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A long-lasting antibacterial multifunctional coating with enhanced stability and its preparation and application

A multifunctional coating and antibacterial technology, applied in the field of medical device surface coating, can solve the problems of poor coating stability, large damage to finished products, and influence of refractive index, etc., and achieve excellent bactericidal properties and good biocompatibility , The effect of good application value potential

Active Publication Date: 2022-04-26
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surface modification is to post-process the finished product, and achieve the effect by preparing a coating on the surface. This method is economical and effective, but surface modification has problems such as large damage to the original product and poor coating stability.
Bulk modification is to add functional monomers or polymers to achieve the effect during the manufacturing process. This method has high stability and good effect, but the cost is high and the addition will have a certain impact on the properties of the finished product itself, such as the refractive index.

Method used

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  • A long-lasting antibacterial multifunctional coating with enhanced stability and its preparation and application
  • A long-lasting antibacterial multifunctional coating with enhanced stability and its preparation and application
  • A long-lasting antibacterial multifunctional coating with enhanced stability and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]Synthesis of PCBDA: Dissolve 2g of acid betaine ethyl acrylate CBMA and 1g of dopamine methacrylate DOPAMA in 10mL of N,N-dimethylformamide, then add 40mg of azobisisobutyl Nitrile, after three freeze-pump-thaw cycles under the protection of argon, react at 70°C for 24h. After the reaction, precipitate twice in anhydrous ether, collect the precipitate, and dry it in a vacuum oven at 50°C for 24 hours to obtain PCBDA. The NMR of the polymer PCBDA as figure 1 , indicating that the polymer was successfully prepared.

Embodiment 2

[0047] Preparation of contact lens coating: configure the PCBDA in Example 1 into two groups of 5 mg / mL aqueous solutions and adjust the pH to 8.5, add contact lenses and then add copper ions in one group and zinc ions in the other group, after ultrasonication for 5 minutes, After 24 hours of rest in the dark, the ultrasound was taken out for 5 minutes. Then use scanning electron microscopy and photoelectron spectroscopy to observe the contact lenses without any treatment, and the contact lenses after treatment were characterized. Contact lens cross-section scanning electron microscope results are as follows figure 2 As shown in a, b, and c, it proves that copper ions or zinc ions can coordinate and chelate with the catechol group of PCBDA to form a coating on the surface of the contact lens.

Embodiment 3

[0049] Intraocular lens coating preparation: According to the operation in Example 2, the intraocular lens was processed. Then use scanning electron microscopy and photoelectron spectroscopy to observe the IOL without any treatment and characterize the IOL after treatment. Scanning electron microscope of a cross-section of an intraocular lens such as image 3 As shown in a, b, and c, it proves that copper ions or zinc ions can coordinate and chelate with the catechol group of PCBDA to form a coating on the surface of the intraocular lens.

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Abstract

The invention provides a long-acting antibacterial multifunctional coating with enhanced stability, a preparation method and application thereof. The multifunctional coating is formed by coordination and chelation of phenolic hydroxyl groups on poly(carboxylate betaine-dopamine) copolymers and inorganic metal ions in water. The coating has excellent stability due to the strong coordination and chelation adhesion ability of metal-phenol, and the carboxybetaine component has excellent bactericidal properties, resistance to bacterial adhesion and resistance to protein adhesion. While sterilizing, prevent the accumulation of bacteria and their metabolites on the surface of the material. The preparation method of the antibacterial coating only needs to add polymers and metal ions into the aqueous solution, and after being put into the base material, a coating can be formed on the surface of the base material at room temperature, and the preparation method is simple and does not damage the base material. The invention is especially suitable for eye medical devices such as contact lenses and intraocular lenses. The coating of the invention has excellent bactericidal properties, resistance to bacterial adhesion, resistance to protein adhesion and good biocompatibility.

Description

technical field [0001] The invention belongs to the field of medical device surface coatings, in particular to a long-acting antibacterial multifunctional coating with enhanced stability and its preparation and application, in particular to the application of the multifunctional coating to contact lenses or intraocular lenses. Background technique [0002] At present, the two most used eye implant / interventional medical devices are contact lens and intraocular lens (IOL). Among them, contact lenses, also called contact lenses, are lenses worn on the cornea of ​​the eye to correct vision or protect the eyes. Contact lenses not only greatly improve the appearance and convenience of patients with refractive errors such as myopia, hyperopia, and astigmatism, but also have a wide field of vision and realistic vision. Intraocular lens is a kind of artificially synthesized special lens, which is mainly used in cataract surgery. The intraocular lens is implanted into the eye to rep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D5/14C09D133/14C08F220/36C08F220/58G02B1/18A61L27/34A61L27/50
CPCC09D5/14C09D133/064C08F220/36G02B1/18A61L27/34A61L27/50A61L2430/16C08F220/58
Inventor 刘公岩李开军马莉马晶
Owner SICHUAN UNIV
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