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Hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction and synthesis method thereof

A polystyrene resin, streptomycin sulfate technology, applied in chemical instruments and methods, other chemical processes, preparation of sugar derivatives, etc., can solve problems such as toxic side effects, hearing loss in patients, and restrictions on the application of streptomycin, etc. Achieve stable quality, excellent performance and high cost performance

Pending Publication Date: 2020-08-14
SHAANXI LANSHEN SPECIAL RESIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because the fermentation broth often contains some structurally similar impurities, such as streptavidin, bis-streptavidin and impurity No. 1, etc., this brings difficulties to the separation and purification of streptomycin, so that commercial streptomycin also contains Certain impurities can produce some toxic and side effects, especially easy to cause hearing loss in patients, which limits the application of streptomycin

Method used

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  • Hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction and synthesis method thereof
  • Hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction and synthesis method thereof
  • Hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction and synthesis method thereof

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preparation example Construction

[0028] The invention provides a kind of synthetic method of hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction, comprising the following steps:

[0029] S1, synthetic polystyrene resin macroporous white ball;

[0030] Water phase: Dissolve carboxymethyl cellulose, gelatin, and methylene blue in water at room temperature as the water phase;

[0031] Oil phase: The polymerized monomers are styrene and divinylbenzene, of which divinylbenzene accounts for 6% to 8% by mass, and the rest is styrene. After mixing the monomer and porogen, it becomes the oil phase. The porogen For 200# gasoline and white oil.

[0032] The mass ratio of 200# gasoline to white oil (1~3):5, and the mass ratio of porogen to monomer (0.5~1.0):1.

[0033] In the reactor with the water phase, heat the water phase to 55°C, add the oil phase to the reactor, the volume ratio of the water phase and the oil phase is (2-4):1, and disperse the oil phase into the water by stirring In the...

Embodiment 1

[0043] Hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction and synthesis method

[0044] (1) Synthetic polystyrene resin macroporous white ball

[0045] Water phase: Dissolve carboxymethyl cellulose, gelatin, and methylene blue in water at room temperature as the water phase;

[0046] Oil phase: Polymerized monomers are styrene and divinylbenzene, of which divinylbenzene accounts for 7%, and the rest is styrene. After mixing the monomer and porogen, it becomes the oil phase, and the porogen is 200# gasoline And white oil, the mass ratio of 200# gasoline to white oil is 1:5, and the mass ratio of porogen to monomer is 0.5:1.

[0047] In the reactor with the water phase, heat the water phase to 55°C, add the oil phase to the reactor, the volume ratio of the water phase and the oil phase is 3.5:1, disperse the oil phase into the water phase by stirring, and control The particle size is 0.3-0.8mm, heat up to 70-80°C, react for 3 hours, continue to heat ...

Embodiment 2

[0055] Hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction and synthesis method

[0056] The degree of crosslinking of the synthetic polystyrene resin macroporous white spheres was adjusted to 8%, and other processes were as in Example 1.

[0057] The detection performance indicators are as follows

[0058]

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Abstract

The invention discloses hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction and a synthesis method of the hydrophilic polystyrene macroporous resin. The synthesis method comprises the following steps: synthesizing polystyrene resin macroporous white balls; adding the prepared polystyrene resin macroporous white balls into a reaction kettle, adding hydroxyimine into the reaction kettle, adding dichloroethane for swelling, adding acetic anhydride, heating, carrying out heat preservation treatment, cooling, adding industrial sulfuric acid, heating, carrying out heat preservation, cooling again, filtering out mother liquor, boiling the balls, and washing the balls to obtain polystyrene resin macroporous amide balls; adding liquid caustic soda with the concentration of30wt% into the prepared polystyrene resin macroporous amide balls, heating, controlling the pressure of the reaction kettle, carrying out hydrolysis after heat preservation treatment, cooling after heat preservation is finished, filtering out mother liquor, and washing with water to obtain the polystyrene hydrophilic macroporous resin for streptomycin sulfate extraction. The prepared resin is excellent in performance and high in cost performance, streptomycin sulfate in streptomycin sulfate fermentation liquor can be purified and effectively separated, and it is guaranteed that the quality ofa purified product is stable.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis of polymer separation materials, and in particular relates to a hydrophilic polystyrene macroporous resin for streptomycin sulfate extraction and a synthesis method thereof. Background technique [0002] Streptomycin sulfate is an aminoglycoside antibiotic drug, which has a strong antibacterial effect on Mycobacterium tuberculosis, and is effective against most Gram-positive bacteria (such as various streptococci) and bacilli (such as Pseudomonas aeruginosa, anaerobic bacteria ) antibacterial effect is not strong; it also has antibacterial effect on many Gram-negative bacteria (G-) such as Escherichia coli, Klebsiella pneumoniae, Enterobacter, Salmonella, Brucella, etc. Tuberculosis has a remarkable curative effect and is a first-choice drug for the treatment of pulmonary tuberculosis. It has the effect of inhibiting the reproduction of Mycobacterium tuberculosis and the production of to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/36C08J9/28C08F212/08C08F212/36B01J20/26B01J20/30B01D15/08C07H15/238C07H1/06C08L25/08
CPCC08J9/36C08J9/28C08F212/08B01J20/261B01D15/08C07H15/238C07H1/06C08J2325/08
Inventor 刘红院杨江张运张红攀潘群艳李小侠
Owner SHAANXI LANSHEN SPECIAL RESIN
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