A kind of superabsorbent polymer hydrogel antibacterial sponge and its preparation method and application

Abstract

The invention relates to a preparation method and an application of superabsorbent macromolecular hydrogel antibacterial sponge. The sponge is three-dimensional reticulated porous sponge with chitosanas a framework, a superabsorbent polymer combined with an antibacterial agent sustained-release carrier as branched chains and flexible-structure macromolecules or polymers as a cross-linking agent between the branched chains, and the antibacterial agent is loaded on the antibacterial agent sustained-release carrier. The sponge can be prepared by a one-pot method. The product has a multichannel structure, has a superabsorbent property, and retains the overall structure and a certain mechanical strength after absorbing water. Growth factors or antibacterial drugs can be loaded physically or chemically, so the product has good antibacterial and bactericidal effects. The material can be used for emergency hemostasis for large arteriovenous hemorrhage, and has the effect better than conventional materials on the market. The superabsorbent macromolecular hydrogel antibacterial sponge has the advantages of simple preparation process, low cost, outstanding hemostatic effect, good safety, noheat production and no residue, and has significant medical value and industrial potential.

Description

technical field [0001] The invention relates to an antibacterial first-aid biological material for hemostasis, in particular to a superabsorbent polymer hydrogel antibacterial sponge for first-aid hemostasis. Background technique [0002] Hemostasis is an important part of surgery, especially trauma first aid. The current hemostatic materials mainly achieve the purpose of hemostasis by promoting the body's own coagulation function, supplementing exogenous coagulation factors, inhibiting fibrinolysis and contracting blood vessels. Trauma bleeding and severe complications are still the leading causes of death. Massive blood loss renders the victim vulnerable to hypothermia, coagulopathy, infection, and multiple organ failure. Effective hemostasis will improve survival and reduce major bleeding complications. It is estimated that at least one third of all trauma deaths are due to lack of adequate hemostasis. Emergency hemostatic agents are different from general hemostatic a...

AI Technical Summary

Problems solved by technology

When they are used in the hospital, the hemostatic effect is acceptable, but there are obvious shortcomings when used in self-rescue and mutual rescue: for example, fibrin glue is derived from blood, the cost is high, and it is easy to infect diseases; collagen relies solely on the activation of platelets to stop bleeding , the hemostatic effect is limited, and the mechanical strength and tissue adhesion are poor; porous zeolite and Trauma DEX will release a large amount of heat energy after absorbing blood water, which will cause tissue burns; carboxymethylcellulose soluble gauze cannot degrade on the wound surface, and the hemostatic ability is limited

The significant blood coagulation effect brought about by simple water absorption and concentration, but limited by the process, dosage form and other factors, did not exert the ideal hemostatic effect, and the material itself has no antibacterial function

The materials disclosed in patent ZL 03153260.8 and patent ZL 200410096825.4 are not biodegradable because sodium polyacrylate or polyacrylamide superabsorbent molecules are not biodegradable, so they are easily washed away by blood flow when bleeding arteries or veins are injured. The water absorption is quickly saturated, the hemostatic effect is limited, and the material itself has no antibacterial function

None of the superabsorbent polymer modified macromolecules disclosed in the above patents can solve the dosage form problem. The prepared materials are in the form of powder or doped with powder, which not only limits the function of the material as a whole, but also brings cleaning difficulties and residual problems in the body.

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