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Tamarind gum plant enteric empty capsule and preparation method thereof

A technology of tamarind gum and hollow capsules is applied in the directions of capsule delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc. The effect of improving the property and enteric coating, avoiding the loss of water, and improving the stable performance

Inactive Publication Date: 2020-07-31
HUBEI HUMANWELL PHARMACEUTICAL EXCIPIENTS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional gelatin capsules use medicinal gelatin as the main raw material, which has problems such as easy softness when heated, brittleness when cold, and gelation reaction with drugs. In addition, the impact of animal diseases such as "mad cow disease" in recent years, religious beliefs, etc. Restrictions, and Shifts in Consumer Preferences, Vegetable Capsules Are Increasingly Popular in the Market
[0003] Plant enteric-coated hollow capsules are an important variety of plant capsules. In practical applications, especially after long-term storage, the stability of the hollow capsules becomes weaker, and moisture migration occurs between the hollow capsules, air and drugs, resulting in brittle, Problems such as powder leakage affect the product quality of capsules

Method used

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  • Tamarind gum plant enteric empty capsule and preparation method thereof
  • Tamarind gum plant enteric empty capsule and preparation method thereof
  • Tamarind gum plant enteric empty capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 496g of water, heat it to 45°C with the first three-necked flask, weigh 5g of tamarind gum, add it to the first three-necked flask, and keep stirring for 30min to obtain a gel solution;

[0028] Take 496g of water, keep it warm at 30°C in the water bath of the second three-necked flask, weigh 1g of sodium dodecyl sulfate and 1g of calcium stearoyl lactylate, add them into the second three-necked flask, keep stirring for 10min, and obtain the modified solution;

[0029] Slowly introduce the modified solution in the second three-necked flask into the first three-necked flask, keep the system temperature in the first three-necked flask at 45°C, keep stirring for 5 minutes, and after the stirring is completed, weigh 1g of carrageenan and add it to the first three-necked flask In a three-neck flask, keep warm and stir for 30 minutes, mix evenly, keep warm for 2 hours, and get the glue;

[0030] The glue is used in the capsule production line, the mold is dipped in the g...

Embodiment 2

[0032] Take 448g of water, heat it to 65°C with the first three-necked flask, weigh 50g of tamarind gum, add it to the first three-necked flask, and keep stirring for 60min to obtain a gel solution;

[0033] Take 448g of water, keep the second three-necked flask at 45°C in a water bath, weigh 5g of Tween-80 and 5g of sodium dioctyl sulfosuccinate, 10g of calcium stearoyl lactylate, 5g of calcium chloride and 5g of calcium lactate, and add In the second three-necked flask, insulated and stirred for 30min to obtain a modified solution;

[0034] Slowly introduce the modified solution in the second three-necked flask into the first three-necked flask, keep the system temperature in the first three-necked flask at 65°C, keep the temperature and stir for 10min, and after the stirring is completed, weigh 3g iron oxide red and 10g knot Add cold glue and 10g of konjac gum to the first three-necked flask, heat and stir for 60 minutes, mix evenly, keep heat and stand for 4 hours, and obt...

Embodiment 3

[0038] Take 472g of water, heat it to 55°C with the first three-necked flask, weigh 30g of tamarind gum, add it to the first three-necked flask, and keep stirring for 40min to obtain a gel solution;

[0039] Take 473g of water, keep it warm at 35°C in a second three-necked flask with a water bath, weigh 6g of polyvinyl alcohol, 4g of calcium stearoyl lactylate and 5g of calcium gluconate, add them to the second three-necked flask, keep it warm and stir for 20min to obtain a modified solution ;

[0040] Slowly introduce the modified solution in the second three-necked flask into the first three-necked flask, keep the system temperature in the first three-necked flask at 50°C, heat and stir for 6 minutes, after the stirring is completed, weigh 1g of indigo and 10g of guar beans Glue was added into the first three-necked flask, kept stirring for 40 minutes, mixed evenly, left standing for 3 hours while kept warm, to obtain the glue solution;

[0041] The glue is used in the caps...

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Abstract

The invention provides a tamarind gum plant enteric empty capsule and a preparation method thereof. The enteric empty capsule mainly comprises tamarind gum, an enteric pore-foaming agent, a gel, a surfactant, calcium stearoyl lactylate and a coloring agent, and the enteric empty capsule is obtained by preparing a glue solution, dipping the glue solution into a mold by using a capsule mold, and carrying out drying, demolding, cutting and nesting. Compared with a conventional enteric empty capsule, the capsule provided by the invention has better stability and still has good stable data after being stored for a long time, and the used raw materials are plant raw materials, so that the capsule is more green and environment-friendly and meets social requirements.

Description

technical field [0001] The invention relates to the technical field of medical auxiliary materials, in particular to a tamarind gum vegetable enteric-coated hollow capsule and a preparation method thereof. Background technique [0002] Traditional gelatin capsules use medicinal gelatin as the main raw material, which has problems such as easy softness when heated, brittleness when cold, and gelation reaction with drugs. In addition, the impact of animal diseases such as "mad cow disease" in recent years, religious beliefs, etc. Due to restrictions, and shifting consumer preferences, vegetable capsules are gaining popularity in the market. [0003] Plant enteric-coated hollow capsules are an important variety of plant capsules. In practical applications, especially after long-term storage, the stability of the hollow capsules becomes weaker, and moisture migration occurs between the hollow capsules, air and drugs, resulting in brittle, Problems such as powder leakage affect ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/12A61K47/20A61K47/02
CPCA61K9/4816A61K9/4891A61K47/02A61K47/12A61K47/20A61K47/36
Inventor 黄建华任海民周峰黄猛陈明朝王耀龙
Owner HUBEI HUMANWELL PHARMACEUTICAL EXCIPIENTS CO LTD
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