Soft capsule shell and preparation method thereof
A technology of soft capsules and gelatin capsules, which is applied in the fields of capsule transportation, pharmaceutical formulations, and medical preparations of non-effective ingredients, etc., and can solve problems such as the large impact of soft capsule disintegration, the denaturation of the soft capsule shell, and the impact on the activity of traditional Chinese medicine. Achieve the effects of improving bioavailability, slow growth, and improving stability
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Embodiment 1
[0034] Rubber prescription: 100 parts of gelatin, 40 parts of glycerin, and 130 parts of water. Mix the above materials evenly, emulsify in a glue tank at 80°C for 2 hours, degas to remove air bubbles, and transport the gelatin solution through the filter screen to the rubber box of the main machine through a pressure device to make a rubber with uniform thickness.
[0035] Coating liquid prescription: 4 parts of hydroxypropyl methylcellulose HPMC, 2 parts of glycerin, 400 parts of water. Mix the above materials evenly, and stir at 70°C for 30 minutes, take it out, keep stirring and cool to room temperature to obtain the coating solution.
[0036] Use the salivation method to evenly spread the cooled coating solution on the surface of the rubber, and perform the first drying until the water content of the rubber is 25%-30%, and the coating surface of the rubber faces the content, and use a soft capsule pellet machine The coated rubber-wrapped content is compressed into a soft...
Embodiment 2
[0038] Rubber prescription: 100 parts of gelatin, 40 parts of glycerin, and 130 parts of water. Mix the above materials evenly, emulsify in a glue tank at 80°C for 2 hours, degas to remove air bubbles, and transport the gelatin solution through the filter screen to the rubber box of the main machine through a pressure device to make a rubber with uniform thickness.
[0039] Coating solution prescription: 6 parts of hydroxypropyl methylcellulose HPMC, 3 parts of glycerin, and 400 parts of water. Mix the above materials evenly, and stir at 70°C for 30 minutes, take it out, keep stirring and cool to room temperature to obtain the coating solution.
[0040] Use the salivation method to evenly spread the cooled coating solution on the surface of the rubber, and perform the first drying until the water content of the rubber is 25%-30%, and the coating surface of the rubber faces the content, and use a soft capsule pellet machine The coated rubber-wrapped content is compressed into ...
Embodiment 3
[0042]Rubber prescription: 100 parts of gelatin, 40 parts of glycerin, and 130 parts of water. Mix the above materials evenly, emulsify in a glue tank at 80°C for 2 hours, degas to remove air bubbles, and transport the gelatin solution through the filter screen to the rubber box of the main machine through a pressure device to make a rubber with uniform thickness.
[0043] Coating solution prescription: 8 parts of hydroxypropyl methylcellulose HPMC, 4 parts of glycerin, and 400 parts of water. Mix the above materials evenly, and stir at 70°C for 30 minutes, take it out, keep stirring and cool to room temperature to obtain the coating solution.
[0044] Use the salivation method to evenly spread the cooled coating solution on the surface of the rubber, and perform the first drying until the water content of the rubber is 25%-30%, and the coating surface of the rubber faces the content, and use a soft capsule pellet machine The coated rubber-wrapped content is compressed into a...
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