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Glucoraphanin-containing composition and use thereof

A technology of glucoraphanin and composition, which is applied in the field of compositions containing glucoraphanin, and can solve problems affecting product quality, discoloration of product appearance, and reduction of glucoraphanin content

Pending Publication Date: 2020-04-03
SHENZHEN F&S BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, during the course of the study, it was unexpected that even mixtures of myrosinase and glucoraphanin raw materials (including raw materials in the form of broccoli and / or its extracts), which were present in solid form, remained during storage and holding Stability problems, manifested in the reduction of glucoraphanin content, and also lead to product appearance discoloration, bitter taste and other problems that affect product quality
[0008] Therefore, there is still a need in the prior art to overcome the stability problem of compositions comprising glucoraphanin and myrosinase, and to provide a composition comprising glucoraphanin and myrosinase that is stable and of satisfactory quality

Method used

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  • Glucoraphanin-containing composition and use thereof
  • Glucoraphanin-containing composition and use thereof
  • Glucoraphanin-containing composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of composition 1 of the present invention: mix 720 g of broccoli seed water extract (containing 13.0% glucoraphanin, from Brassica Protection Products LLC, the same below) with 296 g of horseradish powder and 10 g of sodium carbonate Evenly, 1.03 kg of composition 1 was obtained, wherein glucoraphanin accounted for 9.09%. The above composition 1 was divided into small bags according to the weight of each bag of 5 g to obtain the corresponding powder products.

[0032] (2) Preparation of control composition 1: Mix 720 g of water extract of broccoli seeds (containing 13.0% glucoraphanin) with 296 g of horseradish powder to obtain 1.02 kg of control composition 1, of which glucoraphanin accounts for 9.18% %. The above-mentioned control composition 1 was divided into small bags according to the weight of each bag of 5 g to obtain the corresponding powder products.

[0033] (3) Accelerated test: Place the above two powder products in the accelerated test bo...

Embodiment 2

[0041] (1) Preparation of tablet 1 of the present invention: mix 200 g of water extract of broccoli sprouts (containing 13.0% glucoraphanin) with 200 g of horseradish powder, 4 g of vitamin C, 10 g of sodium phosphate and 596 g of other compressed ingredients. Tablet excipients (the specific composition is starch, maltodextrin, hydroxypropyl methylcellulose, the ratio (w / w) is 5:80:2, the same below) are mixed evenly, and pressed according to the tablet weight of 0.6g / tablet, packaged Film coating, obtain about 1.02 kg tablet 1 of the present invention, wherein glucoraphanin accounts for 2.57%. The above-mentioned tablet 1 of the present invention is divided into bottles according to 60 tablets per bottle, and the bottle mouth is sealed after adding a desiccant to obtain the corresponding tablet product.

[0042] (2) Preparation of comparative agent 1: Mix 200 g of water extract of broccoli sprouts (containing 13.0% glucoraphanin) with 200 g of horseradish powder, 4 g of vitam...

Embodiment 3

[0050] (1) Preparation of tablet 2 of the present invention: 200 g broccoli seed water extract (containing glucoraphanin 13.0%), 50 g broccoli sprout powder (containing glucoraphanin 4.5%), 50 g broccoli flower Ball freeze-dried powder is mixed evenly with 250 g horseradish powder, 4 g vitamin C calcium, 10 g sodium citrate and 596 g other tableting auxiliary materials, and is pressed into tablets at a tablet weight of 0.6 g / sheet to obtain about 1.16 kg of the present invention. Agent 2, wherein glucoraphanin accounted for 2.80%. The above-mentioned tablets are divided into bottles by 60 tablets per bottle, and the bottle mouth is sealed after adding a desiccant to obtain the corresponding tablet products.

[0051] (2) Preparation of comparative agent 2: 200 g broccoli seed water extract (containing 13.0 %) of glucoraphanin, 50 g of broccoli sprout powder (containing 4.5 %) of broccoli curd, 50 g of broccoli curd Freeze-dried powder was mixed evenly with 250 g of horseradish...

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Abstract

The invention relates to a glucoraphanin-containing composition which contains a component 1 for providing glucoraphanin, a component 2 for providing myrosinase and a basic salt compound. The composition disclosed by the invention has good stability and overcomes the problems that the content of the glucoraphanin is lowered, a product is discolored and tastes bitter and the like in the prior art.The invention further relates to a pharmaceutical use of the composition.

Description

technical field [0001] The present invention belongs to the field of biomedicine, and in particular relates to a composition containing glucoraphanin. The present invention also relates to the preparation of the composition for preventing and / or treating diseases or diseases that can be prevented and / or treated by sulforaphane. Uses in products for medical conditions. Background technique [0002] According to the 2014 annual report of the World Health Organization, cancer is the main cause of global morbidity and death, poses a huge threat to people's life and health, and brings a heavy economic burden to social development. In the long process of fighting cancer, people put forward the concept of cancer chemoprevention in 1976, which refers to the strategy of using natural or synthetic chemical substances to prevent, slow down or reverse the occurrence and development of cancer. [0003] Sulforaphane (SFN), also known as sulforaphane, chemically named 1-isothiocyanate-4-m...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K47/02A61K47/12A61P35/00A61P9/00A61P31/04A61P25/00A61P25/18A61P25/24A61P25/28A61P11/00A61K31/375A61K31/70A61K36/31
CPCA61K31/70A61K47/02A61K38/47C12Y302/01147A61P35/00A61P9/00A61P31/04A61P25/00A61P25/18A61P25/24A61P25/28A61P11/00A61K31/375A61K47/12A61K36/31A61P3/10A61K2300/00A61K31/7028A61K9/2059A61K9/2054A61K9/1611A61K9/2013A61K9/2009A61K31/26A61K31/7032
Inventor 李晓龙朱志鹏邓李桂
Owner SHENZHEN F&S BIO TECH
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