Antibacterial polysaccharide fiber material and preparation method thereof

Abstract

The invention provides an antibacterial polysaccharide fiber and a preparation method thereof, and belongs to the field of polymer fibers. The preparation method comprises the following steps: firstly, adding a sodium periodate aqueous solution into a polysaccharide aqueous solution, carrying out oxidation stirring in a dark environment, and dialyzing and freeze-drying to obtain dialdehyde polysaccharide; uniformly stirring the dialdehyde polysaccharide with polyethylene oxide, a surfactant and a cosolvent to obtain a mixed solution, and then carrying out electrostatic spinning to obtain an electrospun fiber; and finally, soaking the electrospun polysaccharide fiber into an epsilon-polylysine solution for crosslinking reaction to obtain the antibacterial polysaccharide fiber material. Theantibacterial polysaccharide fiber material has excellent antibacterial performance and good biocompatibility.

Description

technical field [0001] The invention belongs to the field of polymer fibers, and in particular relates to an antibacterial polysaccharide fiber and a preparation method thereof. Background technique [0002] After the skin tissue is damaged and forms a wound, it is susceptible to microbial infection. Without effective treatment, wound healing will be delayed after infection, which may cause serious consequences such as systemic infection or even death (Amariei G, Kokol V, Boltes K, et al. on electrospun nanofibers for biomedical applications [J]. Royal Society of Chemistry Advances, 2018, 8: 28013-28023.). Therefore, infection control is a key issue in clinical wound treatment, among which the use of antibacterial wound dressings is the most widely used method. The dressing acts as a physical barrier to isolate the wound from the outside world, preventing the invasion of external microorganisms, and the antibacterial agent kills the existing bacteria in the wound. [0003]...

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Problems solved by technology

However, silver itself is toxic, which may inhibit cell growth and proliferation, induce cell apoptosis, induce cell DNA mutation, etc., and produce toxicity to cells (Hussain S M, Hess K L, Gearhart J M, et al. cells[J].Toxicology In Vitro,2005,19(7):975-983; Hussain S M,Javorina AK,Schrand A M,et al.The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion[J].Toxicological Sciences ,2006,92(2):456-463)

In addition, silver may also cause adverse reactions such as allergy, argyria, liver function damage and pain (Trop M, Novak M, Rod Is, et al.Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burnpatient[J ].The Journal of Trauma:Injury,Infection,and Critical Care.2006,60(3):648-652.)

Long-term or large-scale use may cause excessive silver accumulation in the body, seriously affecting the health of patients

Repeated use of low doses of silver may also lead to drug resistance

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