A kind of preparation method of multifunctional vascular stent

A vascular stent and a multifunctional technology, which is applied in the field of preparation of multifunctional vascular stents, can solve the problems of inflammatory reaction and poor biocompatibility, and achieve the effects of good antibacterial performance, fast deposition speed and excellent anticoagulant performance.

Active Publication Date: 2021-11-16
成都迈德克科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the rapamycin drug-eluting stents in clinical use mainly use polymers as carriers, which have poor biocompatibility and will cause a certain degree of inflammatory response, leading to clinical complications

Method used

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  • A kind of preparation method of multifunctional vascular stent
  • A kind of preparation method of multifunctional vascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of Multifunctional Vascular Stents

[0024] (1) Preparation of dopamine-coated stent

[0025] The vascular stent was ultrasonically cleaned with acetone, ethanol and distilled water for 10 minutes in sequence, and after drying, it was immersed in a 0.2 mg / ml dopamine solution with a pH of 8.0-8.5. After reacting at room temperature for 24 hours, it was fully cleaned and dried to obtain polydopamine-coated Stent.

[0026] (2) Preparation of chitosan-functionalized graphene oxide

[0027] Ultrasonic disperse graphene oxide and chitosan in MES buffer solution with pH=5~6 respectively to obtain 1mg / ml dispersion liquid respectively, take 5ml of graphene oxide and chitosan solution and mix thoroughly, add 1ml respectively 5mM of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide solution, shaking reaction for 4 hours, repeated centrifugation and water washing to remove unreacted substances, to obtain shell Functionalization of Glycans in Gr...

Embodiment 2

[0033] Preparation of Multifunctional Vascular Stents

[0034] (1) Preparation of dopamine-coated stent

[0035] The vascular stent was ultrasonically cleaned with acetone, ethanol and distilled water for 10 minutes in sequence, and after drying, it was immersed in a 0.5 mg / ml dopamine solution with a pH of 8.0-8.5. After reacting at room temperature for 24 hours, it was fully cleaned and dried to obtain polydopamine-coated Stent.

[0036] (2) Preparation of chitosan-functionalized graphene oxide

[0037] Ultrasonic disperse graphene oxide and chitosan in MES buffer solution with pH=5~6 respectively to obtain 3mg / ml dispersion liquid respectively, take 5ml of graphene oxide and chitosan solution and mix thoroughly, add 1ml respectively 5mM of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide solution, shaking reaction for 4 hours, repeated centrifugation and water washing to remove unreacted substances, to obtain shell Functionalization of Glycans in Gr...

Embodiment 3

[0043] Preparation of Multifunctional Vascular Stents

[0044] (1) Preparation of dopamine-coated stent

[0045] The stent was ultrasonically cleaned with acetone, ethanol and distilled water for 10 minutes, dried and then immersed in a 1 mg / ml dopamine solution with a pH of 8.0-8.5, reacted at room temperature for 24 hours and then fully cleaned and dried to obtain a polydopamine-coated blood vessel stand.

[0046] (2) Preparation of chitosan-functionalized graphene oxide

[0047] Ultrasonic disperse graphene oxide and chitosan respectively in MES buffer solution with pH=5~6 to obtain 5mg / ml dispersion respectively, take 5ml of graphene oxide and chitosan solution and mix thoroughly, add 1ml respectively 10mM 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide solution, shaking reaction for 4 hours, repeated centrifugation and water washing to remove unreacted substances, to obtain shell Functionalization of Glycans in Graphene Oxide.

[0048] (3) Prepa...

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Abstract

The invention discloses a preparation method of a multifunctional vascular stent. Firstly, a dopamine coating is prepared on the surface of a vascular stent through self-polymerization of dopamine; Graphene was immobilized on the surface of the dopamine-coated vascular stent to obtain a heparin-loaded vascular stent; finally, the vascular stent was immersed in a rapamycin solution to fully absorb and load rapamycin to obtain a multifunctional vascular stent. Due to the antibacterial effect of chitosan and the effect of promoting endothelial cell growth, the anticoagulant effect of heparin, the effect of selectively promoting endothelial cell growth and the antiproliferative effect of rapamycin, the vascular stent prepared by the present invention will be prepared from multiple ways Inhibit the clinical complications of stent implantation, thereby improving the application effect of vascular stents.

Description

technical field [0001] The present invention designs the field of medical devices and biological materials, and specifically relates to a method for preparing a multifunctional vascular stent. The method is used to prepare a vascular stent, and at the same time endows the stent with good antibacterial performance, anticoagulation performance, anti-proliferation performance and endothelial growth-promoting performance. , improve the clinical application effect of the stent. Background technique [0002] Cardiovascular diseases such as coronary heart disease are a serious threat to human life and health. As the main method for the treatment of coronary heart disease, vascular stent interventional therapy has the advantages of low operation cost, small trauma, and rapid postoperative recovery. However, due to the poor self-biocompatibility of the polymer coating in the traditional stent system and the delay in vascular endothelial healing caused by anti-proliferative drugs, the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/16
CPCA61L31/084A61L31/10A61L31/16A61L2300/216A61L2300/232A61L2300/416A61L2300/45C08L79/02C08L5/10
Inventor 潘长江刘恒全刘涛龚韬
Owner 成都迈德克科技有限公司
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