Re-stricture preventing medicinal sustained releasing bracket and its preparation

Abstract

The present invention is one kind of medicine delayed releasing blood vessel rack capable of preventing post-operation blood vessel stenosis and its preparation process. The rack consists of siphonic blood vessel rack made of Ni-Ti memory alloy or stainless steel, porous ceramic film base layer of calcium phosphate attached to the siphonic blood vessel rack, and medicine carrying degradable surface layer attached to the porous ceramic film base layer of composite biodegradable polymer and specific medicine. The preparation process includes the steps of: machining blood vessel rack with proper material; surface activation of the blood vessel rack and two-step bionic deposition; and soaking the blood vessel rack with surface porous ceramic film base layer inside the mixture solution with specific medicine, biodegradable polymer and solvent.

Description

technical field [0001] The invention relates to a drug slow-release vascular stent and a preparation method thereof, in particular to a drug slow-release vascular stent capable of preventing blood vessel restenosis after a stent operation and a preparation method thereof, belonging to the technical field of medical devices. Background technique [0002] At present, vascular stents have been successfully applied in the interventional treatment of cardiovascular and peripheral vascular occlusive lesions, and account for more than 80% of the treatment of such diseases. About 30%, the incidence of restenosis is higher when the inner diameter of the blood vessel is less than 3mm. The occurrence of vascular restenosis is related to various factors such as elastic recoil and thrombus formation in the early stage after surgery, smooth muscle migration and hyperplasia in the middle stage, and vascular remodeling in the late stage. Vascular stents containing...

AI Technical Summary

Problems solved by technology

The problem with using non-degradable materials as carriers is that, after stent implantation, there will be a large burst of drug release in the early stage, which will easily cause the blood drug concentration to exceed the poisoning limit, and the drug release amount in the later stage will not reach the effective concentration to prevent restenosis; In addition, if the compatibility of the drug with the non-degradable carrier is poor, the diffusion rate of the drug in the carrier is too slow, and there is no drug release in the initial stage of implantation, and vascular restenosis is inevitable

The problem is that such a degradable drug coating is directly coated on the polished smooth metal or polymer stent surface, and the bonding force with the stent itself is not ideal, especially after the vascular stent is implanted, the surface The drug carrier begins to degrade, the structure of the carrier will become loose, the water content will increase, and the carrier will soon begin to disintegrate, further reducing the binding force between the carrier and the stent itself, and the smooth surface of the tube-network vascular stent has no effect on the loose carrier. The protection of the carrier is easy to fall off, shortening the effective life of the drug film