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Long-acting anti-flu medical mask

An anti-influenza and mask technology, which is applied in the field of long-acting anti-influenza medical masks, can solve the problems of not killing viruses, and achieve high conservatism, inhibition of survival and transmission, and high activity

Active Publication Date: 2020-05-19
安徽盒子健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] CN104757710A discloses a kind of manufacture method of household PM2.5 protective mask, specifically relates to a kind of antiviral mask with strong adsorption: the method is to place two layers of non-woven fabric on the outermost layer of the filter screen of the mask, and the non-woven fabric can To the first filtering effect; two layers of activated carbon filter paper are placed on the non-woven fabric, because the adsorption effect of activated carbon filter paper is strong, and the adsorption is selective, non-polar substances are easier to adsorb than polar substances, so it can be significantly Enhance the filtering effect of this mask: put a layer of PM2.5 level protective layer Xinothermal breathable polypropylene fiber between two layers of activated carbon filter paper, taking into account the filtering effect and comfort of the mask, but the mask itself does not have killing effect Although the anti-virus function has a certain effect of isolating viruses, it can only partially meet the requirements of general household use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The synthesis of embodiment 1 polypeptide

[0018] The 9-fluorenylmethoxycarbonyl (Fmoc) synthesis strategy was used to synthesize from the C-terminal to the N-terminal. 10mg of Rink-Amide-Resin resin (AAPPTec, product number RRZ001) was used as a carrier, and the active group of the carrier itself was connected to the carboxyl group of 5mg of the first amino acid (Fmoc-Q-NH2) protected by Fmoc.

[0019] Rinse the resin with N-methylpyrrolephrine (NMP) to remove redundant protected amino acids, add 20% piperidine / NMP solution (volume fraction) to the reactor (solid phase synthesizer) to remove the Fmoc group, react for 20min, Empty the reactor, wash the resin with 5mL NMP shaking, repeat 3 times, remove the Fmoc protection of the first amino acid residue; the exposed active amino group is connected to the carboxyl group of the next amino acid (5mg) that is amino-protected by Fmoc , forming the first peptide bond (Q-H). The above steps in this section are repeated (the...

Embodiment 2

[0020] Example 2 protein binding experiment

[0021] A / Brisbane / 10 / 2007(H3) HA protein, A / California / 04 / 2009(H1N1) HA protein, A / Canada / 720 / 2005(H2N2) HA protein, A / Anhui / 1 / 2005(H5N1) ) HA protein, A / Netherlands / 219 / 03 (H7N7) HA protein mixed with coating solution (synthetic peptide with a final concentration of 100ng / mL) coated in 96-well plate, overnight at 4°C, 1% BSA / PBS at 37 ℃ block 1h. Washed with PBST for 3 times, the serum after the first immunization was used as the primary antibody, diluted in PBST, the first dilution was 1:200, 5-fold serial dilution, and incubated at 37°C for 1.5h. Wash 3 times with PBST, the secondary antibody is HRP-labeled mouse secondary antibody, diluted in PBST, the dilution ratio is 1:3000, incubate at 37°C for 45min, wash 3 times with PBST, add TMB substrate for color development, at OD 450 UV light was detected at the place where human serum albumin was used as a control. The results are shown in Table 1 below.

[0022] Table 1 The bi...

Embodiment 3

[0024] The preparation of embodiment 3 masks

[0025]The preparation of nanofiber layer: add 1 part (parts by weight) polyamine and guanidinium salt polymer in the raw material of making gauze, 4 parts (parts by weight) polypropylene special material, 95 parts (parts by weight) polypropylene vinyl resin , mixed at 500°C for 45 minutes and granulated to form an antiviral matrix resin. The resin was processed into nanofibers with a diameter of 50nm and then processed into a sheet, and immersed in a concentration of 330ppm or 350ppm of nano-silver nitrate for 1h, followed by drying, then immersing in the antiviral polypeptide solution prepared in Example 1 for 30min at 45 degrees Celsius, and drying;

[0026] Preparation of the mask: Take the non-woven fabric sheet and laminate it on both sides of the nanofiber layer prepared above, and then press and form it at high temperature after 2 repeated superimpositions. The non-woven fabric sheet is provided with regularly formed throug...

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Abstract

The invention relates to a long-acting anti-influenza medical mask which can effectively inhibit the survival and propagation of viruses through a specially-made anti-virus layer so as to effectivelyresist influenza viruses. Meanwhile, when the air holes are prepared, interlayer gaps do not directly correspond to each other, so that airflow is effectively prevented from directly penetrating through the mask layer, and the safety of the mask is facilitated. Through the arrangement of the air holes, internal and external circulation of breathing airflow can be effectively promoted, and the oppressed feeling of breathing is reduced.

Description

technical field [0001] The invention relates to the field of medical masks, in particular to a long-acting anti-flu medical mask. Background technique [0002] Influenza virus is a representative species of Orthomyxoviridae (Orthomyxoviridae), referred to as influenza virus, including human influenza virus and animal influenza virus. Human influenza virus is divided into A (A), B (B), and C ( C) three types, which are the pathogens of influenza (flu). Among them, the antigenicity of influenza A virus is easy to mutate, causing worldwide pandemics many times. For example, in the pandemic from 1918 to 1919, at least 20 million to 40 million people died of influenza in the world; influenza B virus is also highly pathogenic to humans, but it has not been found that influenza B virus has caused a worldwide epidemic. Pandemic; Influenza C viruses only cause insignificant or mild upper respiratory infections in humans and rarely cause epidemics. Influenza A virus was successfull...

Claims

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Application Information

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IPC IPC(8): A41D13/11A41D27/28A41D31/02A41D31/30D06M15/15D01F8/06D01F1/10D06M101/20
CPCA41D13/1192A41D27/28A41D31/305D06M15/15D06M16/00D01F8/06D01F1/103D06M2101/20
Inventor 余兵生朱猛
Owner 安徽盒子健康科技有限公司
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