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Anti-infection and anti-coagulation coating for central venous catheter and preparation method of anti-infection and anti-coagulation coating

A central venous catheter, anti-infection technology, applied in anti-coagulation treatment, catheter, coating and other directions, can solve the problems of poor antibacterial effect, cumbersome process operation steps, poor anti-infection effect, etc., and achieves improved smoothness and simple process. , easy to obtain the effect of

Inactive Publication Date: 2020-11-03
SHANDONG ZHUSHI PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the above-mentioned technical problems, the present invention provides an anti-infection and anti-coagulation coating for central venous catheters and a preparation method thereof, to solve the problems of the existing anti-infection and anti-coagulation coatings for central venous catheters and its preparation methods. Poor anti-infection effect, cumbersome process steps and poor antibacterial effect

Method used

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  • Anti-infection and anti-coagulation coating for central venous catheter and preparation method of anti-infection and anti-coagulation coating
  • Anti-infection and anti-coagulation coating for central venous catheter and preparation method of anti-infection and anti-coagulation coating
  • Anti-infection and anti-coagulation coating for central venous catheter and preparation method of anti-infection and anti-coagulation coating

Examples

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Effect test

Embodiment

[0042] as attached figure 1 shown

[0043] An anti-infection and anti-coagulant coating for a central venous catheter comprises the following raw materials in parts by weight: 0.1-1% polyvinylpyrrolidone, 0.2-2% minocycline hydrochloride, 0.7-1% KH560 silane coupling agent, poly Vitamin iodine 2-3%, medical disinfectant 90-93%.

[0044] Preferably, the povidone-iodine is a complex product composed of polyvinylpyrrolidone and iodine.

[0045] A preparation method for an anti-infection anti-coagulation coating for a central venous catheter comprises the following steps:

[0046] S101: Central venous catheter antibacterial sterilization and elimination process, take out the central venous catheter, rinse it with medical disinfectant water, dry it in the air, and then sterilize it in an antibacterial sterilization box, and heat it by heating to remove the central venous catheter The excess residual liquid on the surface of the venous catheter is stored in a stainless steel box ...

specific Embodiment 1

[0070] An anti-infection and anti-coagulation coating for a central venous catheter comprises the following raw materials in parts by weight: 0.1% polyvinylpyrrolidone, 0.2% minocycline hydrochloride, 0.7% KH560 silane coupling agent, 2% povidone-iodine, 90% medical disinfectant.

[0071] A preparation method for an anti-infection anti-coagulation coating for a central venous catheter comprises the following steps:

[0072] Step 1: Central venous catheter antibacterial sterilization and elimination process, take out the central venous catheter, rinse it with medical disinfectant water, dry it in the air, and then perform sterilization and sterilization work through an antibacterial sterilization box, and heat it by heating to remove The excess residual fluid on the surface of the central venous catheter is stored in a stainless steel box at normal temperature and pressure, for use;

[0073] Step 2: Preparation of povidone-iodine liquid layer, the specific operation should be ...

specific Embodiment 2

[0086] An anti-infection and anti-coagulation coating for a central venous catheter comprises the following raw materials in parts by weight: 1% polyvinylpyrrolidone, 2% minocycline hydrochloride, 1% KH560 silane coupling agent, 3% povidone-iodine, 93% medical disinfectant.

[0087] A preparation method for an anti-infection anti-coagulation coating for a central venous catheter comprises the following steps:

[0088] Step 1: Central venous catheter antibacterial sterilization and elimination process, take out the central venous catheter, rinse it with medical disinfectant water, dry it in the air, and then perform sterilization and sterilization work through an antibacterial sterilization box, and heat it by heating to remove The excess residual fluid on the surface of the central venous catheter is stored in a stainless steel box at normal temperature and pressure, for use;

[0089] Step 2: Preparation of povidone-iodine liquid layer, the specific operation should be carrie...

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Abstract

The invention provides an anti-infection and anti-coagulation coating for a central venous catheter. The anti-infection and anti-coagulation coating comprises the following raw materials in parts by weight: 0.1-1% of polyvinylpyrrolidone, 0.2-2% of minocycline hydrochloride, 0.7-1% of a KH560 silane coupling agent, 2-3% of povidone iodine and 90-93% of medical disinfectant fluid. The preparation method of the anti-infection and anti-coagulation coating for the central venous catheter comprises the following steps: a central venous catheter antibacterial sterilization elimination procedure, povidone iodine liquid layer preparation work, anti-infection and anti-coagulation blood layer preparation work, anti-infection and anti-coagulation central venous catheter preparation and finished product obtaining. The anti-infection and anti-coagulation coating is cured to the surface of the central venous catheter at high temperature, dip-coating processing is conducted in a multiple dip-coatingmode, the smoothness of the central venous catheter can be improved, the friction coefficient of the central venous catheter is reduced, and convenience of medical use and operation is guaranteed; andthe process is simple, the used raw materials are easy to obtain, the medical effect is obvious, the antibacterial and anti-infection rate is high, medical accidents can be reduced, and the medical operation safety is guaranteed.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an anti-infection and anti-coagulation coating for a central venous catheter and a preparation method thereof. Background technique [0002] The most widely used anti-infection central venous catheters in the world are the Arrow series products developed and produced by the American Teleflex Company, which use the swelling properties of the polyurethane material on the surface of the catheter to absorb antibacterial substances widely used in clinical practice to achieve the antibacterial performance of the catheter itself, but there is no Anticoagulant effect, the Vantex series of anticoagulant and anti-infection central venous catheters produced by American Edwards uses polyurethane-based OLIGON polymers (including: silver, platinum, and black carbon), and the surface is also attached with AMC thrombosis protective layer , the product uses silver-platinum car...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/16A61L33/06A61L33/00
CPCA61L29/08A61L29/085A61L29/16A61L33/0041A61L33/0082A61L33/062A61L2300/202A61L2300/216A61L2300/406A61L2300/42A61L2300/606A61L2420/02A61L2420/06C08L39/06
Inventor 朱坤福刘文广韩东
Owner SHANDONG ZHUSHI PHARMA GRP CO LTD
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