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Functional food for intervening chronic alcohol-induced small intestine injury and application of functional food

A technology for functional food and small intestine injury, applied in the direction of function, application, food composition, etc. of food ingredients, and can solve problems affecting promotion and application.

Inactive Publication Date: 2020-02-11
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is a close relationship between the molecular weight of oligochitosan and the effect of application technology, but the intervention effect and mechanism of oligochitosan on small intestinal injury induced by chronic drinking have not been reported, which affects its further application

Method used

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  • Functional food for intervening chronic alcohol-induced small intestine injury and application of functional food
  • Functional food for intervening chronic alcohol-induced small intestine injury and application of functional food
  • Functional food for intervening chronic alcohol-induced small intestine injury and application of functional food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Effects of oligochitosan on small intestinal villi, crypts and muscular layer of rats after chronic alcohol drinking

[0039] After feeding the rats with alcohol and chitosan oligosaccharides for 6 weeks, their small intestines were taken, and pathological tissue sections were made for HE staining. Refer to figure 1 It can be seen that after intragastric administration of chitosan oligosaccharides of the present invention, the problems of alcohol-induced shortening of small intestinal villi, shedding of tips, inconspicuous shape, increased depth of crypts and decreased thickness of muscular layer can be improved.

Embodiment 2

[0040] Example 2: Effect of oligochitosan on gene expression of small intestinal tight junction protein in rats after chronic drinking

[0041] Adjacent epithelial cells are connected by a junction complex composed of a variety of proteins and molecules. From the top to the basement membrane, there are tight junctions (TJ), adherens junctions, desmosome junctions, and gap junctions, etc., which together strengthen the intercellular space. Connecting function, forming the function of transmitting information channel, among which TJ is the most important. During the onset of inflammatory bowel disease, a large number of inflammatory factors produced by the intestinal mucosa will damage the intestinal epithelial cells, affect the expression and distribution of TJ protein in intestinal epithelial cells, destroy the TJ structure, and cause damage to the intestinal mucosal barrier function. refer to figure 2As shown, compared with the normal group, 6 weeks of alcohol gavage signif...

Embodiment 3

[0042] Embodiment 3: The effect of chitosan oligosaccharide on D-lactic acid and diamine oxidase in rat blood after chronic drinking

[0043] When intestinal mucosal permeability increases, large amounts of D-lactic acid (D-LA) produced by intestinal bacteria can enter the blood circulation, so it can be used as a reliable indicator of bacterial infection and increased intestinal permeability. refer to image 3 It can be seen that compared with the control group, the D-LA content in the plasma of rats fed with alcohol for 6 weeks increased significantly (P<0.01). It can be seen that alcohol damages the intestinal barrier and increases the permeability of the small intestinal mucosa, while chitosan oligosaccharide The intervention of D-LA can significantly reduce the content of D-LA in plasma (P<0.01), and restore it to a level with no significant difference from the normal group (P<0.01).

[0044] Diamine oxidase (DAO) mainly catalyzes the diamine oxidation process of histami...

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Abstract

The present invention discloses functional food for intervening chronic alcohol-induced small intestine injury and an application of the functional food. An intervention effect of chitosan oligosaccharide on the chronic alcohol-induced small intestine injury is reflected by increasing length of intestinal villi, depth of a crypt and thickness of a muscular layer and also reflected by improving gene expression quantity of a tight junction protein Occludin, reducing gene expression quantity of Claudin4, reducing D-lactic acid content and diamine oxidase activity in plasma, and reducing malondialdehyde and protein carbonyl content, thereby alleviating oxidative damages of intestinal tissues caused by alcohol; at the same time the functional food can reduce expressions of small intestine inflammatory factors IL-6, IL-1-beta and TNF-alpha and thus reduce inflammatory reactions of the small intestine tissues caused by alcohol.

Description

technical field [0001] The invention relates to a functional food for intervening small intestinal injury induced by chronic drinking and its application, belonging to the technical field of functional food. Background technique [0002] Alcohol consumption is a factor in more than 200 diseases and injuries, and most heavy drinkers experience tissue damage or organ dysfunction. 20% to 30% of heavy alcoholics suffer from alcoholic liver diseases such as alcoholic steatohepatitis and cirrhosis. Chronic alcohol consumption can have damaging effects on growth factors, cytokines, and immune function, and damage the body's organs through the inflammatory response, so identifying the source of inflammation that leads to disease progression is critical. It has been reported that the gastrointestinal tract may be an important source of inflammation in alcohol-mediated organ damage. [0003] Chitosan oligosaccharides are obtained by chemical or enzymatic hydrolysis of chitosan. Stud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125
CPCA23L33/125A23V2002/00A23V2200/32A23V2200/334A23V2250/511
Inventor 王斌姜启兴徐颖夏文水许艳顺于沛沛杨方
Owner JIANGNAN UNIV
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