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Flavonoid compound composition and preparation method thereof

A flavonoid compound and composition technology, which is applied in the direction of drug combination, non-active ingredients of polymer compounds, medical preparations of non-effective ingredients, etc. Problems such as no solution and low bioavailability

Active Publication Date: 2020-11-20
YUNNAN HEMPMON PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some flavonoids, such as geranyl flavone A, are insoluble in water and can only be dissolved in organic solvents such as ethanol, propylene glycol, ethyl acetate, etc., resulting in low bioavailability
Therefore, in order to achieve the effectiveness of the drug, it is necessary to administer large doses, and the use of large doses will inevitably bring compliance problems and increase the financial burden of patients; at the same time, taking large doses of drugs will also increase the burden on the liver and kidneys, resulting in unpredictable liver disease. kidney damage
In addition, in some practical experiments, geranyl flavone A has also shown certain cytotoxicity, so that this plant-derived compound has not been effectively developed and applied in the field of medicine.
[0004] At present, there are no solutions to the above problems at home and abroad.

Method used

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  • Flavonoid compound composition and preparation method thereof
  • Flavonoid compound composition and preparation method thereof
  • Flavonoid compound composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] According to parts by weight, weigh 2.5 parts of geranyl flavonoid A, 1.5 parts of pectin, 12 parts of Poloxamer 188, 2.5 parts of hydroxypropyl β-cyclodextrin, 0.5 parts of PEG4000, and 0.5 parts of potassium sorbate. 0.1 part, purified water is 80.4 parts.

[0075] Geranyl flavonoid A, poloxamer 188, hydroxypropyl beta cyclodextrin, PEG4000 and potassium sorbate are mixed and ground into a mixed powder, then pectin and purified water are added to the mixed powder, stirred and thoroughly mixed to obtain The liquid composition is recorded as Recipe 1.

Embodiment 2

[0077] According to parts by weight, 20 parts of geranyl flavonoid A, 5 parts of edible gelatin, 65 parts of Poloxamer 188, 15 parts of hydroxypropyl β-cyclodextrin, and 0.1 part of citric acid are taken. Put it in a mortar and grind it into a fine powder of 100 mesh to 200 mesh, which is recorded as prescription 2.

Embodiment 3

[0079] According to parts by weight, weigh 20 parts of geranyl flavonoid A, 5 parts of edible gelatin, 5 parts of dextran, 25 parts of medium chain fatty acid powder, 40 parts of hydroxypropyl β-cyclodextrin, and 5 parts of PEG4000 , 0.01 part of potassium sorbate and 0.2 part of vitamin C. According to the solid content of 10wt%, the above materials were dispersed in purified water, and after uniform dispersion, passed through a freeze dryer (model FD-1A-50), freeze-dried for 24 hours, and obtained 80-100 mesh fluffy fine powder, which is recorded as recipe 3.

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PUM

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Abstract

The invention discloses a flavonoid compound composition and a preparation method thereof. The flavonoid compound composition comprises a flavonoid compound, an absorption slow-release substance and asolubilizer. According to the invention, the absorption slow-release substance and the solubilizer are added into the flavonoid compound to form the composition, so that the water solubility of the flavonoid compound is improved, and the bioavailability is improved; and the cell damage is reduced at the same time, compared with single flavonoid compound administration, the cell viability is improved by at least 1.17 times, which shows that the composition can effectively reduce the cytotoxicity.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compositions, and in particular relates to a composition of flavonoids and a preparation method thereof. Background technique [0002] More than 20 kinds of flavonoids have been reported in the whole cannabis plant, the common ones are apigenin, luteolin, quercetin, orientin, rutin, vitexin, etc. In addition, geranyl flavonoid A (Cannflavin A) and geranyl flavonoid B (Cannflavin B) are two unique flavonoids in cannabis plants. Flavonoids in cannabis have been shown to have a variety of pharmacological activities. For example, Barrett et al. reported that geranyl flavonoids A / B in cannabis can greatly enhance the anti-inflammatory effect and inhibit prostaglandin E- in rheumatoid synovial cells. 2 is 30 times more inhibitory than aspirin (Barrett, M.L., A.M. Scutt, et al., "Cannflavin A and B, prenylated flavones from Cannabissativa". Experientia 42(4):(1986) 452-453); Amany K et al. repor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/60A61K47/36A61K47/42A61K47/10A61K47/38A61P29/00A61P31/00A61P31/04A61P33/02A61P25/28A61P35/00
CPCA61K31/352A61K36/60A61K47/10A61K47/36A61K47/38A61K47/42A61P25/28A61P29/00A61P31/00A61P31/04A61P33/02A61P35/00
Inventor 柳旭高伟博李惠龙赵丽梅常坦然李如彦李庆中
Owner YUNNAN HEMPMON PHARMA CO LTD
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