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A kind of preparation method of ceftazidime

A technology of ceftazime and ceftazime dihydrochloride, which is applied in the field of chemical pharmacy, can solve the problems of high impurity content and large crystals of ceftazime, and achieve the effects of low impurity content, simple preparation method and improved solubility

Active Publication Date: 2020-09-22
NORTH CHINA PHARMA HEBEI HUAMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method only adopts one crystallization, the crystal is larger, and the ceftazidime impurity content obtained is higher

Method used

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  • A kind of preparation method of ceftazidime
  • A kind of preparation method of ceftazidime
  • A kind of preparation method of ceftazidime

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preparation example Construction

[0026] A preparation method of ceftazime comprises the step of crystallizing ceftazime dihydrochloride as a raw material, and the crystallization is tertiary crystallization. The pH is adjusted to 2.8-2.9 during the first crystallization, the pH is adjusted to 3.4-3.6 during the second crystallization, and the pH is adjusted to 3.8-3.9 during the third crystallization.

[0027] The preparation method comprises the following steps:

[0028] A. Add ceftazidime dihydrochloride to purified water, stir at 0-10°C, add activated carbon or white clay, decolorize for 0.5-1 hour, filter to obtain ceftazime dihydrochloride decolorization solution;

[0029] The ratio of the volume of purified water in milliliters to the mass of ceftazidime dihydrochloride in grams is 5-6:1, and the amount of decolorizing agent added is 0.5-1% of the mass of ceftazidime dihydrochloride;

[0030] B. Add acetone or ethanol to the decolorization solution of ceftazidime dihydrochloride, add 3-5 mol / L sodium h...

Embodiment 1

[0036] A preparation method of ceftazime comprises the step of crystallizing ceftazime dihydrochloride as a raw material, and the crystallization is tertiary crystallization.

[0037] The preparation method comprises the following steps:

[0038] A. Add ceftazidime dihydrochloride to purified water, stir at 0°C, add activated carbon, decolorize for 0.5h, filter to obtain ceftazidime dihydrochloride decolorization solution;

[0039] The ratio of the volume milliliters of purified water to the mass grams of ceftazime dihydrochloride is 5:1, and the amount of decolorizer is 0.5% of the mass of ceftazidime dihydrochloride;

[0040] B. Add acetone to the ceftazime dihydrochloride decolorization solution, add 3mol / L sodium hydroxide solution to adjust the pH to 2.8, add 1‰ of ceftazime dihydrochloride seed crystals, and grow crystals at a temperature of 8°C , the crystal growth time is 2h;

[0041] The volume milliliters of acetone or ethanol and the mass gram ratio of ceftazidime...

Embodiment 2～4

[0046] Embodiments 2-4 have the same production process steps as in Embodiment 1, the difference is the selection of process parameters, as shown in Table 1 below.

[0047] Table 1

[0048]

[0049]

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PUM

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Abstract

The invention discloses a preparation method of ceftazime, which belongs to the field of chemical pharmacy, and comprises the steps of crystallizing ceftazime dihydrochloride as a raw material, and the crystallization is tertiary crystallization; the invention can reduce the use of acid solution and alkali solution, and the prepared ceftazime has The invention has the advantages of low impurity content, high stability and good solubility, simple preparation method, energy saving and environmental protection, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a method for preparing a compound, in particular to a method for preparing a β-lactam antibiotic, and belongs to the field of chemical pharmacy. Background technique [0002] Ceftazidime is a third-generation cephalosporin antibiotic, which has a strong effect on Gram-positive or negative bacteria. It is effective against Pseudomonas aeruginosa, E. Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus, hemolytic streptococcus, pneumococcus and bacillus aerogenes have strong antibacterial activity, especially for Pseudomonas aeruginosa, ceftazidime is the most effective antibiotic, its drug The injection is a sterile mixture of ceftazidime pentahydrate and sodium carbonate or arginine. The chemical name is (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxy Propan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0 ] Oct-2-ene-2-carboxylic acid pentahydr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/46C07D501/12
Inventor 田洪年贾全胡利敏张锁庆李庆伟石春利任峰刘树斌魏宝军贺娇
Owner NORTH CHINA PHARMA HEBEI HUAMIN PHARMA
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