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Medical sealing adhesive as well as preparation method and application thereof

An adhesive and medical technology, applied in applications, pharmaceutical formulations, surgical adhesives, etc., can solve the problems of long preparation process cycle, increased detection links, large fluidity, etc., to achieve a wide clinical application range, favorable production arrangements, The effect of reducing the number of inspections

Inactive Publication Date: 2020-06-16
JIANGSU DISSUETECH MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] As far as the applicant knows, one of the commonly used medical adhesives in clinical practice is α-cyanoacrylate adhesive, but its low viscosity makes it more fluid, and it will diffuse into wounds or areas that do not need to be glued
At present, this shortcoming is mainly overcome by adding an appropriate amount of thickener, such as medical polymethyl methacrylate (PMMA), but its preparation process is long and its flexibility after polymerization is poor.
[0003] Application number CN201110065742.9, application publication number CN102178978A patent application for invention, adding α-butyl cyanoacrylate polymer as a thickener to α-butyl cyanoacrylate monomer can obviously improve this problem, however The prepared glue cannot meet the needs of more precise tissues and other parts due to polymerization heat and flexibility, and the preparation process is long (it takes 1-1.5 months to dissolve the polymer and the monomer as a whole), so it is necessary to do further improvement
[0004] In the invention patent of patent number CN201410078279.5 and authorized announcement number CN104888268B, ammonium hydroxide or alcohol aqueous solution is used to trigger the polymerization of cyanoacrylate monomers into thickeners, but even if the above triggering substances are removed in a volatile form, additional detection is required Links to ensure no residue, need to do further improvement

Method used

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  • Medical sealing adhesive as well as preparation method and application thereof
  • Medical sealing adhesive as well as preparation method and application thereof
  • Medical sealing adhesive as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The present embodiment is the preparation method of medical sealing adhesive, comprising:

[0045] The first step is to cross-link the α-octyl cyanoacrylate monomer by ultraviolet irradiation to obtain the α-octyl cyanoacrylate polymer; wherein, the conditions of ultraviolet irradiation are: the ultraviolet energy density is 10-500 mJ / cm 2 , the irradiation time is 1-48 hours; during the ultraviolet irradiation process, the alpha-octyl cyanoacrylate monomer is placed in a quartz glass tube.

[0046] The second step is ball milling the α-octyl cyanoacrylate polymer; wherein, the ball-milled α-octyl cyanoacrylate polymer is in a powder form with a particle size less than or equal to 10 μm.

[0047]The third step is to encapsulate α-octyl cyanoacrylate polymer and α-octyl cyanoacrylate monomer in an inert gas-protected container, and obtain the finished medical sealing adhesive after moist heat sterilization; wherein, α -The mass ratio of octyl cyanoacrylate monomer to α-...

Embodiment 2

[0051] This embodiment detects Example 1 of Embodiment 1.

[0052] (1) After completing the first step in Example 1, detect the relative molecular mass and distribution of the product.

[0053] With tetrahydrofuran as the eluent and polystyrene as the standard sample, the relative molecular mass and relative molecular mass distribution of the first step product of Example 1 were determined by using Agilent's 1260 HPLC equipped with a differential detector.

[0054] The result is as figure 1 Shown, the weight-average relative molecular mass of example 1 product is 290000, and relative molecular mass distribution is 2.14. This clearly shows that the product of the first step of Example 1 is an alpha-octyl cyanoacrylate polymer.

[0055] (2) Detect the viscosity of the sample in Example 1 and the control sample.

[0056] Detection method: NDJ-5S rotational viscometer is used for measurement. The test conditions of the sample of Example 1 are as follows: No. 1 rotor, rotating ...

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Abstract

The invention relates to a medical sealing adhesive as well as a preparation method and application thereof. The medical sealing adhesive is prepared from an alpha-octyl cyanoacrylate monomer and a thickening agent, wherein the thickening agent is an alpha-octyl cyanoacrylate polymer. The preparation method comprises the following steps: carrying out ultraviolet irradiation crosslinking on an alpha-octyl cyanoacrylate monomer to obtain an alpha-octyl cyanoacrylate polymer; carrying out ball milling on an alpha-octyl cyanoacrylate polymer; and packaging the alpha-octyl cyanoacrylate polymer andan alpha-octyl cyanoacrylate monomer in a container protected by inert gas, and carrying out moist heat sterilization to obtain the medical sealing adhesive finished product. The medical sealing adhesive can be used as an ocular surface sealing adhesive or a fundus sealing adhesive.

Description

technical field [0001] The invention relates to a medical sealing adhesive. The preparation method and application of the medical sealing adhesive belong to the field of medical polymer materials. Background technique [0002] According to the applicant's understanding, one of the commonly used medical adhesives in clinical practice is α-cyanoacrylate adhesive, but its low viscosity makes it more fluid, and it will diffuse into wounds or areas that do not need to be glued. At present, this shortcoming is mainly overcome by adding an appropriate amount of thickener therein, such as medical polymethyl methacrylate (PMMA), but its preparation process is long and its flexibility after polymerization is poor. [0003] Application number CN201110065742.9, application publication number CN102178978A patent application for invention, adding α-butyl cyanoacrylate polymer as a thickener to α-butyl cyanoacrylate monomer can obviously improve this problem, however The prepared glue can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06C08F120/34
CPCA61L24/06A61L2400/04C08F120/34C08L33/14
Inventor 杨勋曹彬万文倩朱健
Owner JIANGSU DISSUETECH MEDICAL TECH CO LTD
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