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Nano metal organic framework cavitation material, synthetic method and application

An organic framework and nano-metal technology, which is applied in the direction of medical preparations containing active ingredients, splitting materials, wave energy or particle radiation treatment materials, etc., can solve the problem of low enrichment rate of long-term circulating tumor sites and difficulties in cavitation therapy. To achieve the desired therapeutic effect, poor solubility of active ingredients and other problems, to achieve the effect of reducing the amount of drugs used, improving the efficacy of tumor treatment, and increasing permeability

Active Publication Date: 2019-08-16
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems that the active ingredients of the existing cavitation agents have poor solubility, it is difficult to achieve long-term circulation in the blood, and the enrichment rate at the tumor site is not high, which makes cavitation therapy difficult to achieve the desired therapeutic effect. The present invention provides A nano-metal-organic framework cavitation material and a preparation method of the material. The metal-organic framework material and a cavitation agent are used to form a composite, which not only improves the water solubility of the active ingredient of the cavitation agent, but also improves the enrichment at the tumor site, and improves Effects of cavitation therapy

Method used

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  • Nano metal organic framework cavitation material, synthetic method and application
  • Nano metal organic framework cavitation material, synthetic method and application
  • Nano metal organic framework cavitation material, synthetic method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0036] The preparation steps of the nano metal organic framework cavitation material in this example are as follows:

[0037] 1) using methanol as a solvent, preparing a zirconium chloride solution with a molar concentration of 20mmol / L as the metal source mother liquor; in addition using methanol as a solvent, preparing a terephthalic acid methanol solution with a molar concentration of 40mmol / L as the organic ligand mother liquor;

[0038] 2) Take 10mL each of the metal source mother liquor and the organic ligand mother liquor, mix them evenly, and place them in a 50mL reactor. The molar ratio of the metal source to the organic ligand in the mixed liquor is 1:2; After reacting in an oven at 50°C for 24 hours, take it out, centrifuge and dry to obtain a dry product;

[0039]3) According to the mass ratio of 1:3, weigh the perfluorohexane and the dried product successively in a dry Erlenmeyer flask, add an equal volume of dichloromethane, (the volume ratio of the added volume ...

Embodiment 2

[0041] The preparation steps of the nano metal organic framework cavitation material in this example are as follows:

[0042] 1) Using N,N-dimethylformamide solution as a solvent, prepare a ferric chloride solution with a molar concentration of 10mmol / L as the metal source mother liquor; also use N,N-dimethylformamide solution as a solvent to prepare The p-tetrakis (4-carboxyphenyl) porphin with a molar concentration of 30mmol / L is used as the organic ligand mother liquor;

[0043] 2) Take 10 mL each of the metal source mother liquid and the organic ligand mother liquid, and mix them uniformly and place them in a 50 mL reaction kettle. The molar concentration ratio of the metal source mother liquid and the organic ligand mother liquid in the mixed liquid is 1:3; The reaction kettle was placed in an oven at 90°C for 24 hours and then taken out, centrifuged and dried to obtain a dry product;

[0044] 3) Weigh 1,1,1,3,3-pentafluorobutane and the dried product sequentially accord...

Embodiment 3

[0050] The preparation steps of the nano metal organic framework cavitation material in this example are as follows:

[0051] 1) Using ethanol as a solvent, preparing a zirconium chloride solution with a molar concentration of 10mmol / L as the metal source mother liquor, and also using ethanol as a solvent, preparing a trimesic acid ethanol solution with a molar concentration of 20mmol / L as the organic ligand mother liquor;

[0052] 2) Take 20mL of the metal source mother liquor and the organic ligand mother liquor respectively, mix them uniformly and place them in a 100mL reactor, the molar concentration ratio of the metal source mother liquor and the organic ligand mother liquor in the mixed liquor is 1:2; The reaction kettle was placed in an oven at 70°C for 12 hours and then taken out, centrifuged and dried to obtain a dry product;

[0053] 3) Weigh the perfluorobutane and the dried product sequentially according to the mass ratio of 1:4 in a dry Erlenmeyer flask, add an eq...

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Abstract

The invention discloses a nano metal organic framework cavitation material, a synthetic method and an application, and belongs to the field of ultrasonic cavitation materials. The material is capableof using a nano metal organic framework as a carrier, and using a cavitation agent active component as a carrying object. The preparation method for the material comprises the following steps: 1) enabling a metal source and an organic ligand to be dissolved in a solvent, to obtain metal source mother liquor and organic ligand mother liquor; 2) mixing the metal source mother liquor and the organicligand mother liquor obtained in the step 1) in proportion, performing a heating reaction, centrifugally-separating, and drying, to obtain a dry product; and 3) enabling the obtained dry product and the cavitation agent active component to be dispersed in the solvent, after stirring, centrifugally-separating, and drying. Compared with lipid bubbles used in the prior art, the nano metal organic framework cavitation material is capable of remarkably improving stability, prolonging in-vivo circulating time, improving an enrichment ratio of the material in a tumor site, and improving the curativeeffect of tumor therapy.

Description

technical field [0001] The invention belongs to the field of ultrasonic cavitation materials, and in particular relates to a nanometer metal organic framework cavitation material, a synthesis method and an application. Background technique [0002] At present, nanocarrier technology has been widely used in the field of biomedicine. Due to the rapid growth and abnormal vasculature of tumors, nanocarriers can accumulate at tumor sites through the penetration and retention (EPR) effect. The main bottleneck is to increase the enrichment rate at the tumor site, and the accumulation analysis of tumors shows that only a small part of the injected nanocarriers can reach the tumor tissue (about 0.7%). Furthermore, there has been no significant improvement in this parameter over the past few decades. Tumors in different patients or in different regions of the same patient will also cause uneven distribution of nanocarriers in the tumor due to tumor heterogeneity. In addition, higher...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/22A61P35/00C08G83/00
CPCA61K41/0033A61K49/223A61P35/00C08G83/008
Inventor 黄品同张涛
Owner ZHEJIANG UNIV
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