Preparation method of breast milk-based wound dressing and application thereof

Abstract

The invention discloses a preparation method of a breast milk-based wound dressing and an application thereof. The invention provides the breast milk-based wound dressing preparation method, which comprises the following steps: S1, freeze-drying breast milk, and dissolving in a biocompatible solvent to obtain a breast milk solution; wherein the concentration of the breast milk solution in the stepS1 is greater than or equal to 1 [mu] g / mL; S2, filtering and sterilizing the breast milk solution obtained in the step S1 to obtain the wound dressing. The wound dressing has relatively low immunogenicity, and does not cause additional inflammatory reaction of an organism; hydroxyl free radicals and intracellular active oxygen can be removed, the proliferation rate of cells is increased, migration of fibroblasts and endothelial cells is promoted, and the angiogenesis capacity of the endothelial cells is enhanced; M2 phenotype of macrophages is regulated and controlled, hair follicle regeneration is promoted, and healing wounds are normalized. Besides, the wound dressing is prepared from food breast milk, is green and safe, is simple and convenient in preparation process, and has a wide popularization and application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to a preparation method and application of a breast milk-based wound dressing. Background technique [0002] The skin is the largest organ in the human body, and its functions include defense against microorganisms and regulation of body temperature. Therefore, once the skin is injured, it is necessary to accelerate wound healing quickly to avoid further formation of chronic wounds. What's more, skin repair has a considerable drawback, that is, severely damaged skin can heal, but it can't regenerate, and can form scars; the formation of these scars is not only a cosmetic defect, but also prevents the normal functioning of the body. Exercise prevents the body from cooling down due to the lack of sweat glands, resulting in elevated body temperature and metabolic disorders. Although the scar looks thicker than normal skin, its elasticity is actually poorer than n...

AI Technical Summary

Problems solved by technology

[0003] Existing medicines for the treatment of wounds, Western medicine often use medicines with anti-inflammatory, antibacterial and analgesic effects, such as antibiotics, silver salts, etc., mainly anti-inflammatory, analgesic and antibacterial; but due to the large side effects, the promotion of deep wounds Poor skin regeneration ability, unsatisfactory scar repair effect and high price, so its clinical application has certain limitations

Traditional Chinese medicine often uses wound ointments that have anti-inflammatory, muscle-promoting, and heat-toxin-removing effects, such as Jingwanhong, Meiyushang ointment, and Baoshi moist burn ointment, etc.; Or clinical prescriptions, with a long history of use, mainly rely on drug experience, lack of systematic pharmacological research experimental data to demonstrate efficacy

There are also some drugs used to treat scars in the current market, such as hormone drugs, antineoplastic drugs, substance P inhibitors, cytokines and immunosuppressants; but these drugs are expensive, the production process is tedious, the effect is different, and there are certain degree of adverse reaction

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