Soapberry in-situ gel preparation for treating candida albicans vaginitis and preparing method thereof
A candida-resistant, in-situ gel technology, which is applied in the direction of antifungal agents, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low purity of saponins, achieve simple preparation, reduce Relapse rate, the effect of prolonging the effective residence time of drugs
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preparation example Construction
[0042] Preparation of Sapindus water extraction and fermentation concentrate:
[0043] Grind the dried Sapindus fruit peel to 20-60 mesh, extract the powder and water at a mass ratio of 1:3 for 6 hours at 40°C, and filter to obtain the first filtrate and filter residue. Under the same temperature conditions, extract the filter residue with water at a ratio of 1:2 for 4 hours, filter to obtain the second filtrate, discard the filter residue, and combine the two filtrates to obtain the crude filtrate of Sapindus saponin. The crude filtrate was centrifuged at 6000r / min for 10min to obtain the aqueous extract of Sapindus chinensis, which was concentrated 6 times in an evaporation device to obtain the concentrated solution of Sapindus saponin. Wine dry yeast was selected as the fermentation strain, and it was fermented at 30°C for 4 days with 1.0% inoculum to obtain the concentrated liquid of Sapindus water extraction fermentation.
Embodiment 1
[0045]This implementation provides a preparation method of Sapindia in situ gel preparation for the treatment of Candida albicans vaginitis, wherein the Sapindia in situ gel preparation includes the following components by weight: 50 parts of Sapindia in situ Fermentation concentrate (20mg / mL is recorded as saponin), 20 parts of poloxamer 407, 3 parts of poloxamer 188, 2 parts of polyethylene glycol 400, distilled water to make up to 100 parts, Sapindus in situ gel The concentration of Sapindus saponin in the preparation is 10 mg / mL.
[0046] The preparation method of the Sapindus in situ gel preparation of the present embodiment is as follows:
[0047] At 4°C, weigh polyethylene glycol 400 in parts by weight and dissolve it in 50 parts of sapindus water-extracted fermentation concentrate, mix well, add poloxamer 407 and poloxamer 188 to swell completely, continue to add distilled water To 100 parts, after mixing, obtain Sapindus in situ gel preparation.
Embodiment 2
[0049] This implementation provides a method for preparing a Sapindia in situ gel preparation for the treatment of Candida albicans vaginitis, wherein the Sapindia in situ gel preparation includes the following components by weight: Sapindiae water extraction fermentation concentration 50 parts of solution (30 mg / mL is recorded as saponin), 20 parts of poloxamer 407, 3 parts of poloxamer 188, 2 parts of polyethylene glycol 400, distilled water to make up to 100 parts, Sapindus in situ gel The concentration of Sapindus saponin in the preparation is 15mg / mL.
[0050] The preparation method of the Sapindus in situ gel preparation of the present embodiment is as follows:
[0051] At 5°C, weigh polyethylene glycol 400 in parts by weight and dissolve it in 50 parts of sapindus water-extracted fermentation concentrate, mix well, add poloxamer 407 and poloxamer 188 to swell completely, continue to add distilled water To 100 parts, after mixing, obtain Sapindus in situ gel preparation...
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