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GelMA-oxidized dextran double-network hydrogel and preparation method thereof

A technology of oxidized dextran and double network, applied in the field of hydrogel, can solve the problems of unfavorable double network synergy, low viscosity of GelMA, no cross-linking, etc., achieve good biocompatibility, simple preparation method, and reaction mild effect

Active Publication Date: 2020-04-03
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But pure GelMA has low viscosity and long crosslinking time
[0006] Currently, the two networks in dual-network hydrogels exist independently without any cross-linking between the two networks other than physical entanglement, which is unfavorable for the synergy of the dual-networks.

Method used

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  • GelMA-oxidized dextran double-network hydrogel and preparation method thereof
  • GelMA-oxidized dextran double-network hydrogel and preparation method thereof
  • GelMA-oxidized dextran double-network hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0048] The preparation method of the GelMA-oxidized dextran double network hydrogel in this example is as follows:

[0049] 1) Preparation of oxidized dextran ODEX: 5.000 g of dextran accurately weighed was placed in 400 mL of deionized water, and heated to 50° C. with magnetic stirring to dissolve to form a uniform solution. Then put 3.000g NaIO 4 Slowly add to the reaction solution in a dark environment. After stirring for 4 hours in the dark at room temperature, 2 mL of ethylene glycol was added to terminate the reaction. After stirring for 15 minutes, the product was put into a dialysis bag (Mw=14000) for dialysis for 2 to 3 days, and the water was changed 3 to 4 times a day. After the dialysis is complete, pour the solution into a petri dish, put it into a -80°C refrigerator for pre-freezing, and put it into a lyophilizer to freeze-dry to obtain a white product, which is sealed and stored for later use.

[0050] 2) Preparation of GelMA: GelMA is obtained by reacting met...

Embodiment 2

[0053] The difference between the preparation method of the GelMA-oxidized dextran double network hydrogel in this example and Example 1 is that in step 3), the solution volume ratio of GelMA:ODEX is 1:1 and mixed evenly, and the rest are the same as those in the implementation. Same as Example 1.

Embodiment 3

[0055] The difference between the preparation method of the GelMA-oxidized dextran double network hydrogel in this example and Example 1 is that in step 3), the solution volume ratio of GelMA:ODEX is 2:3 and mixed evenly, and the rest are the same as those in the implementation. Same as Example 1.

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Abstract

The invention discloses GelMA-oxidized dextran double-network hydrogel and a preparation method thereof. The preparation method comprises: 1) preparing oxidized dextran: reacting a dextran solution with an oxidizing agent to obtain oxidized dextran, 2) preparing methacrylated gelatin: reacting a gelatin solution with methacrylic anhydride to obtain a methacrylated gelatin, and 3) preparing double-network hydrogel: mixing the oxidized dextran solution with the methacrylated gelatin solution, then mixing the mixture with a photoinitiator solution to obtain a mixed solution, then standing the mixture to form gel, and carrying out ultraviolet irradiation on the obtained gel to obtain the GelMA-oxidized dextran double-network hydrogel. The photo-crosslinking double-modified GelMA-oxidized dextran double-network hydrogel is stable in structure and good in mechanical property, the preparation raw materials are safe and environmentally friendly, the preparation method is simple, the reaction conditions are mild, and the wide application prospect is achieved.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a GelMA-oxidized dextran double network hydrogel and a preparation method thereof. Background technique [0002] Hydrogels composed of natural polymer materials and their derivative polymers can be well simulated due to their high water content in their structures and their high biomimetic properties—similar physical properties to those of extracellular matrix (ECM), etc. Human tissue structure, and has been widely used in the fields of tissue engineering and biomedicine. [0003] Due to their single structure, single-network hydrogels often cannot withstand too much stress and deformation, which limits the application of hydrogels to a large extent. In order to improve the mechanical properties of the hydrogel through structural design, two different cross-linking points are introduced into the single-network hydrogel through different functional group reactions, and the doub...

Claims

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Application Information

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IPC IPC(8): C08J3/28C08J3/24C08J3/075C08L5/02C08L89/00C08B37/02
CPCC08J3/28C08J3/243C08J3/075C08B37/0021C08J2389/02C08J2405/02
Inventor 裴大婷于珊耿志杰刘群峰
Owner GUANGDONG PROV MEDICAL INSTR INST
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