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Preparation for preventing and treating critical hyperuric acid, hyperuricemia and gout and preparation method thereof

A technology of hyperuricemia and hyperuricemia, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve problems such as deprivation, chain physiological adverse reactions, and damage to human evolution.

Inactive Publication Date: 2020-03-17
王昌勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, it will not only deprive and damage the foundation of the human body's evolution; moreover, it will cause a chain of physiological adverse reactions. The correct approach should be the opposite of reverse thinking.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0060] Specific example 1 Capsule filling: mix alkaline protease and its weight 10-70% pH7.1-9.0 dipotassium hydrogen phosphate and potassium dihydrogen phosphate in a phosphate buffer with a mixer; add enteric polymer cellulose Mix the solution evenly, put it into a spray dryer to form yellow-brown particles, and set aside. 0.001-2.0% of alkaline protease weight vitamin B6, 0.001-0.5% of organic magnesium, manganese, copper, selenium, zinc and potassium, and 0.001-1.0% of organic germanium are mixed in a mixer; Mix the soluble polymer cellulose solution evenly, put it into a spray dryer to form white particles, and set aside. The yellow-brown and white particles are blended in a mixer at a ratio of 1:1 to 6, and poured into enteric-coated capsules to obtain the finished product. Take it three times a day before meals, 1-5 capsules each time; the shelf life is 18 months when stored at 5°C, and >6 months when stored at 25°C.

specific Embodiment 2

[0061] Specific embodiment 2 food preparation: put alkaline protease, and the buffering of 10~70% pH7.1~9.0 sodium carbonate and sodium bicarbonate of its weight into the mixer and mix evenly, add enteric polymer cellulose solution to moisten and mix Evenly, use a granulator to make small yellow-brown granules, dry them in a dryer at 25-30°C, and set aside; add 0.001-2.0% of the weight of alkaline protease to vitamin B6, and organic magnesium, manganese, copper, selenium, zinc, Each 0.001-0.5% of potassium element and 0.001-1.0% of organic germanium element are put into the mixer and mixed evenly, and the enteric polymer cellulose solution is added to moisten and mix evenly, and the white granules are made into small white granules by the granulator, and put into the dryer for 35 Dry at ~55°C and set aside. Small yellow-brown and white granules are mixed in a mixer at a ratio of 1:1 to 6, and then mixed with enteric-soluble polymer cellulose solution to moisten and mix evenly....

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Abstract

The invention discloses a preparation for preventing and treating critical hyperuric acid, hyperuricemia and gout and a preparation method thereof, which belongs to the field of biochemical pharmacy.The principle is as follows: enteric slow release and alkaline buffer pairs with controllable alkalinity are applied, and alkaline protease is a macromolecular substance, is not absorbed by intestinaltracts, enters blood and has no toxic or side effect; the alkaline protease is used for assisting autologous trypsin to decompose intestinal tract digests, uric acid wrapped by the intestinal tract digests is fully exposed, and uric acid is effectively neutralized in a face-to-face mode through the alkaline buffer pairs with controllable alkalinity. The feedback mechanism that uric acid discharged from the intestinal tract is prevented from being absorbed into blood again along with sodium ions in food is achieved, and supersaturated crystallization caused by continuous rising of the blood uric acid value is effectively prevented; and a vicious circle in which uric acid crystals continuously accumulate is prevented. The intestinal weakly alkaline physiological environment is maintained, so that the blood uric acid value is maintained in a beneficial range of 300-350umol / L all the year round, and the purpose of artificially throttling and controlling the application amount of uric acidis achieved.

Description

[0001] Technical field [0002] The invention relates to a preparation and preparation method for preventing and treating critical hyperuricemia, hyperuricemia and gout; in particular, it relates to a biological product, which belongs to the field of biochemical pharmacy. [0003] technical background [0004] In my country, hyperuricemia and gout are the fourth common chronic diseases after hypertension, hyperlipidemia and hyperglycemia. In foreign countries, the effective method for the prevention and treatment of critical hyperuricemia, hyperuricemia and gout is to use its anti-substance urate oxidase in the form of injection; however, urate oxidase is a foreign protein, although it has been chemically modified to reduce However, the method of injection in the body still causes pyrogens and allergens to react to people with sensitive constitutions, resulting in harmful consequences. Domestic patent technology 200710018951.1, the application of uric acid oxidase by oral ente...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K9/48A61K31/4415A61K33/42A61K33/00A61K47/38A61P19/06A23L33/00A23L33/15A23L33/16
CPCA61K45/06A61K31/4415A61K33/42A61K33/00A61K9/4816A61P19/06A23L33/00A23L33/15A23L33/16A23V2002/00
Inventor 王昌勇
Owner 王昌勇
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