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Povidone iodine composition and preparation method and external preparations thereof

A technology of povidone iodine and external preparations, applied in the field of medicine, can solve the problems of no synergistic antifungal or antitumor effect of povidone iodine and glycerin, short storage time, low stability of povidone iodine, etc., and achieve Good antibacterial effect, enhanced synergistic effect, high stability effect

Inactive Publication Date: 2019-07-19
ZHONGSHAN WANHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although most disinfection preparations contain povidone-iodine and glycerin, only povidone-iodine has antibacterial or anti-tumor effects, and no synergistic anti-fungal or anti-tumor effects of povidone-iodine and glycerin with different molecular weights have been seen. related reports
In addition, in the prior art, the antibacterial effect of povidone-iodine disinfectant preparations still needs to be improved, the stability of povidone-iodine is low, and the storage time is short, and there is no combination of povidone-iodine and glycerin in the prior art. Application of combination in antitumor

Method used

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  • Povidone iodine composition and preparation method and external preparations thereof
  • Povidone iodine composition and preparation method and external preparations thereof
  • Povidone iodine composition and preparation method and external preparations thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Basic Example 1: Preparation method of povidone-iodine composition

[0033] The preparation method comprises the following steps:

[0034] (1) Preparation of polyvinylpyrrolidone (PVP): Heat the solvent water bath to 40-80°C, add N-vinylpyrrolidone and initiator while stirring, and the volume ratio of N-vinylpyrrolidone and solvent is 0.25-1: 1. The final concentration of the initiator is 0.2%-3%, stirring for 30-60 minutes to obtain polyvinylpyrrolidone, using an Ubbelohde viscometer to measure the intrinsic viscosity of polyvinylpyrrolidone, and calculate the molecular weight of polyvinylpyrrolidone;

[0035] Described solvent is the one in dehydrated alcohol, purified water, Virahol and benzene;

[0036] The initiator is azobisisobutyronitrile or hydrogen peroxide-ammonia water mixed solution, and the ratio of hydrogen peroxide-ammonia water mixed solution is: 5mL of 30% hydrogen peroxide by volume and 10mL of 10% by volume of ammonia.

[0037] The polyvinylpyrrol...

Embodiment 2

[0050] Embodiment 2: A kind of povidone-iodine composition

[0051] The composition comprises in parts by weight: 2 parts of povidone-iodine and 80 parts of glycerin, that is, the mass ratio of glycerin and povidone-iodine is 40:1;

[0052] The weight average molecular weight of polyvinylpyrrolidone in described povidone iodine is 1.95 * 10 4 Da, the available iodine content is 10.17%, namely P4.

[0053] This composition was prepared according to the method described in Basic Example 1, with the difference from Basic Example 1 in that:

[0054] (1) Preparation of PVP: heat the purified water bath to 48°C, the volume ratio of N-vinylpyrrolidone and purified water is 0.33:1, the final concentration of azobisisobutyronitrile is 1.3%, and stir for 35 minutes;

[0055] (2) Preparation of povidone-iodine: the mass ratio of polyvinylpyrrolidone and iodine is 4.5:1; the mass ratio of iodine and potassium iodide is 1:2.8, heated to 75° C., and refluxed at constant temperature for 60...

Embodiment 3

[0057] Embodiment 3: A kind of povidone-iodine composition

[0058] The composition comprises in parts by weight: 10 parts of povidone-iodine and 63 parts of glycerin, that is, the mass ratio of glycerin and povidone-iodine is 0.4:1;

[0059] The weight average molecular weight of polyvinylpyrrolidone in described povidone iodine is 5 * 10 4 Da, the available iodine content is 9.86%, namely P7.

[0060] This composition was prepared according to the method described in Basic Example 1, with the difference from Basic Example 1 in that:

[0061] (1) Preparation of PVP: heat the absolute ethanol bath to 60°C, the volume ratio of N-vinylpyrrolidone and absolute ethanol is 0.7:1, the final concentration of azobisisobutyronitrile is 2%, and stir for 45 minutes;

[0062] (2) Preparation of povidone-iodine: the mass ratio of polyvinylpyrrolidone and iodine is 4.6:1; the mass ratio of iodine and potassium iodide is 1:3, heated to 78° C., and refluxed at constant temperature for 60 mi...

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Abstract

The invention relates to the technical field of medicines, in particular to a povidone iodine composition and a preparation method and external preparations thereof. The composition comprises the following components in parts by weight: 1-100 parts of povidone iodine and 1-100 parts of glycerol, wherein the weight-average molecular weight of the polyvinylpyrrolidone in the povidone iodine is (0.25-300)x10<4> Da, and the effective iodine content is 9.1-11.80%. The povidone iodine and the glycerol in the composition can generate synergistic antifungal effect and antitumor effect. The method optimizes the proportion of the povidone iodine and the glycerol, the weight-average molecular weight of the polyvinylpyrrolidone and the effective iodine content, obviously improves the synergistic effect of the povidone iodine and the glycerol, and enhances the inhibition effect and the antitumor effect on fungi. In addition, the composition has high stability, can be stored for a long time, and canbe widely used for preparing various types of external preparations.

Description

Technical field [0001] The invention relates to the field of medical technology, and in particular to a povidone-iodine composition and its preparation method and external preparation. Background technique [0002] Povidone-iodine (Polyvinyl pyrrolidone-Iodine, PVP-I), also known as iodophor, is the only iodine-containing disinfectant preparation included in the Chinese Pharmacopoeia. It has become an internationally recognized high-efficiency, broad-spectrum, non-toxic fungicide. It has extremely strong bactericidal power and a wide bactericidal spectrum. It has a strong and rapid killing effect on Gram-positive bacteria, Gram-negative bacteria, viruses, spores, fungi, protozoa, etc. It is commonly used in living organisms, animals, plants and Its environmental disinfection has important application value in medicine and daily chemicals. [0003] Povidone-iodine is formed by complexing iodine with the polymer polyvinylpyrrolidone (PVP) as a carrier. Polyvinylpyrrolidone is...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61P31/10A61P35/00A61K31/047
CPCA61K9/0014A61K31/047A61K33/18A61P31/10A61P35/00A61K2300/00
Inventor 向飞杜志博吴彦勍彭韪
Owner ZHONGSHAN WANHAN PHARM CO LTD
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