Application of common fenugreek seed extract and extraction method thereof

Abstract

The invention discloses an application of a common fenugreek seed extract and an extraction method thereof. The tests prove that a fenugreek ethanol extract can promote GLUT4 to transpose to a membrane by activating an AMPK signal path; finally, the glucose uptake capability of C2C12 cells is improved; therefore, the common fenugreek seed extract can be used for preparing products for improving the glucose uptake capacity of skeletal muscle cells, AMPK agonists and products with a hypoglycemic effect, can be further used for preparing products for treating and / or preventing obesity, insulin resistance and diabetes mellitus, contributes to research and development of a new generation of antidiabetic drugs taking AMPK as a new target, and brings good news to human health.

Description

technical field [0001] The invention belongs to the field of plant extraction, in particular to fenugreek extract and its application. Background technique [0002] With the development of urbanization and changes in human life, the number of diabetic patients in my country ranks first in the world. In low- and middle-income countries, 21% of deaths from ischemic heart disease and 13% of deaths from stroke had hyperglycemia. At the same time, diabetes can also induce chronic kidney disease. Studies have linked diabetes to cancers such as breast, pancreatic, and colorectal. Excessive liver gluconeogenesis in patients with type 2 diabetes leads to excessive sugar production in the body, and the limited ability of skeletal muscle to absorb glucose results in high fasting blood sugar. Therefore, improving glucose utilization may be an effective treatment for type 2 diabetes and its complications. means. [0003] At present, drugs used clinically to treat type 2 diabetes, suc...

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Problems solved by technology

[0003] At present, drugs used clinically to treat type 2 diabetes, such as biguanides (metformin), sulfonylureas (glimepiride), dipeptidyl peptidase 4 (DPP4) inhibitors (vildagliptin), Oxisome proliferator-activated receptor gamma (PPARγ) agonist (pioglitazone), alpha glucosidase inhibitor (acarbose), glucagon-like peptide 1 (GLP1) analog (liraglutide), etc. Although it has a good hypoglycemic effect, it is often accompanied by adverse reactions such as hypoglycemia, weight gain, edema, lactic acidemia, flatulence, etc.

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