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High-stability water-soluble coenzyme Q10 inclusion compound and preparation method thereof

A water-soluble, clathrate technology, applied in the chemical field, can solve the problems of reducing the stability of CoQ10 clathrates, without further consideration of the instability of CoQ10 clathrates, the limitation of CoQ10 clathrates, etc.

Pending Publication Date: 2020-07-07
上海融澈水性材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some patents have also improved the inclusion rate of inclusion compounds through certain means, but the above-mentioned process method is only aimed at the problems existing in the inclusion process of CoQ10, such as inclusion amount, encapsulation rate, etc., and does not further consider CoQ10 Instability problems of clathrates in practical applications
Due to the use of starch-based inclusion wall materials for inclusion, CoQ10 enters the cavity of starch-based wall materials through certain physical means, but this entry is not irreversible. In the further application of CoQ10 inclusion compounds, especially When it is used in the fields of medical treatment, cosmetics, food and beverage, various surfactants, other fat-soluble substances, and some water-soluble substances will form a competitive relationship with CoQ10 and enter the cavity of starchy wall materials, thereby extruding CoQ10 The cavity reduces the stability of the CoQ10 inclusion compound, and the use and preservation effect of the product will be greatly reduced, which greatly limits the practical application of the CoQ10 inclusion compound

Method used

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  • High-stability water-soluble coenzyme Q10 inclusion compound and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, preparation water-soluble coenzyme Q10 clathrate

[0047] The preparation method of water-soluble coenzyme Q10 clathrate comprises the following steps:

[0048] (1) Add 95g of maltodextrin and 0.5g of Tween 80 into 475g of water, heat to 55°C, add 1g of coenzyme Q10, shear at 3000r / min for 15min at high speed, and then use 600bar high pressure in a high pressure homogenizer Homogenize 3 times, discharge, and obtain homogeneous material.

[0049] (2), add 6g of low molecular weight chitosan to the homogeneous material of step (1), after stirring and dissolving, obtain the aqueous solution of water-soluble coenzyme Q10 clathrate.

[0050] (3) Heat the water-soluble coenzyme Q10 clathrate aqueous solution in step (2) to 35°C, add 0.0475g of cross-linking agent N,N-methylenebisacrylamide, stir for 3 hours, filter, and pass through the low-pressure Spray drying to obtain the highly stable water-soluble coenzyme Q10 inclusion compound of this embodiment.

[0...

Embodiment 2

[0052] Embodiment 2, preparation water-soluble coenzyme Q10 clathrate

[0053] The preparation method of water-soluble coenzyme Q10 clathrate comprises the following steps:

[0054] (1) Add 55g of oxidized starch and 2g of Span 20 into 550g of water, heat to 70°C, add 40g of coenzyme Q10, shear at a high speed of 7000r / min for 25min, and then homogenize in a high-pressure homogenizer at 1200bar 8 times, discharge to obtain homogeneous material.

[0055] (2) Add 3 g of low molecular weight chitosan to the homogeneous material in step (1), stir and dissolve to obtain a water-soluble coenzyme Q10 clathrate aqueous solution.

[0056] (3) Heat the water-soluble coenzyme Q10 clathrate aqueous solution in step (2) to 55° C., add 0.0055 g of cross-linking agent glutaraldehyde, stir and react for 6 hours, filter, and freeze-dry to obtain the present embodiment Water-soluble coenzyme Q10 inclusion complex.

[0057] Wherein, the addition amount of the cross-linking agent is 0.01% of t...

Embodiment 3

[0058] Example 3, preparation of water-soluble coenzyme Q10 inclusion compound

[0059] The preparation method of water-soluble coenzyme Q10 clathrate comprises the following steps:

[0060] (1) Add 80g of β-cyclodextrin and 1.0g of Tween 20 into 600g of water, heat to 60°C, add 20g of coenzyme Q10, shear at 1000r / min for 50min at high speed, and then heat it in a high-pressure homogenizer at 1000bar Homogenize under high pressure for 5 times, discharge to obtain homogeneous material.

[0061] (2), add 4.5g low molecular weight chitosan to the homogeneous material of step (1), after stirring and dissolving, obtain the aqueous solution of water-soluble coenzyme Q10 clathrate.

[0062] (2) Heat the water-soluble coenzyme Q10 clathrate aqueous solution in step (1) to 45°C, add 0.024g of cross-linking agent sodium trimetaphosphate, stir and react for 5 hours, filter, and spray dry under low pressure to obtain this example Water-soluble coenzyme Q10 inclusion complex.

[0063] T...

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Abstract

The invention provides a high-stability water-soluble coenzyme Q10 inclusion compound. A preparation method comprises the following steps: heating a water-soluble coenzyme Q10 inclusion compound aqueous solution to 10-90 DEG C, adding a cross-linking agent, performing stirring reaction for 1-20 hours, and performing filtration and drying to obtain the high-stability water-soluble coenzyme Q10 inclusion compound. In the water-soluble coenzyme Q10 inclusion compound aqueous solution, an inclusion wall material of coenzyme Q10 is a starch wall material, and the content of water is 50-95% of the mass of the water-soluble coenzyme Q10 inclusion compound aqueous solution; and the addition amount of the cross-linking agent is 0.0005-0.02% of the mass of the water-soluble coenzyme Q10 inclusion compound aqueous solution. According to the invention, through an end group treatment mode of promoting cross-linking between hydrophilic end groups -OH outside the starch wall material through the cross-linking agent containing polyfunctional groups, an inlet port of the starch wall material is effectively terminated, the use stability of the water-soluble coenzyme Q10 inclusion compound is greatlyimproved, and the application field of the water-soluble coenzyme Q10 inclusion compound is further expanded.

Description

technical field [0001] The invention belongs to the field of chemistry and relates to a highly stable water-soluble coenzyme Q10 inclusion compound and a preparation method thereof. Background technique [0002] Coenzyme Q10 (CoQ10), also known as ubiquinone, is a lipophilic chemical substance endogenously synthesized in human and various animal and plant cells. It consists of a benzoquinone ring connected to a side chain containing 10 isoprenoid units. CoQ10 is an indispensable and important physiological substance in the human body. Its chemical structure determines that it has many important physiological functions in the human body. It is an important transfer substance in life activities and a key substance in the rate-limiting reaction of the mitochondrial respiratory chain. , plays an important role in cellular energy generation and enhances biological vitality. CoQ10 is a rare compound that integrates medical use, nutrition and health care. Its value and potential ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K47/69A61K8/73A61K8/02A61K8/35A23L33/00A61Q19/00
CPCA61K31/122A61K47/6949A61K8/355A61K8/0204A61K8/732A61Q19/00A23L33/00A61K2800/56
Inventor 王宇朱广东陈占周敬扩魏亚娜
Owner 上海融澈水性材料有限公司
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