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Nanometer tinidazole carbon point as well as preparation method and application thereof

A technology of nitrazole carbon dots and nitrazole carbons is applied in the field of medicine, which can solve the problems of inability to destroy the drug resistance of Gram-negative anaerobic bacteria, large size of drugs, high drug resistance, etc., so as to avoid bacterial drug resistance. Increased sexuality, shorter time-consuming, less side effects

Inactive Publication Date: 2020-02-14
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tinidazole drug has poor water solubility and relatively large size, which makes it only able to maintain a certain efficiency of sterilization in a short period of time, and due to the complex structure and impenetrable characteristics of dental plaque biofilm, normal dosage Drugs can be ineffective and must be given in high doses or repeatedly, which can eventually lead to a series of side effects such as toxicity and high drug resistance
In addition, large particles of tinidazole do not penetrate well into biofilms, so they are usually unable to destroy biofilms and lead to drug resistance of Gram-negative anaerobic bacteria, which also raises questions for the prevention and treatment of human oral diseases. great challenge

Method used

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  • Nanometer tinidazole carbon point as well as preparation method and application thereof
  • Nanometer tinidazole carbon point as well as preparation method and application thereof
  • Nanometer tinidazole carbon point as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of nano tinidazole carbon dots, comprising the following steps:

[0035] Weigh 3mmol of pure tinidazole and grind it fully with agate grinder, then dissolve it in 10mL ultrapure water, stir thoroughly for 10min, transfer the solution to a 100mL Teflon-lined autoclave, seal it and store it at 180°C, Heat the reaction at high temperature for 8 hours; then, wait for the reactor to cool down to room temperature naturally, filter the crude reaction product through a 0.22 μm polyethersulfone membrane to remove unreacted agglomerated particles, collect the liquid and dialyze it against ultrapure water for 20 hours in an 800Da dialysis bag; Finally, the dialyzed liquid was freeze-dried overnight to prepare nano-tinidazole carbon dots for further characterization.

Embodiment 2

[0037] A preparation method of nano tinidazole carbon dots, comprising the following steps:

[0038] Weigh 5mmol of pure tinidazole and grind it thoroughly with agate, then dissolve it in 20mL of ultrapure water, stir thoroughly for 50min, transfer the solution to a 100mL Teflon-lined autoclave, seal it and store it at 250°C, Heat the reaction at high temperature for 12 hours, then wait for the reactor to cool down to room temperature naturally, filter the crude reaction product through a 0.22 μm polyethersulfone membrane to remove unreacted agglomerated particles, collect the liquid and dialyze it against ultrapure water for 48 hours in an 800Da dialysis bag, Finally, the dialyzed liquid was freeze-dried overnight to prepare nano-tinidazole carbon dots.

Embodiment 3

[0040] A preparation method of nano tinidazole carbon dots, comprising the following steps:

[0041]Weigh 3mmol of pure tinidazole and grind it thoroughly with agate, then dissolve it in 30mL of ultrapure water, stir thoroughly for 20min, transfer the solution to a 100mL Teflon-lined autoclave, seal it and store it at 200°C, Heat the reaction at high temperature for 24 hours, then wait for the reactor to cool down to room temperature naturally, filter the crude reaction product through a 0.22 μm polyethersulfone membrane to remove unreacted agglomerated particles, collect the liquid and dialyze it against ultrapure water in an 800Da dialysis bag for 12 hours, Finally, the dialyzed liquid was freeze-dried overnight to prepare nano-tinidazole carbon dots.

[0042] The properties of the nano-tinidazole carbon dots prepared in the above-mentioned Examples 1 to 3 are similar, and the nano-tinidazole carbon dots prepared in Example 1 are used as an example below to illustrate its pe...

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Abstract

The invention discloses a nanometer tinidazole carbon point as well as a preparation method and application thereof and belongs to the technical field of medicines. The preparation method comprises the following steps: preparing a 0.1-0.3mol / L tinidazole solution, performing a hydrothermal reaction on the tinidazole solution at a temperature of 180-250 DEG C so as to obtain a crude product, filtering the crude product by using a membrane of which the aperture is 0.22[mu] m, performing dialysis by using a dialysis bag of which the molecular cutoff is 800Da, and performing drying, so as to obtain the nanometer tinidazole carbon point. Tinidazole is adopted as a predrug, the tinidazole medicine is prepared into a carbon point medicine through hydrothermal conditions, and the obtained tinidazole carbon point medicine has a small nanometer size and a tinidazole antibacterial function, meanwhile has selective antibacterial activity upon obligate anaerobes, and is capable of even penetratingbacterium biomembranes to achieve deep sterilization, so that the effect of the medicine can be maximized.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a nano tinidazole carbon dot and a preparation method and application thereof. Background technique [0002] Periodontitis is a chronic infectious and inflammatory disease of periodontal tissue, which is more common after the age of 35. The occurrence of periodontitis will lead to tooth loss, which can not only affect the digestion and absorption of the human body, especially the chewing function, but also reduce the function of brain cells. Vitality, leading to memory loss, accompanied by systemic diseases, such as cardiovascular disease, high blood pressure, and heart disease after a long time. Periodontitis has been confirmed to be caused by mixed infection of various periodontal pathogenic bacteria. A group of Gram-negative anaerobic bacteria are closely related to the occurrence and development of periodontitis, among which Porphyromonas gingivalis is the most ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/15C09K11/65A61K33/44A61P1/02A61P31/04B82Y20/00
CPCA61K33/44A61P1/02A61P31/04B82Y20/00C01B32/15C09K11/65
Inventor 梁高峰高社干史浩景爱华李光大冯文坡李艳杜景霞安君岭
Owner HENAN UNIV OF SCI & TECH
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