Membrane separation-perfusion coupled blood purification apparatus

Abstract

The invention discloses a membrane separation-perfusion coupled blood purification apparatus. The membrane separation-perfusion coupled blood purification apparatus comprises a blood inlet end, a blood outlet end, a pre-flushing liquid outlet end, a pre-flushing liquid inlet end, a plasma separation unit shell, a plasma separation membrane assembly, an inlet and outlet filtering device, a plasma perfusion unit shell, plasma perfusion adsorption resin, a primary filtering device, a secondary filtering device and an upper end cover. The core of the plasma separation unit is a plasma separation membrane, and the core of the plasma perfusion unit is plasma perfusion adsorption resin. The apparatus integrates the functions of plasma separation and plasma perfusion; after plasma separation, plasma perfusion adsorption is carried out to remove target toxins, so operation process is simplified while the safety and effectiveness of blood purification are improved, the risks of blood loss and bacterial infection caused by operation are prevented, and the treatment cost is greatly reduced; and the two functions do not need to be connected through an extracorporeal circulation pipeline, so anextracorporeal circulation blood volume is reduced, and the risks of complications such as hypotension are reduced.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a blood purification device coupled with membrane separation and perfusion. Background technique [0002] The prognosis of liver failure is extremely poor, and the case fatality rate is as high as 80%. Currently, the most effective and practical method for clinical treatment of liver failure is to use a variety of models to combine non-biological artificial liver, such as molecular adsorption recirculation system and Prometheus system. However, due to its high cost, it is difficult to popularize and apply. At present, the commonly used method is to adopt a single treatment mode such as plasma exchange, hemodialysis, plasma perfusion, etc., but it is difficult for a single mode to completely replace the liver function to effectively remove a large amount of toxic metabolites accumulated in the body and thereby activate or induce inflammatory mediators and cytokines. [0003] Plasm...

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Problems solved by technology

The process can make full use of autologous plasma, without the need for a large amount of exogenous plasma and other blood products, and there is no possibility of infection with new diseases. However, this process requires two sets of blood purification lines to be used with two devices, and there are many connections between the lines. Increase the risk of failure of the connection port, causing blood loss and bacterial infection; both the circulation line and the two devices need to be filled with blood, so the amount of blood in extracorporeal circulation is large, which increases the risk of complications such as hypotension in patients receiving treatment; The perfusion device needs to be pre-flushed before use. In order to avoid the impact on the plasma separator, after the plasma perfusion device is pre-flushed separately, it is necessary to disassemble the pipeline used for pre-flushing and then connect it to the plasma separator, which increases the complexity of the operation and requires disassembly. Increase the risk of airborne bacteria and viruses contaminating pipelines during the process

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