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Drug delivery system of chitosan carrier and preparation method of drug delivery system

A drug-carrying system, chitosan technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of strong side effects, toxicity, etc., to achieve strong reproducibility, production The equipment is mature and the effect of improving treatment benefits

Pending Publication Date: 2020-11-27
吴国斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cisplatin has certain toxicity when used in treatment, and it will cause strong side effects. The drug concentration in the organ when administered in the chest and abdomen is equivalent to 2.5 to 8 times that of intravenous administration.

Method used

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  • Drug delivery system of chitosan carrier and preparation method of drug delivery system
  • Drug delivery system of chitosan carrier and preparation method of drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A drug-carrying system of chitosan carrier, comprising chitosan drug carrier and loaded cisplatin;

[0029] The acetylation degree of the chitosan drug carrier is 70;

[0030] The chitosan drug carrier is preferably chitosan polyethylene glycol;

[0031] Chitosan in the chitosan polyethylene glycol: the mass ratio of polyethylene glycol is preferably 75:25;

[0032] The loaded cisplatin is preferably a cisplatin solid preparation;

[0033] The mass ratio of the loaded cisplatin: chitosan polyethylene glycol is preferably 25:75.

[0034] A preparation method of a drug-carrying system of a chitosan carrier, comprising the following steps:

[0035] (1) Weigh 15 g of chitosan, 5 g of polyethylene glycol, and 6.6 g of cisplatin; place chitosan, polyethylene glycol, and cisplatin in a sealed operating table successively into a sealed mixer and stir for 5 to 10 minutes;

[0036] (2) Put the mixed material into the hot-melt extruder through the feeding port;

[0037] (3) S...

Embodiment 2

[0041] A drug-carrying system of chitosan carrier, comprising chitosan drug carrier and loaded cisplatin;

[0042] The acetylation degree of the chitosan drug carrier is 70;

[0043] The chitosan drug carrier is preferably chitosan polyethylene glycol;

[0044] Chitosan in the chitosan polyethylene glycol: the mass ratio of polyethylene glycol is preferably 50:25;

[0045] The loaded cisplatin is preferably a cisplatin solid preparation;

[0046] The mass ratio of the loaded cisplatin: chitosan polyethylene glycol is preferably 10:50.

[0047] A preparation method of a drug-carrying system of a chitosan carrier, comprising the following steps:

[0048] (1) Weigh 10 g of chitosan, 5 g of polyethylene glycol, and 3 g of cisplatin; place chitosan, polyethylene glycol, and cisplatin in a sealed operating table successively into a sealed mixer and stir for 5 to 10 minutes;

[0049] (2) Put the mixed material into the hot-melt extruder through the feeding port;

[0050] (3) Set...

Embodiment 3

[0055] A drug-carrying system of chitosan carrier, comprising chitosan drug carrier and loaded cisplatin;

[0056] The acetylation degree of the chitosan drug carrier is 70;

[0057] The chitosan drug carrier is preferably chitosan polyethylene glycol;

[0058] Chitosan in the chitosan polyethylene glycol: the mass ratio of polyethylene glycol is preferably 75:50;

[0059] The loaded cisplatin is preferably a cisplatin solid preparation;

[0060]The mass ratio of the loaded cisplatin: chitosan polyethylene glycol is preferably 50:90.

[0061] A preparation method of a drug-carrying system of a chitosan carrier, comprising the following steps:

[0062] (1) Weigh 15 g of chitosan, 10 g of polyethylene glycol, and 13.8 g of cisplatin; place chitosan, polyethylene glycol, and cisplatin in a sealed operating table in turn into a sealed mixer and stir for 5 to 10 minutes;

[0063] (2) Put the mixed material into the hot-melt extruder through the feeding port;

[0064] (3) Set t...

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Abstract

The invention discloses a drug delivery system of a chitosan carrier and a preparation method of the drug delivery system, and particularly relates to a drug delivery system which takes chitosan as abase material, is modified by polyethylene glycol, and is mixed with a chemotherapeutic drug by adopting a melt extrusion technology and process. By applying hot melt extrusion equipment, the drug isformed through mouth mold equipment, then is cut into a cylindrical drug, and irradiated and sterilized at 60 DEG C. Compared with the traditional systemic drug delivery method disclosed by the invention, the novel drug delivery method provided by the invention has great advantages that the metabolic degradation process of the chitosan base material is utilized, and the molten drug is slowly released and controlled in vivo; particularly, systemic toxicity and adverse reaction can be effectively avoided, and the blood concentration with certain intensity is locally maintained at the source of disease; the drug use frequency and the total amount are correspondingly reduced, metabolism is discharged out of the body after the base material is degraded, and drug release is finished.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a chitosan carrier drug loading system and a preparation method thereof. Background technique [0002] Drug controlled release technology, which uses a combination of polymer substrates and released drugs to form a controlled release system to slowly release drugs to obtain the best therapeutic effect. The "trough" curve of the blood concentration of traditional pharmaceutical preparations, especially the sudden release at the beginning of the medication and the micro-release at the end, lead to unbalanced efficacy. The controlled-release preparation avoids the "peak and valley" fluctuation to a certain extent, so that the human body is in a stable and effective therapeutic blood concentration, ensuring the therapeutic effect of the drug; the drug controlled-release preparation acts on the absorption site for a long time, maintaining a strong medical strengt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/243A61K47/36A61K47/10A61P35/00
CPCA61K33/243A61K47/36A61K47/10A61P35/00
Inventor 吴国斌吴紫萱
Owner 吴国斌
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