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Bone repair and tumor inhibition material with photothermal conversion performance and functional coating and preparation method thereof

A photothermal conversion material and photothermal conversion technology, used in coatings, pharmaceutical formulations, pharmaceutical sciences, etc., can solve the problems of easy metastasis, single function, and life-threatening bone tumors, and achieve inhibition of tumor cell growth and operation steps. Simple, osseointegration-promoting effect

Active Publication Date: 2020-04-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing artificial bone materials prepared with polyetheretherketone (PEEK) as the main raw material are mainly to improve the biological activity of the material and take into account the mechanical strength (for example, "a preparation method of bone substitute material" disclosed in CN201310137210.0 ), so it has a single function and only has the function of bone repair
[0003] Bone tumors are tumors that occur in the bone or its subsidiary tissues, threatening people's lives. The current common treatment method is to resect the lesion area, but bone tumors are very easy to metastasize, which makes patients face the bone defect caused by tumor osteotomy again. risk

Method used

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  • Bone repair and tumor inhibition material with photothermal conversion performance and functional coating and preparation method thereof
  • Bone repair and tumor inhibition material with photothermal conversion performance and functional coating and preparation method thereof
  • Bone repair and tumor inhibition material with photothermal conversion performance and functional coating and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The processing steps of the present embodiment are as follows:

[0037] (1) Preparation of substrates with electrical conductivity and light-to-heat conversion properties

[0038] Weigh 24.0g of polyetheretherketone powder and place it in a beaker, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a polyetheretherketone dispersion; weigh 6.0g of nanoscale graphene, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a graphene dispersion , the number of nano-sheets of the nano-scale graphene is 1-5 layers, and the average radial size is 200 μm; the polyetheretherketone dispersion and the graphene dispersion are mixed together, ultrasonically dispersed for 30 minutes, filtered and dried Obtain uniformly mixed polyether ether ketone and graphene mixed powder; the polyether ether ketone and graphene mixed powder is molded into a circular truncated shape by injection molding, and the processing temperature is 370 ° C. Af...

Embodiment 2

[0050] The processing steps of the present embodiment are as follows:

[0051] (1) Preparation of substrates with electrical conductivity and light-to-heat conversion properties

[0052] Weigh 24.0g of polyetheretherketone powder and place it in a beaker, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a polyetheretherketone dispersion; weigh 6.0g of nanoscale graphene oxide, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain graphene oxide Dispersion liquid, the number of nano-sheets of nano-scale graphene oxide is 1 to 5 layers, and the average radial size is 200 μm; the polyetheretherketone dispersion liquid and graphene oxide dispersion liquid are mixed together, ultrasonically dispersed for 30 minutes, and pumped Filtration and drying to obtain uniformly mixed polyetheretherketone and graphene oxide mixed powder; the polyether ether ketone and graphene oxide mixed powder is molded into a circular truncated shape by ...

Embodiment 3

[0062] The processing steps of the present embodiment are as follows:

[0063] (1) Preparation of substrates with electrical conductivity and light-to-heat conversion properties

[0064] Weigh 19.98g of polyetheretherketone powder and place it in a beaker, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a polyether ether ketone dispersion; weigh 0.02g of nano-scale black phosphorus, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a black phosphorus dispersion ; Mix the polyether ether ketone dispersion and black phosphorus dispersion together, ultrasonically disperse for 30 minutes, and obtain a uniformly mixed polyether ether ketone and black phosphorus mixed powder through suction filtration and drying; mix polyether ether ketone and black phosphorus The mixed powder is formed into a circular truncated shape by 3D printing, and its processing temperature is 370 ° C. After cooling, a matrix with electrical conductivi...

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Abstract

The invention provides a preparation method of a bone repair and tumor inhibition material with photothermal conversion performance and a functional coating and the material obtained by the method. The preparation method comprises the following process steps: (1) taking polyether-ether-ketone powder and conductive and photothermal conversion material powder as raw materials, uniformly mixing the two kinds of powder, and processing the formed mixed powder into a required shape, so as to obtain a matrix with conductivity and photothermal conversion performance; (2) grafting an active functionalgroup on the surface of the matrix with conductivity and photothermal conversion performance, then putting the matrix with the surface grafted with the active functional group as an electrode into a dispersion liquid, and forming a functional coating on the surface of the matrix through an electrophoresis technology, the dispersion liquid being composed of a liquid conductive medium, an osseointegration promoting substance and a dispersing agent; and (3) cleaning the material with the functional coating after electrophoresis with deionized water, and drying the material to remove water on thesurface, thereby obtaining the bone repair and tumor inhibition material with the photothermal conversion performance and the functional coating.

Description

technical field [0001] The invention belongs to the field of artificial bone materials, and relates to a bone repairing and tumor suppressing material with light-to-heat conversion performance and functional coating, which uses polyether ether ketone as a main raw material and a preparation method thereof. Background technique [0002] Clinically, artificial bone materials are widely used in bone repair. Existing artificial bone materials include bioceramic materials, polymer materials and composite materials. Polyetheretherketone (PEEK) is a polymer composed of repeating units containing one ketone bond and two ether bonds in the main chain structure. It is a special polymer material. Due to its excellent mechanical properties, chemical corrosion resistance, and It can withstand repeated exposure to radiation and has biocompatibility, especially the modulus of elasticity is equivalent to that of human bone tissue, so it has attracted attention in the preparation of artific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/50A61L27/54A61L27/08A61L27/12A61L27/28A61L27/32A61L27/30
CPCA61L27/08A61L27/12A61L27/18A61L27/28A61L27/306A61L27/32A61L27/50A61L27/54A61L2300/404A61L2300/416A61L2300/606A61L2400/12A61L2430/02C08L61/16
Inventor 毕瑞野何苗苗张利祝颂松侯毅
Owner SICHUAN UNIV
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