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Sulfydryl-containing modified blood purification membrane and preparation method thereof

A technology of blood purification and thiolization, which is applied in the field of medicine, can solve the problems of blood vessel wall damage, aggravated risk of dialysis membrane incompatibility, prone to complicated lipid metabolism disorders and cardiovascular diseases, etc., and achieves a simple procedure suitable for popularization and application Effect

Active Publication Date: 2020-01-07
XIANGYA HOSPITAL CENT SOUTH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned treatments can replace part of the functions of the kidneys and promote the excretion of toxic substances in the body, patients are prone to lipid metabolism disorders and cardiovascular diseases, the most important reason of which is the damage to the vessel wall by oxidative stress and micro-inflammatory state
The patient already has oxidative stress due to the disease state, and the incompatibility of the dialysis membrane itself further increases the risk

Method used

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  • Sulfydryl-containing modified blood purification membrane and preparation method thereof
  • Sulfydryl-containing modified blood purification membrane and preparation method thereof
  • Sulfydryl-containing modified blood purification membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of a modified blood purification membrane containing sulfhydryl groups is carried out in the following steps:

[0028] 1) Preparation of aminated polyethersulfone: Measure 30mL of concentrated nitric acid and 40mL of concentrated sulfuric acid, mix and cool, slowly add 10g of polyethersulfone into the above solution, and continue to react at 65°C for 12h. After the reaction, the product was washed three times with deionized reverse osmosis water to remove unreacted nitric acid and sulfuric acid, and dried in vacuum at 80°C for 24 hours to obtain nitrated polyethersulfone (PES-NO 2 ); the SnCl of 0.089mol 2 20g and 20g of 37% HCI solution were added into 50mL absolute ethanol, and the reaction was continued at 65°C for 15min. Weigh PES-NO 2 3 g of powder was slowly added to the above solution, and the reaction was continued for 4 hours. After the reaction, the product was washed 3 times with deionized reverse osmosis water to remove unreacted hydr...

Embodiment 2

[0033] A preparation method of a modified blood purification membrane containing sulfhydryl groups is carried out in the following steps:

[0034] 1) Preparation of aminated polyethersulfone: Measure 30mL of concentrated nitric acid and 30mL of concentrated sulfuric acid, mix and cool, slowly add 10g of polyethersulfone into the above solution, and continue to react at 65°C for 10h. After the reaction, the product was washed three times with deionized reverse osmosis water to remove unreacted nitric acid and sulfuric acid, and dried in vacuum at 80°C for 24 hours to obtain nitrated polyethersulfone (PES-NO 2 ); the SnCl of 0.089mol 2 20g and 18g of 37% HCI solution were added into 50mL absolute ethanol, and the reaction was continued at 65°C for 45min. Weigh PES-NO 2 4.5 g of powder was slowly added to the above solution, and the reaction was continued for 8 hours. After the reaction, the product was washed 3 times with deionized reverse osmosis water to remove unreacted hy...

Embodiment 3

[0039] A preparation method of a modified blood purification membrane containing sulfhydryl groups is carried out in the following steps:

[0040] 1) Preparation of aminated polyethersulfone: Measure 20mL of concentrated nitric acid and 50mL of concentrated sulfuric acid, mix and cool, slowly add 10g of polyethersulfone into the above solution, and continue to react at 65°C for 7h. After the reaction, the product was washed three times with deionized reverse osmosis water to remove unreacted nitric acid and sulfuric acid, and dried in vacuum at 80°C for 24 hours to obtain nitrated polyethersulfone (PES-NO 2 ); the SnCl of 0.089mol 220g and 13g of 37% HCI solution were added into 70mL absolute ethanol, and the reaction was continued at 65°C for 30min. Weigh PES-NO 2 3.7 g of powder was slowly added to the above solution, and the reaction was continued for 6 hours. After the reaction, the product was washed 3 times with deionized reverse osmosis water to remove unreacted hydr...

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Abstract

The invention belongs to the technical field of medicines, and relates to a preparation method of a sulfydryl-containing modified blood purification membrane. The preparation method comprises the following steps: 1) preparation of aminated polyether sulfone, 2) preparation of sulfydryl polyether sulfone, and 3) preparation of a sulfydryl polyether sulfone membrane. The invention also discloses thesulfydryl-containing modified blood purification membrane prepared by the preparation method. The sulfydryl-containing modified blood purification membrane has the advantages of improvement of the oxidation resistance of a dialysis membrane, protection of leucocytes, reduction of the vascular permeability, simple preparation method, and realization of industrial batch production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a modified blood purification membrane containing mercapto groups and a preparation method thereof. Background technique [0002] Blood purification therapy (hemodialysis and hemofiltration, etc.) is widely used in acute and chronic renal insufficiency, severe pancreatitis, multiple organ failure and other critically ill patients, especially patients with chronic kidney disease need long-term blood purification therapy . Although the above-mentioned treatments can replace part of the function of the kidneys and promote the excretion of toxic substances in the body, patients are prone to lipid metabolism disorders and cardiovascular diseases. The most important reason for this is the damage to the vessel wall by oxidative stress and micro-inflammatory state. The risk is further aggravated by the patient's own oxidative stress due to the disease state, and the incompa...

Claims

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Application Information

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IPC IPC(8): B01D71/82B01D67/00B01D69/02B01D71/68
CPCB01D67/0006B01D67/0009B01D69/02B01D71/68B01D71/82
Inventor 府晓汤赐
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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