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Composite neural electrode and preparation method thereof

A nerve and electrode technology, applied in the fields of neuroscience and biomedical instrument engineering, can solve the problems of increasing difficulty in brain tissue damage, difficult to achieve high positioning, etc., and achieve the effect of good mechanical stability

Active Publication Date: 2020-07-28
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This greatly increases the difficulty of experimental operations and damage to brain tissue, and it is difficult to achieve a high degree of positioning for drug injection and electrode implantation

Method used

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  • Composite neural electrode and preparation method thereof
  • Composite neural electrode and preparation method thereof
  • Composite neural electrode and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] The invention provides a flexible nerve electrode / adeno-associated virus (rAAV) / PEG multifunctional composite nerve electrode, which is prepared by a secondary co-assembly curing method. The specific method is as follows:

[0083] 1. Prepare the implantable flexible nerve electrode: select the implantable flexible nerve electrode with comb structure as described in CN106667475A as the processing object, and its processing process is as follows: figure 1 As shown, i is a silicon dioxide / silicon substrate, and ii~v parts represent (ii) magnetron sputtering aluminum sacrificial layer on the surface of silicon dioxide / silicon substrate, (iii) spin-coating bottom polyimide insulating layer, (iv) thermally evaporated gold layer and (v) spin-coated second polyimide insulating layer. Taking part i as an example, the upper figure shows the front view of the electrode, and the lower figure shows the cross-sectional view shown by the dotted line in the figure; part vi shows the e...

Embodiment 2

[0095] In this example, the composite nerve electrode prepared in Example 1 was used to implant the mouse brain to verify the feasibility of rAAV virus loading on the flexible nerve electrode. The specific operation is as follows:

[0096] 1. Electrode implantation: take a healthy C57 mouse, inject pentobarbital sodium according to the standard of 0.01g / mL to anesthetize the mouse; after the mouse is deeply anesthetized, fix it on a stereotaxic instrument, dip a cotton swab in iodine Apply disinfection on the head of the mouse, and cut off the hair; use scissors to cut off the mouse scalp along the middle seam, clean up the surface tissue of the skull, and expose the clean skull.

[0097] Fix the iron sheet with the window on the mouse skull with tissue glue to fix the electrode and connect the ground wire; use a cranial drill above the target brain region M2 / VO (coordinates, +2.50mm, +0.80mm) Drill a 1mm×1mm square hole and carefully pick off the dura mater for implanting ele...

Embodiment 3

[0102] This embodiment provides a flexible nerve electrode / adeno-associated virus / optical fiber / PEG multifunctional composite nerve electrode. The specific preparation method is as follows:

[0103] 1. Preparation of flexible nerve electrodes: A 33-channel flexible nerve electrode array was selected, and its microfabrication process was the same as that of the implantable flexible nerve electrode array in Example 1. The implantable flexible nerve electrode includes sequentially connected pads, a 4mm solid structure, a 7mm grid structure and a 4.5mm comb structure, in which the comb structure consists of 33 4.5mm long, 15μm wide, and 3.5μm thick Composed of three-layer structure electrode wire, welding points corresponding to electrodes are arranged on the pad.

[0104] 2. Co-assemble the flexible nerve electrode array and optical fiber: select the nerve electrode array-optical fiber co-assembly method in CN107638175A, and assemble the above-mentioned flexible neural electrode...

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Abstract

The invention provides a composite neural electrode and a preparation method thereof. The composite neural electrode comprises a flexible neural electrode cured material; the flexible neural electrodecured material comprises a polymer cured material and flexible neural electrode arrays dispersed in the polymer cured material by a co-assembling effect; and an active substance is dispersed in the polymer cured material. In the invention, the active substance is dispersed in the polymer cured material coating the peripheries of flexible neural electrodes, and the composite neural electrode can be implanted into a specific brain area of the brain and carries out fixed point conveying on the loaded active substance to a target brain area so as to carry out regulation and control on cell functions of the target brain area; and meanwhile, the electrode adopting the flexible neural electrodes can record and stimulate an electrical activity signal of neurons, can be combined with technologiessuch as optogenetics and the like, and has the important application value for research in the aspects of a neural circuit, nerve diseases and the like.

Description

technical field [0001] The invention belongs to the technical field of neuroscience and biomedical instrument engineering, and specifically relates to a composite nerve electrode and a preparation method thereof, in particular to a multifunctional composite nerve electrode carrying therapeutic substances and a preparation method thereof. Background technique [0002] The 21st century is recognized by the world scientific community as the era of biology and brain science. Neuroscience is one of the mainstream directions for multidisciplinary and multilevel comprehensive research on advanced cognitive functions such as human brain language, memory, thinking, learning and attention. A core challenge of neuroscience is to understand the organization and function of neural circuits composed of many cell types, so as to treat and improve specific diseases caused by abnormalities of local nuclei in the brain, such as epilepsy, Parkinson's disease, intractable pain, Central nervous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/05A61M31/00A61B5/0478A61N1/36
CPCA61N1/0529A61M31/002A61N1/3605A61M2210/0693A61B5/291A61M2210/005
Inventor 方英田慧慧邹亮
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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