Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Strychnos alkaloid vesicle and preparation method thereof

A kind of technology of total alkaloids of strychnium and strychnium, which is applied in capsule delivery, microcapsules, pharmaceutical formulations, etc., can solve the problem of non-ionic surfactant vesicles not being found, and achieve improved microcirculation and large specific surface area , increase the efficacy of the drug

Active Publication Date: 2010-08-11
ZHANGZHOU PIEN TZE HUANG PHARM +1
View PDF0 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] At present, there is no report on the study of vesicles in the percutaneous absorption of traditional Chinese medicine, and there is no research report on the application of non-ionic surfactant vesicle preparation technology to total alkaloids of strychnium.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Strychnos alkaloid vesicle and preparation method thereof
  • Strychnos alkaloid vesicle and preparation method thereof
  • Strychnos alkaloid vesicle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Take 0.5g of strychnium alkaloids, 2.5g of Span 60, and 0.25g of cholesterol, dissolve them in absolute ethanol, remove the solvent by rotary evaporation (60°C), add to the ammonium sulfate buffer solution with a pH of 6.8, and stir at 20°C until the ethanol Swipe to the top, sonicate for 30 minutes, and let stand at room temperature to cool down to obtain the vesicle suspension of strychnium alkaloids.

[0098] Take 0.1g of HPMC (K-6000), 1g of glycerin, 0.5g of potassium sorbate, add 100ml of purified water to prepare a blank gel matrix, and mix the vesicle suspension and the blank gel matrix to obtain the vesicle gel matrix. glue.

Embodiment 2

[0100] Take 30g of strychnium alkaloids, 60600g of Span, and 600g of cholesterol, dissolve in ether, remove the solvent by rotary evaporation (60°C), dry in vacuum overnight, add to ammonium sulfate buffer solution with pH 6.5, hydration temperature is 60°C, hydrate After 30 minutes, process with a high-pressure homogenizer to obtain a vesicle suspension of strychnium alkaloids.

[0101] Take carbomer 941 120g, glycerol 1200g, triethanolamine 60g, menthol 60g, ethylparaben 300g, add purified water 30000ml to prepare a blank gel matrix, mix the blank gel matrix and vesicle suspension, The vesicle gel is obtained.

Embodiment 3

[0103] Take 15g of strychnium alkaloids, 40-300g of Span, 150g of cholesterol, and 140g of octadecylamine dissolved in methanol, remove the solvent by rotary evaporation (55°C), add purified water for hydration, the hydration temperature is 65°C, the hydration time is 45min, and the ultrasonic treatment is 30 minutes , to obtain the vesicle suspension of strychnium alkaloids.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a strychnos alkaloid vesicle and a preparation method thereof, and a preparation containing the strychnos alkaloid vesicle and a preparation method thereof, and belongs to the field of medicinal preparations. The strychnos alkaloid vesicle is prepared from strychnos alkaloid, a nonionic surfactant and an additive. The strychnos alkaloid vesicle is preferably prepared into an external gel preparation. The strychnos transdermal administration external preparation has unique advantages on the medicament that: a novel vesicle administration system is applied; trandermal absorption of the medicament is increased; the clinical treatment effects are enhanced; and the toxic and side effects during oral administration and parenteral administration are avoided. The strychnos alkaloid vesicle can be applied to treatment of rheumatoid arthritis, ankylosing spondylitis, and the like.

Description

technical field [0001] The invention relates to total strychnine vesicles and a preparation method thereof, a preparation containing total strychnine vesicles and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] In the clinical practice of traditional Chinese medicine for thousands of years, Nuxychia has shown remarkable curative effect in the treatment of rheumatoid arthritis. Nuxychnosae is the mature seed of Strychnos nux-vomica L or S Pierriana A.w.Hill, which has the effects of dredging collaterals, relieving pain, dispelling stagnation and swelling, and is good at treating rheumatism and other diseases. It has been clinically used for nearly a thousand years. "Surgical Quansheng Ji" says that it "can search for rheumatism in the muscles and bones, and remove phlegm poison that coagulates outside the inner membrane of the skin." "Medical Compendium of Chinese and Western Records" highly praises it, say...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K36/56A61K47/34A61P19/04A61P29/00A61K47/26
Inventor 张卫华张永丽
Owner ZHANGZHOU PIEN TZE HUANG PHARM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com