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Light control combined SERS method based on micro-nano structure substrate

A micro-nano structure and light manipulation technology, applied in the field of light manipulation combined with SERS, can solve the problems of limited number of "hot spots", complicated experimental devices, limited number of captured particles, etc. Effect

Active Publication Date: 2020-03-27
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the SERS technology based on optical tweezers is mostly based on the research of light-trapping metal nanoparticles. This method utilizes the characteristic that the optical gradient force is greater than the light radiation pressure, and can directly capture particles. However, the number of captured particles is limited, and the number of "hot spots" formed It is also limited, and the experimental device used for light capture is complex, and usually requires three laser beams of capture light, probe light, and monitoring light to complete the required operations, so a gold nanoparticle aggregate SERS substrate with high capture efficiency and simple manipulation method is needed. Preparation

Method used

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  • Light control combined SERS method based on micro-nano structure substrate
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  • Light control combined SERS method based on micro-nano structure substrate

Examples

Experimental program
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Effect test

preparation example Construction

[0039] (1) Preparation of SERS substrate:

[0040] The SERS substrate can be selected from existing nano-sols, such as gold nano-sols, silver nano-sols, etc. For different analytes, different sol types and sizes of nanoparticles, there are certain differences in sensitivity.

[0041] Specifically, the nano-sol can be formed by the following methods:

[0042] 1) Preparation of gold nano sol: Place the chloroauric acid on a magnetic stirrer and heat it to boiling. The reducing agent used to configure the gold nano sol is sodium citrate solution, which is slowly added to the boiling chloroauric acid solution, and the pouring time is 35s Between ~ 50s, continue stirring and heating for 10 ~ 20 minutes. After the solution changes color, adjust the temperature and speed of the magnetic stirrer, and react for a period of time. After the reaction is complete, turn off the magnetic stirrer, and the solution is naturally cooled to room temperature. The pouring time and The continuous s...

Embodiment 1

[0054] Example 1: An application of light manipulation based on a silicon-based (linear stripe array) micro-nano structure substrate combined with a SERS method in the detection of polycyclic aromatic hydrocarbon pyrene molecules, including the following steps:

[0055] (1) Preparation of gold nano-sol: 30mL, volume fraction of 1% chloroauric acid solution are placed on a magnetic stirrer, and the temperature is adjusted to 190 degrees until boiling. Adjust the temperature of the boiling chloroauric acid until it is completely free of bubbles, then adjust the speed to 600 r / min, pour 10 mL, 5.8mM trisodium citrate solution continuously along the inner wall of the Erlenmeyer flask, and control the time within 42 seconds After the pouring is completed, the solution changes color, and the temperature is adjusted to 190 degrees. After ten minutes, the temperature is adjusted to 140 degrees, and the rotating speed is 360r / min. After 50 minutes, the final gold nanoparticle size is ab...

Embodiment 2

[0061] Example 2: An application of light manipulation based on a graphite (single cross-shaped slot) micro-nano structure substrate combined with a SERS method in the detection of polycyclic aromatic hydrocarbon pyrene molecules, including the following steps:

[0062] (1) Preparation of gold nano-sol: put 30 mL of chloroauric acid solution with a volume fraction of 1% on a magnetic stirrer, adjust the temperature to 190 degrees, and boil. Adjust the temperature of the boiled chloroauric acid to completely free of bubbles, then adjust the rotation speed to 600 r / min, pour 10 mL, 5.8mM trisodium citrate solution continuously along the inner wall of the Erlenmeyer flask, and control the time within 42 seconds After the pouring is completed, the solution changes color, and the temperature is adjusted to 190 degrees. After ten minutes, the temperature is adjusted to 140 degrees, and the rotation speed is 360r / min. After 50 minutes, it ends, and finally the particle size of the gol...

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Abstract

The invention discloses a light control combined SERS method based on a micro-nano structure substrate. The method comprises the following steps of firstly, slots with different morphologies and sizesare formed in the surface of a silicon wafer or a graphite flake; , then placing a substrate with a micro-nano structure in the gold or silver nano sol, gathering highly gathered laser beams in a slot of a micro-nano silicon-based substrate, gathering gold nano particles in the slot to form a gold nano particle aggregate, and thus obtaining the high-sensitivity SERS substrate. By utilizing the characteristic that the optical radiation pressure is greater than the gradient force, the SERS detection sensitivity is improved; the light beam for controlling the gold nanoparticles and the SERS detection light beam are the same light beam, so that the experimental detection device is simplified, and the advantage of field real-time detection of SERS is more favorably realized; and the prepared micro-nano silicon-based substrate can be repeatedly used after being cleaned, so that the detection cost is reduced, and the resource utilization rate is increased.

Description

technical field [0001] The present invention relates to the technical field of surface-enhanced Raman spectroscopy, in particular to a light manipulation method based on a micro-nano structure substrate combined with a SERS method, which improves the sensitivity of the molecules to be measured on the basis of a gold nano-sol (SERS) substrate by two An order of magnitude trace detection has broad application prospects. Background technique [0002] Surface enhanced Raman spectroscopy (SERS) is a surface enhancement effect associated with rough metal materials (such as gold, silver, etc.). SERS has high detection sensitivity and strong specificity, and can obtain the fingerprint spectrum of the measured object. It is an excellent analytical tool and has been widely used in spectral analysis, biosensing and other fields. The intensity of the SERS signal largely depends on the shape and size of the SERS substrate as well as the adsorption characteristics of the molecules to be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 张旭史晓凤辛坤马君
Owner OCEAN UNIV OF CHINA
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