Bionic excrement and preparation method and application thereof

A feces and solvent technology, applied in the field of medical devices, can solve the problems of difficult perfusion, fast discharge, high viscosity, etc., and achieve the effects of increasing mechanical strength, accurate detection, and good biocompatibility

Active Publication Date: 2020-07-24
长春吉原生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The choice of defecation contrast medium is an important step in defecation contrast. The concentration of barium is very important. Dilute barium is easy to prepare and can coat the rectal mucosa well, but it is discharged quickly and often cannot fully display the lesion; thick barium viscosity and It is similar to normal feces, conforms to the physiological defecation process, can observe the functional activities of the disc floor muscles, detect potential lesions, and can also display the rectal mucosa well, but the preparation of thick barium is complicated, and the viscosity is too high, so it is extremely difficult to perfuse

Method used

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  • Bionic excrement and preparation method and application thereof
  • Bionic excrement and preparation method and application thereof
  • Bionic excrement and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Preparation of bionic feces and defecation contrast agent according to the present invention

[0034] 1. Preparation of recipe 1

[0035] Add 0.4kg propylene glycol, 1.2kg glycerin and 26.78kg water into the reaction kettle, stir evenly, then add 9.2kg poloxamer P407, 0.8kg poloxamer P188, 0.8kg carrageenan, 0.8kg carbomer powder Mix evenly, slowly add to the reaction kettle, set the temperature of the reaction kettle to 0°C, stir at a medium speed until a uniform solution is obtained, continue to add 0.02kg chitosan fiber to the solution, stir until the fiber is evenly dispersed in the system, The material liquid was released from the reaction kettle, and every 100g was divided into one bottle, sealed at 0°C, and irradiated with high-energy rays using an electron accelerator with a dose of 15KGy. Take 100g of the gel and add 100g of barium sulfate dry powder to mix with the prepared solution, stir evenly, and prepare a temperature-sensitive hydrogel contras...

Embodiment 2

[0041] Example 2: Index detection and development performance of the bionic feces of the present invention

[0042] From the bionic feces prepared by recipes 1-7, 5 were randomly selected for each proportion, and the gel strength (gel strength data was obtained from the test of hybrid rheometer DISCOVERY HR-1), phase transition temperature (phase transition Temperature data are measured by inversion method), response time, consistency index (consistency index is measured by NDJ-5S viscometer) and developing performance, taking the average value. The results are shown in Table 2 below:

[0043] Table 2

[0044]

[0045]According to the results in Table 2, it can be clearly seen that, without adding carrageenan and carbomer, the strength of formula 3 decreased significantly. Although it can be clearly developed when used for development, it is easily broken into blocks due to insufficient strength; In addition, recipes 5-6 only use propylene glycol or glycerin and water in ...

Embodiment 3

[0046] Embodiment 3: comparative test of the bionic feces of the present invention

[0047] 1. Effect of chitosan fiber on bionic feces

[0048] Taking recipe 1 as the object, set a control without adding chitosan fiber, and compare the surface state of the two after molding at 37°C (common camera to take pictures and observe), the results are shown in figure 1 . figure 1 It can be clearly seen that the surface of the control bionic feces without adding chitosan fiber is smooth, while the surface of the bionic feces of formula 1 is rough and uneven.

[0049] 2. Phase transition test

[0050] Place the bionic feces prepared by recipe 1 at 4°C and 37°C respectively, and observe the state changes. The results are shown in figure 2 . figure 2 It is in a solution state at 4°C and has good fluidity. When the temperature rises to 37°C, the solution undergoes a phase transition and loses fluidity.

[0051] 3. X-ray development effect test

[0052] Set up the following test gro...

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Abstract

The invention relates to the technical field of medical instruments, and discloses bionic excrement and a preparation method and application thereof. The bionic excrement comprises a temperature-sensitive material, a solvent and chitosan fibers. The temperature-sensitive bionic excrement is prepared by selecting proper materials, is in a flowable liquid state at a low temperature (below 25 DEG C),has a certain consistency, can be smoothly injected into the intestinal tract through an injector, is converted to be in a non-flowable gel state in the intestinal tract (36-39 DEG C) through a shortgelatinization process to completely lose flowability, and has the certain mechanical strength and surface roughness to stimulate the intestinal tract to produce awareness of defecation, so that a normal defecation process of the human body is simulated for discharging the excrement out of the body. Meanwhile, by adding a contrast agent, the bionic excrement is developed in the intestinal tract,X-ray radiography can be carried out after forming, and a radiography image is uniform and clear, so that the examination of a nidus area is assisted.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a bionic feces and its preparation method and application. Background technique [0002] The defecography is a method that focuses on the functional examination of the anorectum when the patient defecates, combining motion and static state. It can show the organic lesions and functional abnormalities of the department. Because functional abnormalities can only be displayed when defecation is performed, defecography can provide a reliable basis for clinical diagnosis and treatment of anorectal diseases such as constipation. [0003] The choice of defecation contrast medium is an important step in defecation contrast. The concentration of barium is very important. Dilute barium is easy to prepare and can coat the rectal mucosa well, but it is discharged quickly and often cannot fully display the lesion; thick barium viscosity and It is similar to normal feces and conforms...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/10A61K47/36A61K47/32A61K49/04
CPCA61K47/10A61K47/36A61K47/32A61K49/0404Y02A50/30
Inventor 何婉莹朱晓全王静于春暖苗冲赵鹤桐王金泽杜婧祝丽丹刘美英
Owner 长春吉原生物科技有限公司
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