Monoethyl fumarate calcium salt for eradicating gastrointestinal disease helicobacter pylori infection and application thereof
A technology of monoethyl fumarate calcium salt and monoethyl fumarate, which can be applied to medical preparations with no active ingredients, medical preparations containing active ingredients, antibacterial drugs, etc., and can solve the problem of no breakthrough progress , Difficulty in eradication, reduction in eradication rate, etc., to achieve the effects of high recovery rate of ulceration, reduction of pepsin excretion, and relief of disease symptoms
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preparation example 1
[0055] The preparation steps of monoethyl fumarate are:
[0056] In a 1000mL three-neck flask, add 200g of maleic anhydride and 145mL of absolute ethanol, start stirring, heat in a water bath to 60°C, react for 3 hours, cool to room temperature, add 2g of anhydrous aluminum chloride to the reaction flask, and heat up To 90°C, react for 2 hours, add 160mL of toluene, filter while hot, stir and cool the filtrate, there are a lot of white solids, filter to obtain monoethyl fumarate.
preparation example 2
[0058] The preparation steps of monoethyl fumarate calcium salt are:
[0059] Get monoethyl fumarate 500g, add in the reaction bottle, add 1.5 Kg pure water, add 153g calcium carbonate slowly under stirring, stir reaction 7 hours. Filter the reaction solution to remove impurities, distill off water at 70°C under reduced pressure, cool down to 5°C for crystallization for 3 hours, filter, collect crystals, and dry the obtained crystals at 60°C for 5 hours to obtain monoethyl fumarate Calcium salts.
preparation example 3
[0061] The preparation steps of Arrowhead mushroom extract are:
[0062] Take the Arrowhead mushroom, dry it, crush it, extract it with 7 times the weight of 93% (volume) ethanol at room temperature for 4 times, and then use 15 times the weight of 40% (volume) ethanol at room temperature for 1 time, each time for 48h, Filter, and extract the residue with 5 times the weight of 50% (volume) ethanol in a 50°C water bath for 4 times, 2 hours each time, combine the extracts, filter, concentrate under reduced pressure until there is no alcohol smell, and obtain the crude extract. The crude extract was diluted with an appropriate amount of distilled water to a relative density of 1.1 to 1.2 at room temperature, mixed evenly, extracted twice with equal volumes of chloroform and ethyl acetate, combined, and concentrated under reduced pressure to obtain the extract Shanci Mushroom Extract.
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