Nanoparticle photothermal conversion material based on coordination of iron and dopamine and preparation method and application thereof

Abstract

The invention belongs to the technical field of photothermal conversion materials, and discloses a nanoparticle photothermal conversion material based on coordination of iron and dopamine and a preparation method and application thereof. The preparation method comprises the following operation steps of: firstly, preparing a nanoscale iron-based metal organic framework by using a hydrothermal synthesis method; and then combining the dopamine in the nanoscale iron-based metal organic framework through the action of a coordination bond by virtue of a coordination effect of phenolic hydroxyl on the dopamine and the iron on the iron-based metal organic framework, so as to obtain the nanoparticle photothermal conversion material based on coordination of the iron and the dopamine. The material can be well applied to photothermal therapy drug preparation, photoacoustic imaging, nuclear magnetic imaging, drug loading or functional modification.

Description

technical field [0001] The invention belongs to the technical field of light-to-heat conversion materials, in particular to a nano-particle light-to-heat conversion material based on iron and dopamine coordination and its preparation method and application. Background technique [0002] As one of the important methods for constructing nanomaterials, chemical self-assembly has been widely concerned and applied in molecular catalysis, energy materials, surface engineering, especially in the fields of life science and nanomedicine. In the process of self-assembly, basic structural units organize or aggregate into a stable structure through non-covalent interactions. Compared with hydrogen bonds, π–π interactions, electrostatic interactions, and dipole interactions, transition metal-ligand coordination interactions have attracted extensive attention due to their ease of design and control. Chemical self-assembly combines the abundant reactivity of transition metal ions with hig...

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Problems solved by technology

[0006] However, the current research is more focused on using the properties of the precursor raw materials to construct nanoparticles. The function of the synthesized nanoparticles depends on the properties of the precursor compounds, and it is difficult to realize the development and application of new functions, or to combine photosensitizers or Thermosensitizers and chemotherapeutic drugs loaded inside nanomaterials

These methods usually require relatively complicated synthesis steps, high energy consumption, and the photothermal conversion performance and therapeutic ability of materials are more dependent on the loading capacity of nanomaterials and the amount of loaded drugs.

At the same time, an overly complex construction scheme may introduce more biotoxic components, which limits its further application in the biomedical field

In addition, methods based on the coordination of iron and polyphenols to form nanoparticles have been partially reported (Naturecommunications, 2015, 6, 8003; Advanced healthcare materials, 2016, 5, 772; Nanoscale, 2017, 9, 12609; International Journal of Nanomedicine, 2017, 12, 7207; Small, 2018, 14, 1702700), however, this type of material does not have a stable coordination structure, and it needs to add a large amount of stabilizer to form nanoparticles during the synthesis process, so it is difficult to Morphology and particle size control

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