention belongs to the technical field of antibacterial surface construction, and in particular relates to a polymer brush with bacteria responsiveness and a preparation method thereof. Background technique [0002] During the storage, implantation or use of medical devices, bacteria may adhere to the surface of the material, thereby forming a biofilm and eventually causing bacterial infection. Bacterial infection caused by medical devices is the main cause of nosocomial infection, and nosocomial infection significantly increases the morbidity and mortality of patients, and increases the economic burden of patients. [0003] At present, there are two main ways to endow medical devices with anti-bacterial infection performance: anti-bacterial adhesion and sterilization. Loading anti-bacterial adhesion substances on the surface of the material, such as polyethylene glycol, amphoteric organic internal salts and neutral polysaccharides, etc., can ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/18C08J7/12C08L23/06C08L75/04C08L9/06
CPCC08J7/12C08J7/18C08J2309/06C08J2323/06C08J2375/04
Inventor 栾世方刘廷武闫顺杰周容涛殷敬华闫秋艳
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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