A kind of analysis method of elagolix sodium raw material and its synthetic intermediate
A technology for analysis of elagolix sodium and its analysis method, which is applied in the field of analysis of elagolix sodium raw materials and its synthetic intermediates, can solve the problems of lack of reference analysis standards, obstacles to product application and promotion, etc., to ensure quality Controllability, reduce detection cost, improve the effect of response and symmetry
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0046] 1. Instruments and conditions:
[0047] High performance liquid chromatography: Agilent 1260Ⅱ;
[0048] Chromatographic column: Kromasil-Eternity-5-C18 250*4.6mm;
[0049] Mobile phase A: 0.01mol / L potassium dihydrogen phosphate solution (containing 0.05% triethylamine, adjusted to pH=6.0 with phosphoric acid);
[0050] Mobile phase B: acetonitrile;
[0051] Mobile phase A: mobile phase B=95:5 (v:v);
[0052] Flow rate: 1.0mL / min;
[0053] Column temperature: 30°C;
[0054] Detection wavelength: 210nm;
[0055] Injection volume: 10μL;
[0056] 2. Implementation steps:
[0057] Weigh 100 mg of elagolix sodium, 10 mg of each intermediate and starting material, respectively, and place in a 100 mL measuring bottle, dissolve and constant volume, as the test solution. Inject 10 μL of the above solution into a high-performance liquid chromatograph, record the chromatogram, and the results are as follows: figure 1 .
[0058] Depend on figure 1 It can be seen that the r...
Embodiment 2
[0060] 1. Instruments and conditions:
[0061] High performance liquid chromatography: Agilent 1260Ⅱ;
[0062] Chromatographic column: Kromasil-Eternity-5-C18 250*4.6mm;
[0063] Mobile phase A: 0.02mol / L potassium dihydrogen phosphate solution (containing 0.05% triethylamine, adjusted to pH=6.0 with phosphoric acid);
[0064] Mobile phase B: acetonitrile;
[0065] Mobile phase A: mobile phase B=95:5 (v:v);
[0066] Flow rate: 1.0mL / min;
[0067] Column temperature: 30°C;
[0068] Detection wavelength: 210nm;
[0069] Injection volume: 10μL;
[0070] 2. Implementation steps:
[0071] Weigh 100 mg of elagolix sodium, 10 mg of each intermediate and starting material, respectively, and place in a 100 mL measuring bottle, dissolve and constant volume, as the test solution. Inject 10 μL of the above solution into a high-performance liquid chromatograph, record the chromatogram, and the results are as follows: figure 2 .
[0072] Depend on figure 2 It can be seen that t...
Embodiment 3
[0074] 1. Instruments and conditions:
[0075] High performance liquid chromatography: Agilent 1260Ⅱ;
[0076] Chromatographic column: Kromasil-Eternity-5-C18 250*4.6mm;
[0077] Mobile phase A: 0.01mol / L potassium dihydrogen phosphate solution (containing 0.05% triethylamine, adjusted to pH=6.0 with phosphoric acid);
[0078] Mobile phase B: acetonitrile;
[0079] Mobile phase A: mobile phase B=95:5 (v:v);
[0080] Flow rate: 1.0mL / min;
[0081] Column temperature: 40°C;
[0082] Detection wavelength: 210nm;
[0083] Injection volume: 10μL;
[0084] 2. Implementation steps:
[0085] Weigh 100 mg of elagolix sodium, 10 mg of each intermediate and starting material, respectively, and place in a 100 mL measuring bottle, dissolve and constant volume, as the test solution. Inject 10 μL of the above solution into a high-performance liquid chromatograph, record the chromatogram, and the results are as follows: image 3 .
[0086] Depend on image 3 It can be seen that the...
PUM
Property | Measurement | Unit |
---|---|---|
length | aaaaa | aaaaa |
diameter | aaaaa | aaaaa |
particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com