Micro-fluidic chip-level extracorporeal circulation system for vascular endothelial cell mechanics and biology research
A microfluidic chip and circulatory system technology, applied in biological testing, laboratory containers, chemical instruments and methods, etc., can solve the problem of failure to realize closed-loop control of pressure or flow signal, and failure to realize endothelial cell mechanobiology Quantitative monitoring and other issues
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[0050] (1) Design the cell culture chamber height H c , width W c and length L c They are 0.5mm, 10mm and 15mm respectively, and the viscosity η of the cell culture medium is usually 0.001Pa·s. The blood pressure of common carotid artery before and after exercise intervention p(t)( image 3 (a)) and the wall shear stress τ w (t) Waveform ( image 3Substituting (b)) in formula (2a) to calculate the input flow waveform q(t) of the "sandwich" cell culture chamber, substituting into formula (2b), we can know that max(Δp(t) / p(t))=0.04n )(Such as Figure 4 shown by the solid line);
[0051] (2) For the common carotid artery system, it can be constructed as Figure 5 In the five-component lumped parameter model shown in (a), the cell culture chamber R c The afterload input impedance of Expressed as:
[0052]
[0053] where R c , R f1 , R f2 Simulate the flow resistance of the target artery segment and the total flow resistance of the vascular bed downstream of the tar...
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