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Oral medicine capable of adjusting blood lipid, raising adiponectin and nourishing liver

An adiponectin and blood lipid-regulating technology, which is applied in the field of liver-protecting oral drugs, blood lipid-regulating, and adiponectin-elevating fields, can solve the problems of liver damage and expensive western medicine.

Active Publication Date: 2020-07-07
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Drug treatment of hyperlipidemia has always been dominant, but less than 70% of people obtain satisfactory therapeutic effects. In addition, western medicines are more expensive, and some western medicines have irreversible damage to the liver, and even liver transplantation is required.

Method used

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  • Oral medicine capable of adjusting blood lipid, raising adiponectin and nourishing liver
  • Oral medicine capable of adjusting blood lipid, raising adiponectin and nourishing liver
  • Oral medicine capable of adjusting blood lipid, raising adiponectin and nourishing liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]Take by weighing 20.00 kg of the above-ground part of pearl ginseng produced in September in Taibai County, Baoji City, Shaanxi Province, add 12 times its mass concentration and reflux extraction of 70% ethanol aqueous solution for 2 times, extract for 2 hours each time, filter, combine the filtrate, concentrate, Utilize D-101 macroporous resin column chromatography to purify the concentrated solution, elute with ethanol aqueous solution with volume concentration of 30%, 70%, and 95% successively, collect the eluate with volume concentration of 70% ethanol aqueous solution, concentrate and dry to obtain 854.48g (yield: 4.3%) of the extract of the aerial part of Ginseng. Through liquid chromatography analysis, the total saponin content in the aerial part extract of the obtained Pearl Ginseng is 86.25%, wherein ginsenoside Rb 2 The content is 17.39%, ginsenoside Rb 1 The content is 4.97%, ginsenoside Rg 1 The content is 5.41%, ginsenoside Rb 3 The content of ginsenoside...

Embodiment 2

[0043] Weigh 25.20 kg of the above-ground part of pearl ginseng produced in June in Taibai County, Baoji City, Shaanxi Province, add 10 times its mass and 50% ethanol aqueous solution for reflux extraction twice, extract for 1.5 hours each time, filter, filter and merge twice The filtrate was concentrated, and the concentrated solution was purified by D-101 macroporous resin column chromatography, followed by eluting with aqueous ethanol with a volume concentration of 10%, 30%, 50%, and 95%, and collecting the ethanol solution with a volume concentration of 50%. Deliquified, concentrated and dried to obtain 630.06 g (yield: 2.5%) of the aerial part extract of ginseng. Through liquid chromatography analysis, the total saponin content in the aerial part extract of the obtained Pearl Ginseng is 90.18%, wherein ginsenoside Rb 2 The content is 19.46%, ginsenoside Rb 1 The content is 5.51%, ginsenoside Rg 1 The content is 6.32%, ginsenoside Rb 3 The content of ginsenoside Rd is 5...

Embodiment 3

[0046] Weigh 63.00 kg of the above-ground part of pearl ginseng produced in May in Taibai County, Baoji City, Shaanxi Province, add 13 times its mass of 80% ethanol aqueous solution for reflux extraction twice, extract for 2.5 hours each time, filter, filter and merge twice The filtrate was concentrated, and the concentrated solution was purified by D-101 macroporous resin column chromatography, followed by eluting with aqueous ethanol with a volume concentration of 30%, 70%, and 95%, and collecting the eluate with a volume concentration of 95% aqueous ethanol, Concentrate and dry to obtain 614.25 g (yield: 1.0%) of the aerial part extract of Ginseng. Through liquid chromatography analysis, the total saponin content in the aerial part extract of the obtained Pearl Ginseng is 81.29%, wherein ginsenoside Rb 2 The content is 18.03%, ginsenoside Rb 1 The content is 4.50%, ginsenoside Rg 1 The content is 4.78%, ginsenoside Rb 3 The content of ginsenoside Rd is 4.43%, and the con...

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Abstract

The invention discloses an oral medicine capable of adjusting blood lipid, raising adiponectin and nourishing liver. The oral medicine is prepared by using a panax japonicus overground part extract asan effective component, wherein the content of total saponins in the panax japonicus overground part extract is 80.10%-92.01%, the content of ginsenoside Rb2 is 16.12%-28.89%, the content of ginsenoside Rb1 is 2.17%-7.10%, the content of ginsenoside Rg1 is 3.73%-9.32%, the content of ginsenoside Rb3 is 2.28%-7.01%, and the content of ginsenoside Rd is 30.58%-59.07%; and the oral medicine is obtained through the steps of performing reflux extraction on panax japonicus overground parts with ethanol water, performing purification with macroporous resins, performing concentration and performing drying. The medicine disclosed by the invention does not have any toxic or side effects, can notably reduce weight, can reduce abdomen fat, can obviously reduce serum total cholesterol, serum triglyceride and serum low density lipoprotein, can control fatty liver, and can alleviate drug-induced liver injury; and in addition, the oral medicine can raise serum adiponectin, and has positive effects ofpreventing cardiovascular and cerebrovascular diseases and diabetes.

Description

technical field [0001] The invention relates to an oral medicine for regulating blood lipid, increasing adiponectin and protecting liver, in particular to an oral medicine for regulating blood lipid, raising adiponectin and protecting liver, which is made from the extract of the aerial part of Ginseng ginseng. drug. Background technique [0002] With the improvement of quality of life, the reduction of exercise (or physical labor) time and the change of eating habits, especially high-fat, high-sugar diet and alcohol consumption, the incidence of hyperlipidemia is getting higher and higher, and the patients are younger. trend. The incidence of fatty liver in people with high blood lipids is much higher than that of normal people. Simple fatty liver can develop into steatohepatitis, cirrhosis, and liver cancer. Fatty liver can induce cardiovascular disease. Studies have shown that fatty liver can lead to cardiovascular disease. The percentage of disease increases, and the pe...

Claims

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Application Information

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IPC IPC(8): A61K36/25A61K9/00A61P3/06A61P1/16A61P9/00A61P9/10A61P3/10
CPCA61K36/25A61K9/0053A61P3/06A61P1/16A61P9/00A61P9/10A61P3/10A61K2236/333A61K2236/39A61K2236/55
Inventor 姜祎徐虹郭敏宋小妹邓翀张化为黄文丽王薇
Owner SHAANXI UNIV OF CHINESE MEDICINE
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