Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antibacterial active dressing and preparation method thereof

A technology of antibacterial activity and microspheres, which is applied in the field of antibacterial active dressings and its preparation, can solve the problems of cell irritation and poor water solubility, etc., and achieve improved performance of easy degradation, reduced dosage, good mechanical properties and biocompatibility Effect

Inactive Publication Date: 2020-09-22
GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water solubility of chitosan is poor, and hydrochloric acid or acetic acid should be added to increase the solubility when dissolving. These acids are difficult to completely remove during cleaning and are irritating to cells.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antibacterial active dressing and preparation method thereof
  • Antibacterial active dressing and preparation method thereof
  • Antibacterial active dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]A kind of carboxymethylcellulose / sericin dressing (CMC / Ser), its preparation method is: sodium carboxymethylcellulose powder (2g) and sericin (0.2g) are added into 100mL deionized water gradually, then Stir gently until completely dissolved, add 0.1 g 5 wt.% citric acid (polymer weight) as a crosslinking agent and 0.06 g 3 wt.% glycerol (polymer weight) as a crosslinking extender, and then pour the mixture into poly Then, the mold was stored at -70°C overnight and freeze-dried; then, the sample was cross-linked at 70°C for 72 hours to obtain a carboxymethylcellulose / sericin dressing (CMC / Ser).

[0038] Among them, the preparation method of sericin protein is as follows: heat and alkali degumming method is used to extract sericin from silkworm cocoons, 5.0g silkworm cocoons are cut into pieces and washed with deionized water, immersed in 200mL 0.02M Na 2 CO 3 The solution was boiled for 1 hour, then the insoluble residue was removed by centrifugation (3500rpm, 10 minutes...

Embodiment 2

[0040] A kind of carboxymethylcellulose / sericin dressing (CMC / Ser), its preparation method is: add carboxymethylcellulose sodium powder (2g) and sericin (1g) gradually to 100mL deionized water, then gently Gently stir until completely dissolved, add 0.1g 5wt.% citric acid (polymer weight) as a crosslinking agent and 0.06g 3wt.% glycerin (polymer weight) as a crosslinking extender, and then pour the mixture into polytetrafluoroethylene Then, the mold was stored at -70°C overnight and freeze-dried; then, the sample was cross-linked at 70°C for 72 hours to obtain a carboxymethylcellulose / sericin dressing (CMC / Ser).

[0041] The preparation method of sericin is the same as that in Example 1.

Embodiment 3

[0043] A kind of carboxymethylcellulose / sericin dressing (CMC / Ser), its preparation method is: add carboxymethylcellulose sodium powder (2g) and sericin (2g) into 100mL deionized water gradually, then gently Gently stir until completely dissolved, add 0.1g 5wt.% citric acid (polymer weight) as a crosslinking agent and 0.06g 3wt.% glycerin (polymer weight) as a crosslinking extender, and then pour the mixture into polytetrafluoroethylene Then, the mold was stored at -70°C overnight and freeze-dried; then, the sample was cross-linked at 70°C for 72 hours to obtain a carboxymethylcellulose / sericin dressing (CMC / Ser).

[0044] The preparation method of sericin is the same as that in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
tensile strengthaaaaaaaaaa
water absorptionaaaaaaaaaa
Login to View More

Abstract

The invention relates to an antibacterial active dressing. The dressing is prepared from the following components in percentage by mass: 1%-4% of sodium carboxymethyl cellulose, 0.2%-2% of sericin, 0.01%-0.2% of clindamycin-containing carboxymethyl cellulose microspheres and the balance of deionized water. Clindamycin is loaded on carboxymethyl cellulose microspheres (CMs) to obtain the carboxymethyl cellulose microspheres (CMs@CLDM) with the uniform particle size so as to develop synergistically effective antibacterial microspheres, so that the addition amount of antibiotics is reduced underthe condition of not reducing the antibacterial property, and meanwhile the biocompatibility of materials is improved; and based on a sericin / carboxymethyl cellulose dressing, the easy-to-degrade performance of a pure carboxymethyl cellulose (CMC) dressing can be improved, and the water stability and cell adhesion performance of the CMC dressing are improved by adding the sericin.

Description

technical field [0001] The invention relates to an antibacterial active dressing and a preparation method thereof, belonging to the technical field of medical biological materials. Background technique [0002] The skin plays a key role in protecting the body from foreign invaders. The skin, as the first and largest layer in contact with the surrounding environment, is more prone to injury. Therefore, the use of effective wound dressings has been recognized as an effective way to speed up the healing process. A suitable wound dressing should be able to provide optimal conditions around the wound, which best mimics the extracellular matrix (ECM) of the skin to help allow epithelial cell motility, proper oxygen delivery, a moist environment, drainage of wound exudates, And prevent wound infection to a great extent. [0003] In this regard, sodium carboxymethylcellulose (CMC)-based dressings have received particular attention due to their richness, transparency, and low cost...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/32A61L15/28A61L15/44A61L15/46
CPCA61L15/28A61L15/32A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/232A61L2300/406A61L2300/602A61L2300/622C08L1/286
Inventor 蓝咏刘玉何灼华冯龙宝
Owner GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com