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Application of regallily glycoside A to preparation of antidepressant drug

An antidepressant and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve strong effect, antidepressant effect, and good protective effect

Inactive Publication Date: 2019-09-17
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the application of monomer components such as lilyroside A in the preparation of drugs for the prevention or treatment of depression.

Method used

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  • Application of regallily glycoside A to preparation of antidepressant drug
  • Application of regallily glycoside A to preparation of antidepressant drug
  • Application of regallily glycoside A to preparation of antidepressant drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Study on the Protective Effect of Lilyoside A on SH-SY5Y Cells Injured by Corticosterone

[0018] 1.1 Cell culture

[0019] SH-SY5Y cells were purchased from the Institute of Materia Medica, Chinese Academy of Medical Sciences. The cells to be resuscitated were taken out from the -80°C refrigerator or liquid nitrogen tank, and quickly thawed in a preheated constant temperature water bath at 37°C. Transfer the thawed cell solution in the cryopreservation tube to a 15 mL centrifuge tube prepared in advance containing 4 mL of DMEM complete culture solution containing 10% FBS and 1% double-antibody (penicillin, streptomycin), centrifuge at 800 r / min for 5 min, discard Remove the supernatant, add 6mL DMEM complete culture solution, mix well, transfer the cell solution to a 100mm culture dish or a 25cm culture bottle, gently shake the culture dish or culture bottle to make the cell solution evenly disperse, place in a place containing 5% CO 2 , cultivated in an incubator at ...

Embodiment 2

[0046] Antidepressant Pharmacodynamics Experiment of Lilyoside A in Vivo

[0047] 1.1 Experimental materials and grouping

[0048] Male SD rats, weighing 240±10g, were provided by Hunan Slack Jingda Experimental Animal Co., Ltd.

[0049] In an SPF environment with room temperature (25±2)°C, relative humidity of 50%±5%, and light / dark cycle of 12h / 12h, adaptive feeding was carried out for 5 days. Normal rats were randomly divided into 6 groups according to body weight, 12 in every group, i.e. blank control group, positive drug fluoxetine group (1.8mg / kg / day), lilyoside A high (30mg / kg), middle (15mg / kg), low (7.5mg / kg) dose group. Except for the blank group, they were reared in single cages and received various stress stimuli. The stimulation methods included: 24h fasting, 24h water deprivation, black and white inversion, 4°C ice bath for 5min, tail clamping for 1min, wet litter, empty cage for 24h, The cage is tilted at 45 degrees, and the noise is 3 hours. Give 1 or 2 ki...

Embodiment 3

[0066] Preparation of Lilyoside A Tablets

[0067] Heat and melt 80g of polyethylene glycol 4000, add 20g of lilyside A while stirring, mix and cool, crush the solidified product obtained after cooling, add 185g of starch, mix well to make granules, add 15g of sodium carboxymethyl starch, Magnesium stearate is mixed in an appropriate amount, and pressed into tablets to obtain wangbaiheside A tablets.

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PUM

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Abstract

The invention discloses application of a regallily glycoside A to preparation of an antidepressant drug. A cell model and an animal model are adopted for researching the antidepressant activity of the regallily glycoside A component. Test results show that the regallily glycoside A has good protecting activity on SH-SY5Y cells with damaged corticosterone, and the mechanism of the regallily glycoside A is possibly related to apoptosis of inhibitory neuron cells; the regallily glycoside A can obviously shorten the dead time of rat forced swimming and increase the frequency of open field autokinetic movement. It is shown that the regallily glycoside A has a strong antidepressant effect, which exploits a new field for application of monomer components of lilies and other medicinal materials, and the application prospects are broad.

Description

technical field [0001] The present invention relates to the application of lilyoside A, in particular to the application of lilyoside A in the preparation of antidepressant drugs. Background technique [0002] Depression is a common mood disorder, which can be caused by various reasons. The main clinical feature is marked and persistent low mood, and the low mood is not commensurate with the situation. In severe cases, suicidal thoughts and behaviors may appear. Most cases have a tendency to relapse, and most of each attack can be relieved, and some may have residual symptoms or become chronic. The World Health Organization reports that more than 350 million people worldwide suffer from depression, and by 2020 depression may become the second leading disease after heart disease. With the rapid development of social economy, the pace of life is accelerated, people's pressure increases, and various emotional impacts increase, resulting in an increase in the incidence of depre...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P25/24
CPCA61K31/7032A61P25/24
Inventor 袁志鹰黄惠勇吴华英李静夏帅帅
Owner HUNAN UNIV OF CHINESE MEDICINE
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