Spray with geniposide and polyene phosphatidyl choline as active ingredients and preparation

A technology of polyene phosphatidylcholine and geniposide, which is applied in the field of sprays for respiratory diseases, can solve the problems of poor compliance of pediatric patients, patients' inability to adhere to medication, and affect the curative effect, so as to achieve convenient medication, shorten medication cycle, Effect with few side effects

Inactive Publication Date: 2019-05-28
HUNAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] If geniposide is used as an injection, there are some shortcomings in clinical application: the use of injections requires patients to go to the hospital for treatment, and the medication is inconvenient
These deficiencies make patients unable to adhere to the medication and affect the curative effect, especially the poor compliance of pediatric patients

Method used

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  • Spray with geniposide and polyene phosphatidyl choline as active ingredients and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of the inhalation spray of the pharmaceutical composition with geniposide and polyene phosphatidylcholine as active ingredients can be inhaled after nebulizing the formula liquid with an ultrasonic nebulizer and other instruments. The prescription for adult one-time nebulization is:

[0019] Geniposide powder 20mg

[0020] Polyene Phosphatidylcholine 250mg

[0021] Ethylparaben 30mg

[0022] Preparation method: Dissolve the original powder of geniposide, polyene phosphatidylcholine and ethylparaben in 100ml of normal saline, filter and pour the filtrate into a spray bottle for later use.

Embodiment 2

[0024] The preparation of the inhalation spray of the pharmaceutical composition with geniposide and polyene phosphatidylcholine as active ingredients can be inhaled after nebulizing the formula liquid with an ultrasonic nebulizer and other instruments. The prescription for adult one-time nebulization is:

[0025] Geniposide powder 20mg

[0026] Polyene Phosphatidylcholine 250mg

[0027] Potassium sorbate 5mg

[0028] Preparation method: Dissolve the original powder of geniposide, polyene phosphatidylcholine and potassium sorbate in 100ml of normal saline, filter and pour the filtrate into a spray bottle for later use.

Embodiment 3

[0030] The preparation of the inhalation spray of the pharmaceutical composition with geniposide and polyene phosphatidylcholine as active ingredients can be inhaled after nebulizing the formula liquid with an ultrasonic nebulizer and other instruments. The prescription for adult one-time nebulization is:

[0031] Geniposide powder 20mg

[0032] Polyene Phosphatidylcholine 250mg

[0033] Benzyl alcohol 45mg

[0034] Preparation method: Dissolve the original powder of geniposide, polyene phosphatidylcholine and benzyl alcohol in 100ml of normal saline, filter and pour the filtrate into a spray bottle for later use.

[0035] In order to better understand the present invention, the technical effects of the present invention will be illustrated through the following animal experiments.

[0036] Experimental animals: SPF grade healthy BALB / c female mice aged 6-8 weeks and weighing 20-24 g were selected. After feeding with non-egg protein for one week in a constant temperature, q...

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Abstract

The invention relates to a spray with geniposide and polyene phosphatidyl choline as active ingredients as well as a preparation technology and application of the spray. The spray is a pharmaceuticalcomposition which is prepared by selecting the geniposide and the polyene phosphatidyl choline as active pharmaceutical ingredients and mixing the active pharmaceutical ingredients with pharmaceutically acceptable auxiliary materials. The spray disclosed by the invention enables the geniposide and the polyene phosphatidyl choline to be directly distributed in nasal cavity, trachea, bronchia and lungs and can be used for treating respiratory system diseases such as asthma and bronchitis. The composition can synergistically and effectively play drug effects which are significantly better than those of single-dose geniposide or polyene phosphatidyl choline; the composition has the characteristics of enhancing treatment effects, shortening medication cycle and the like. The spray prepared anddeveloped by technical means disclosed by the invention has the advantages of fast onset, rapid effects, convenience in use and the like.

Description

technical field [0001] The invention belongs to the field of biotechnology, and specifically relates to a spray for treating respiratory diseases such as asthma and bronchitis and a preparation process thereof. host. Background technique [0002] Bronchial asthma (bronchial asthma), referred to as "asthma", is an allergic disease accompanied by immune dysfunction, and its incidence is on the rise. There are about 100 million asthma patients in the world. The pathogenesis of asthma is complicated, and it is a chronic airway inflammatory disease involving a variety of inflammatory cells and their cell components in the airway. Airway hyperresponsiveness and airway inflammation are important pathological features. At present, clinical control is mainly achieved through long-term inhalation of glucocorticoids. There is no effective cure for bronchial asthma, and it has become a major chronic disease that seriously threatens public health. The disease can occur at any age, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/7048A61K31/685A61P11/06A61P11/00A61P31/00
Inventor 胡翔黄淑兰周旻昱陈晓雨钟贝芬李志伟
Owner HUNAN NORMAL UNIVERSITY
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