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Antimicrobial agent containing hypochlorous acid

An antimicrobial and microorganism technology, applied in the directions of biocides, biocides, antifungals, etc., can solve problems such as danger and chlorine generation, and achieve excellent bactericidal effect and safety effect

Inactive Publication Date: 2020-09-04
FREEKIRA PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The aqueous solution of sodium hypochlorite alone (excluding water and components other than sodium hypochlorite) is relatively stable in the alkaline area, but it will decompose very violently in the acidic area and produce chlorine gas, so it is dangerous

Method used

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  • Antimicrobial agent containing hypochlorous acid
  • Antimicrobial agent containing hypochlorous acid
  • Antimicrobial agent containing hypochlorous acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (Aqueous solution of hypochlorous acid and its production example)

[0051] Weigh sodium hypochlorite according to 0.026% (W / V), mix with purified water for dilution. Diluted hydrochloric acid (approximately 9.5 to 10.5% (W / V)) was added to the sodium hypochlorite aqueous solution prepared by this dilution, and pH was adjusted to 6.0 to 6.5. The residual chlorine concentration in this solution was 220 ppm.

[0052] (Component analysis of hypochlorous acid aqueous solution)

[0053] The component analysis table of the hypochlorous acid aqueous solution is shown below.

[0054] [Table 1]

[0055]

[0056]

[0057] In addition, pure water having the following properties was used in this example.

[0058] [Table 2]

[0059] project properties and characteristics character Colorless, transparent, odorless liquid purity Organic carbon content≤0.50mg / L Conductivity Conductivity (25℃)≤2.1μS / cm

[0060] *Conductivity test: Measure...

Embodiment 2

[0062] (Measurement of antiviral effect on norovirus)

[0063] (1) Test strain

[0064] Norovirus (Norovirus belonging to NV gene group 2) from feces was used. The virus was qualitatively confirmed according to the norovirus detection method (PCR method) recommended by the Japanese Ministry of Health, Labor and Welfare.

[0065] (2) Preparation of the sample to be tested

[0066] The hypochlorous acid aqueous solution was adjusted so that the residual chlorine concentration was 200 ppm, and it was used as a test sample. The following samples were prepared using the above-mentioned test samples for the measurement of the antiviral effect.

[0067] (a) Negative control (500 μL of norovirus suspension)

[0068] (b) Positive control (5-fold dilution: 100 μL of norovirus suspension + 400 μL of purified water)

[0069] (c) Sample (100 μL of norovirus suspension + 400 μL of the tested sample)

[0070] (3) Measurement method

[0071] The proliferation of norovirus was confirmed...

Embodiment 3

[0077] (Determination of the bactericidal effect on bacteria)

[0078] (1) For test sample

[0079] The aqueous hypochlorous acid solution prepared in Example 1 was used. The residual chlorine concentration of the stock solution was 200 ppm. This stock solution was serially diluted 2-fold and diluted to 100 ppm, 50 ppm, 25 ppm, 12.5 ppm and 6.3 ppm for use.

[0080] (2) Test method

[0081] 1) Test bacteria

[0082] Seven kinds of bacteria shown in Table 4 below were used. The stock solution with a residual chlorine concentration of 200ppm was serially diluted 2-fold with sterilized distilled water to prepare dilutions of 100ppm, 50ppm, 25ppm, 12.5ppm, and 6.3ppm, and dispensed 5mL each into a 20mL test tube for use. The concentration of residual chlorine in the sample was measured using a hand-held water quality detector AQ-101 (manufactured by Shibata Scientific Co., Ltd.).

[0083] [Table 4] The type of bacteria to be tested and the minimum bactericidal concentration ...

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Abstract

The purpose of the present invention is to provide a hypochlorous acid aqueous solution having excellent antimicrobial effect and safety. An antimicrobial agent is provided which is a hypochlorous acid aqueous solution with a pH of 3.0-6.7, wherein the effective chlorine concentration in the aqueous solution is 50-260 ppm. Further, a sterilization method is provided characterized by immersing themember to undergo sterilization treatment in the aforementioned antimicrobial agent for 0.5-10 minutes. The antimicrobial agent has a broad antimicrobial spectrum of noroviruses, Staphylococcus aureusand other bacteria, yeast belonging to Rhodotorula, and Cladosporium cladosporioides and other fungi.

Description

technical field [0001] The present invention relates to an antimicrobial agent which has an excellent bactericidal effect and safety and uses an aqueous solution of hypochlorous acid as an active ingredient. Background technique [0002] In recent years, the popularization of small medical devices capable of resecting affected areas with low invasiveness, represented by endoscopes, has been promoted. Compared with highly invasive surgical procedures such as thoracotomy / laparotomy, treatment using such small medical equipment has the advantages of less burden on patients and shorter hospital admission period. On the other hand, when these medical devices are used in one treatment, they are heavily contaminated by adhesion of blood, bacteria, etc., and therefore there is a possibility that infection may spread if they are not sufficiently sterilized. [0003] Sterilization of such medical devices requires high levels of antimicrobial agents, currently using modified forms of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/00A01P1/00A01P3/00A61K33/20A61P31/00A61P31/02A61P31/04A61P31/10A61P31/12A01N59/08
CPCA01N59/00A61K33/20A61P31/00A61P31/02A61P31/04A61P31/10A61P31/12A23L3/358A61L2101/06A61L2/18A61L2202/24
Inventor 池本庆且
Owner FREEKIRA PHARM INC
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