An oral medicine for regulating blood lipid, raising adiponectin and protecting liver

An adiponectin and blood lipid-regulating technology, applied in the directions of drug delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of expensive western medicine and liver damage, and achieve the goal of reducing drug-induced liver damage, short production cycle, and reducing abdominal fat. Effect

Active Publication Date: 2022-03-18
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Drug treatment of hyperlipidemia has always been dominant, but less than 70% of people obtain satisfactory therapeutic effects. In addition, western medicines are more expensive, and some western medicines have irreversible damage to the liver, and even liver transplantation is required.

Method used

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  • An oral medicine for regulating blood lipid, raising adiponectin and protecting liver
  • An oral medicine for regulating blood lipid, raising adiponectin and protecting liver
  • An oral medicine for regulating blood lipid, raising adiponectin and protecting liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]Take by weighing 20.00 kg of the above-ground part of pearl ginseng produced in September in Taibai County, Baoji City, Shaanxi Province, add 12 times its mass concentration and reflux extraction of 70% ethanol aqueous solution for 2 times, extract for 2 hours each time, filter, combine the filtrate, concentrate, Utilize D-101 macroporous resin column chromatography to purify the concentrated solution, elute with ethanol aqueous solution with volume concentration of 30%, 70%, and 95% successively, collect the eluate with volume concentration of 70% ethanol aqueous solution, concentrate and dry to obtain 854.48g (yield: 4.3%) of the extract of the aerial part of Ginseng. Through liquid chromatography analysis, the total saponin content in the aerial part extract of the obtained Pearl Ginseng is 86.25%, wherein ginsenoside Rb 2 The content is 17.39%, ginsenoside Rb 1 The content is 4.97%, ginsenoside Rg 1 The content is 5.41%, ginsenoside Rb 3 The content of ginsenoside...

Embodiment 2

[0043] Weigh 25.20 kg of the above-ground part of pearl ginseng produced in June in Taibai County, Baoji City, Shaanxi Province, add 10 times its mass and 50% ethanol aqueous solution for reflux extraction twice, extract for 1.5 hours each time, filter, filter and merge twice The filtrate was concentrated, and the concentrated solution was purified by D-101 macroporous resin column chromatography, followed by eluting with aqueous ethanol with a volume concentration of 10%, 30%, 50%, and 95%, and collecting the ethanol solution with a volume concentration of 50%. Deliquified, concentrated and dried to obtain 630.06 g (yield: 2.5%) of the aerial part extract of ginseng. Through liquid chromatography analysis, the total saponin content in the aerial part extract of the obtained Pearl Ginseng is 90.18%, wherein ginsenoside Rb 2 The content is 19.46%, ginsenoside Rb 1 The content is 5.51%, ginsenoside Rg 1 The content is 6.32%, ginsenoside Rb 3 The content of ginsenoside Rd is 5...

Embodiment 3

[0046] Weigh 63.00 kg of the above-ground part of pearl ginseng produced in May in Taibai County, Baoji City, Shaanxi Province, add 13 times its mass of 80% ethanol aqueous solution for reflux extraction twice, extract for 2.5 hours each time, filter, filter and merge twice The filtrate was concentrated, and the concentrated solution was purified by D-101 macroporous resin column chromatography, followed by eluting with aqueous ethanol with a volume concentration of 30%, 70%, and 95%, and collecting the eluate with a volume concentration of 95% aqueous ethanol, Concentrate and dry to obtain 614.25 g (yield: 1.0%) of the aerial part extract of Ginseng. Through liquid chromatography analysis, the total saponin content in the aerial part extract of the obtained Pearl Ginseng is 81.29%, wherein ginsenoside Rb 2 The content is 18.03%, ginsenoside Rb 1 The content is 4.50%, ginsenoside Rg 1 The content is 4.78%, ginsenoside Rb 3 The content of ginsenoside Rd is 4.43%, and the con...

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Abstract

The invention discloses an oral medicine for regulating blood fat, raising adiponectin and protecting liver. The oral medicine is made of the extract of the aerial part of ginseng ginseng as an active ingredient, and the total saponin content in the extract of the aerial part of ginseng ginseng is 80.10% to 92.01%, of which ginsenoside Rb 2 The content is 16.12%~28.89%, ginsenoside Rb 1 The content is 2.17%~7.10%, ginsenoside Rg 1 The content is 3.73%~9.32%, ginsenoside Rb 3 The content is 2.28% to 7.01%, and the content of ginsenoside Rd is 30.58% to 59.07%. The medicine of the present invention has no toxic and side effects, can significantly reduce body weight, reduce abdominal fat; significantly reduce serum total cholesterol, serum triglyceride, and serum low-density lipoprotein, can prevent and treat fatty liver, and reduce drug-induced liver damage; in addition, it can increase serum lipids Linkin has a positive effect on the prevention of cardiovascular and cerebrovascular diseases and diabetes.

Description

technical field [0001] The invention relates to an oral medicine for regulating blood lipid, increasing adiponectin and protecting liver, in particular to an oral medicine for regulating blood lipid, raising adiponectin and protecting liver, which is made from the extract of the aerial part of Ginseng ginseng. drug. Background technique [0002] With the improvement of quality of life, the reduction of exercise (or physical labor) time and the change of eating habits, especially high-fat, high-sugar diet and alcohol consumption, the incidence of hyperlipidemia is getting higher and higher, and the patients are younger. trend. The incidence of fatty liver in people with high blood lipids is much higher than that of normal people. Simple fatty liver can develop into steatohepatitis, cirrhosis, and liver cancer. Fatty liver can induce cardiovascular disease. Studies have shown that fatty liver can lead to cardiovascular disease. The percentage of disease increases, and the pe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/25A61K9/00A61P3/06A61P1/16A61P9/00A61P9/10A61P3/10
CPCA61K36/25A61K9/0053A61P3/06A61P1/16A61P9/00A61P9/10A61P3/10A61K2236/333A61K2236/39A61K2236/55
Inventor 姜祎徐虹郭敏宋小妹邓翀张化为黄文丽王薇
Owner SHAANXI UNIV OF CHINESE MEDICINE
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